Cross-sectional and longitudinal associations of dichlorodiphenyltrichloroethane (DDT) metabolites exposure with lung function alternation in the Chinese general adults.
DDE
DDT
General population
Lung function
Organochlorine
Journal
The Science of the total environment
ISSN: 1879-1026
Titre abrégé: Sci Total Environ
Pays: Netherlands
ID NLM: 0330500
Informations de publication
Date de publication:
20 Dec 2023
20 Dec 2023
Historique:
received:
06
09
2023
revised:
07
10
2023
accepted:
08
10
2023
medline:
15
11
2023
pubmed:
12
10
2023
entrez:
11
10
2023
Statut:
ppublish
Résumé
Exposure of dichlorodiphenyltrichloroethane (DDT) pesticide was suggested to be associated with adverse effects on the respiratory system. However, the effects of DDT exposure on lung function remain unclear. Our objectives were to investigate the potential associations of internal levels of DDT and its metabolites including dichlorodiphenyldichloroethylene (DDE) and dichlorodiphenyldichloroethane (DDD) with lung function. Serum DDT, DDE, and DDD concentrations and lung function were measured among 3968 general adults from the Wuhan-Zhuhai cohort. The cross-sectional and longitudinal associations of serum DDT and its metabolites with lung function were assessed using linear mixed models. The results showed negative dose-response relationships of serum DDT, DDE, and DDD levels with forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV
Identifiants
pubmed: 37820796
pii: S0048-9697(23)06356-8
doi: 10.1016/j.scitotenv.2023.167729
pii:
doi:
Substances chimiques
o,p'-DDT
D4K93Z1TBH
DDT
CIW5S16655
Dichlorodiphenyl Dichloroethylene
4M7FS82U08
2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene
DM084YLQ1L
Hydrocarbons, Chlorinated
0
Pesticides
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
167729Informations de copyright
Copyright © 2023 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.