Anticancer effects of gossypetin from Hibiscus sabdariffa in oral squamous cell carcinoma.
Journal
Journal of applied oral science : revista FOB
ISSN: 1678-7765
Titre abrégé: J Appl Oral Sci
Pays: Brazil
ID NLM: 101189774
Informations de publication
Date de publication:
2023
2023
Historique:
received:
10
07
2023
accepted:
21
08
2023
medline:
2
11
2023
pubmed:
11
10
2023
entrez:
11
10
2023
Statut:
epublish
Résumé
Gossypetin, isolated from Hibiscus sabdariffa L, has been shown to have various pharmacological effects including anti-inflammatory and antibacterial activity against various diseases. However, since the effect of gossypetin in oral cancer remains to be reported, we aimed to investigate the anticancer activity and mechanisms of gossypetin in oral squamous cell carcinoma (OSCC). The proliferation of OSCC cells was evaluated by cell viability and soft agar colony assays. The effects of gossypetin on the migration and invasion of OSCC cells was investigated by wound healing and transwell invasion assays, respectively. Apoptosis and cell cycle arrest were measured by flow cytometry. Moreover, the anticancer mechanism of gossypetin in OSCC cells was analyzed by western blotting. Gossypetin inhibited the proliferation, migration, and invasion of OSCC cells and induced apoptosis by upregulating the Bax/Bcl-2 ratio and cell cycle arrest at the G2/M phase. Furthermore, gossypetin regulated the activation of extracellular signal-regulated kinase and nuclear factor-kappa B. Results showed that gossypetin inhibits the proliferation, migration, and invasion of OSCC cells and triggers apoptosis and cell cycle arrest in OSCC. Therefore, gossypetin has the potential for use as a chemopreventive agent in oral cancer.
Identifiants
pubmed: 37820185
pii: S1678-77572023000100448
doi: 10.1590/1678-7757-2023-0243
pmc: PMC10561964
pii:
doi:
Substances chimiques
gossypetin
SET4M23ZTM
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e20230243Références
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