Phosphatidylinositol 3,5-bisphosphate facilitates axonal vesicle transport and presynapse assembly.
Journal
Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511
Informations de publication
Date de publication:
13 10 2023
13 10 2023
Historique:
medline:
1
11
2023
pubmed:
12
10
2023
entrez:
12
10
2023
Statut:
ppublish
Résumé
Neurons relay information via specialized presynaptic compartments for neurotransmission. Unlike conventional organelles, the specialized apparatus characterizing the neuronal presynapse must form de novo. How the components for presynaptic neurotransmission are transported and assembled is poorly understood. Our results show that the rare late endosomal signaling lipid phosphatidylinositol 3,5-bisphosphate [PI(3,5)P
Identifiants
pubmed: 37824668
doi: 10.1126/science.adg1075
doi:
Substances chimiques
KIF1A protein, human
0
Kinesins
EC 3.6.4.4
phosphatidylinositol 3,5-diphosphate
0
Phosphatidylinositol Phosphates
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM