Interaction between mitochondria and microbiota modulating cellular metabolism in inflammatory bowel disease.
Bacterial metabolites
Cellular metabolism
Inflammatory bowel disease (IBD)
Mitochondria-microbiota interaction
Mitochondrial DNA (mtDNA) polymorphisms
Mitochondrial reactive oxygen species (ROS)
Journal
Journal of molecular medicine (Berlin, Germany)
ISSN: 1432-1440
Titre abrégé: J Mol Med (Berl)
Pays: Germany
ID NLM: 9504370
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
received:
24
07
2023
accepted:
25
09
2023
revised:
06
09
2023
medline:
6
12
2023
pubmed:
11
10
2023
entrez:
11
10
2023
Statut:
ppublish
Résumé
Inflammatory bowel disease (IBD) is a prototypic complex disease in the gastrointestinal tract that has been increasing in incidence and prevalence in recent decades. Although the precise pathophysiology of IBD remains to be elucidated, a large body of evidence suggests the critical roles of mitochondria and intestinal microbiota in the pathogenesis of IBD. In addition to their contributions to the disease, both mitochondria and gut microbes may interact with each other and modulate disease-causing cell activities. Therefore, we hypothesize that dissecting this unique interaction may help to identify novel pathways involved in IBD, which will further contribute to discovering new therapeutic approaches to the disease. As poorly treated IBD significantly affects the quality of life of patients and is associated with risks and complications, successful treatment is crucial. In this review, we stratify previously reported experimental and clinical observations of the role of mitochondria and intestinal microbiota in IBD. Additionally, we review the intercommunication between mitochondria, and the intestinal microbiome in patients with IBD is reviewed along with the potential mediators for these interactions. We specifically focus on their roles in cellular metabolism in intestinal epithelial cells and immune cells. To this end, we propose a potential therapeutic intervention strategy for IBD.
Identifiants
pubmed: 37819377
doi: 10.1007/s00109-023-02381-w
pii: 10.1007/s00109-023-02381-w
pmc: PMC10698103
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1513-1526Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : 454193335
Informations de copyright
© 2023. The Author(s).
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