The importance of polymorphisms in the genes encoding glutathione S-transferase isoenzymes in development of selected cancers and cardiovascular diseases.
Breast cancer
Cardiovascular disease
Colorectal cancer
Glutathione S-transferase
Polymorphism
Prostate cancer
Journal
Molecular biology reports
ISSN: 1573-4978
Titre abrégé: Mol Biol Rep
Pays: Netherlands
ID NLM: 0403234
Informations de publication
Date de publication:
Nov 2023
Nov 2023
Historique:
received:
04
01
2023
accepted:
04
10
2023
medline:
10
11
2023
pubmed:
11
10
2023
entrez:
11
10
2023
Statut:
ppublish
Résumé
Glutathione S-transferases are a family of enzymes, whose main role is to detoxify cells from many exogenous factors, such as xenobiotics or carcinogens. It has also been proven that changes in the genes encoding these enzymes may affect the incidence of selected cancers and cardiovascular diseases. The aim of this study was to review the most important reports related to the role of glutathione S-transferases in the pathophysiology of two of the most common diseases in modern society - cancers and cardiovascular diseases. It was shown that polymorphisms in the genes encoding glutathione S-transferases are associated with the development of these diseases. However, depending on the ethnic group, the researchers obtained divergent results related to this field. In the case of the GSTP1 A/G gene polymorphism was shown an increased incidence of breast cancer in Asian women, while this relationship in European and African women was not found. Similarly. In the case of cardiovascular diseases, the differences in the influence of GSTM1, GSTT1, GSTP1 and GSTA1 polymorphisms on their development or lack of it depending on the continent were shown. These examples show that the development of the above-mentioned diseases is not only influenced by genetic changes, but their pathophysiology is more complex. The mere presence of a specific genotype within a studied polymorphism may not predispose to cancer, but in combination with environmental factors, which often depend on the place of residence, it may elevate the chance of developing the selected disease.
Identifiants
pubmed: 37819495
doi: 10.1007/s11033-023-08894-4
pii: 10.1007/s11033-023-08894-4
pmc: PMC10635984
doi:
Substances chimiques
Isoenzymes
0
Glutathione Transferase
EC 2.5.1.18
Glutathione S-Transferase pi
EC 2.5.1.18
Glutathione
GAN16C9B8O
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
9649-9661Informations de copyright
© 2023. The Author(s).
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