Cancer Detection Rate and Abnormal Interpretation Rate of Prostate MRI Performed for Clinical Suspicion of Prostate Cancer.

To report cancer detection rate (CDR) and abnormal interpretation rate (AIR) in prostate MRI performed for clinical suspicion of prostate cancer (PCa). This retrospective single-institution, three-center study included patients who underwent MRI for clinical suspicion of PCa between 2017-2021. Patients with known PCa were excluded. Patient-level PI-RADS score was extracted from the radiology report. AIR was defined as number of abnormal MRI (PI-RADS score 3-5) / total number of MRI. CDR was defined as number of clinically significant PCa (csPCa: Gleason score ≥7) detected at abnormal MRI / total number of MRI. AIR, CDR, and CDR adjusted for pathology confirmation rate (aCDR) were calculated for each of 3 centers and pre-MRI biopsy status (biopsy naïve and previous negative biopsy). A total of 9686 exams (8643 unique patients) were included. AIR, CDR, and aCDR were 45.4%, 23.8%, and 27.6% for Center I; 47.2%, 20.0%, and 22.8% for Center II; and 42.3%, 27.2%, and 30.1% for Center III, respectively. Pathology confirmation rate ranged from 81.6-88.0% across three centers. AIR and CDR for biopsy naïve patients were 45.5-52.6% and 24.2-33.5% across three centers, respectively, while those for previous negative biopsy were 27.2-39.8% and 11.7-14.2% across three centers, respectively. We reported CDR and AIR in prostate MRI for clinical suspicion of PCa. CDR needs to be adjusted for pathology confirmation rate and pre-MRI biopsy status for inter-facility comparison.

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