Good practices for the automated production of
Automation
Fluorine-18
Positron emission tomography (PET)
Silicon fluoride acceptor
Journal
EJNMMI radiopharmacy and chemistry
ISSN: 2365-421X
Titre abrégé: EJNMMI Radiopharm Chem
Pays: England
ID NLM: 101714628
Informations de publication
Date de publication:
11 Oct 2023
11 Oct 2023
Historique:
received:
28
07
2023
accepted:
03
10
2023
medline:
11
10
2023
pubmed:
11
10
2023
entrez:
11
10
2023
Statut:
epublish
Résumé
The positron emitting isotope fluorine-18 ( A radiotracer's clinical success primarily hinges on whether its synthesis can be automated. Due to its simplicity, the SiFA chemistry, which is based on isotopic exchange ( This current review highlights the most recent achievements in SiFA radiopharmaceutical automation geared towards large batch production for clinical application. Best practice advice and guidance towards a facilitated implementation of the SiFA technology into new and already operating PET tracer production facilities is provided. A brief outlook spotlights the future potential of SiFA radiochemistry within the landscape of non-canonical labeling chemistries.
Sections du résumé
BACKGROUND
BACKGROUND
The positron emitting isotope fluorine-18 (
MAIN BODY
METHODS
A radiotracer's clinical success primarily hinges on whether its synthesis can be automated. Due to its simplicity, the SiFA chemistry, which is based on isotopic exchange (
CONCLUSION
CONCLUSIONS
This current review highlights the most recent achievements in SiFA radiopharmaceutical automation geared towards large batch production for clinical application. Best practice advice and guidance towards a facilitated implementation of the SiFA technology into new and already operating PET tracer production facilities is provided. A brief outlook spotlights the future potential of SiFA radiochemistry within the landscape of non-canonical labeling chemistries.
Identifiants
pubmed: 37819534
doi: 10.1186/s41181-023-00215-1
pii: 10.1186/s41181-023-00215-1
pmc: PMC10567618
doi:
Types de publication
Journal Article
Langues
eng
Pagination
25Informations de copyright
© 2023. Springer Nature Switzerland AG.
Références
Nat Protoc. 2020 Dec;15(12):3827-3843
pubmed: 33230332
J Labelled Comp Radiopharm. 2018 Mar;61(3):126-140
pubmed: 29110328
EJNMMI Radiopharm Chem. 2022 Oct 22;7(1):27
pubmed: 36271969
J Pharm Biomed Anal. 2015;111:209-14
pubmed: 25898315
Eur J Nucl Med Mol Imaging. 2023 Sep;50(11):3390-3399
pubmed: 37358620
Angew Chem Int Ed Engl. 2018 May 28;57(22):6658-6661
pubmed: 29659110
EJNMMI Radiopharm Chem. 2021 Aug 26;6(1):30
pubmed: 34436693
Clin Nucl Med. 2021 Aug 1;46(8):667-668
pubmed: 33782306
Pharm Res. 2018 May 24;35(8):148
pubmed: 29797101
Front Oncol. 2023 Jan 30;13:992316
pubmed: 36793617
Pharmaceuticals (Basel). 2021 Jul 20;14(7):
pubmed: 34358127
Eur J Nucl Med Mol Imaging. 2021 Oct;48(11):3571-3581
pubmed: 33928401
Nucl Med Biol. 2020 Sep-Oct;88-89:86-95
pubmed: 32828007
Eur J Nucl Med Mol Imaging. 2020 Apr;47(4):870-880
pubmed: 31492994
Bioconjug Chem. 2016 Feb 17;27(2):267-79
pubmed: 26566577
Diagnostics (Basel). 2021 Oct 03;11(10):
pubmed: 34679525
Eur J Nucl Med Mol Imaging. 2019 Oct;46(11):2400-2401
pubmed: 31352578
Semin Nucl Med. 2017 Sep;47(5):493-523
pubmed: 28826523
EJNMMI Radiopharm Chem. 2021 Jan 23;6(1):4
pubmed: 33484364
J Am Chem Soc. 2021 Mar 17;143(10):3753-3763
pubmed: 33630577
Nuklearmedizin. 2012;51(1):1-8
pubmed: 21989864