Iron(II)-cyclopentadienyl compounds are cytotoxic against colon adenocarcinoma cell lines: Ethylenebis(diphenylphosphane) vs. triphenylphosphane.

Humans Iron Colonic Neoplasms / drug therapy Cell Line, Tumor Adenocarcinoma Hydrogen Peroxide Antineoplastic Agents / pharmacology Ferrous Compounds / pharmacology
ABCB1 Anticancer Colon adenocarcinoma Iron(II)-cyclopentadienyl Metallodrugs Redox activity

Journal

Journal of inorganic biochemistry
ISSN: 1873-3344
Titre abrégé: J Inorg Biochem
Pays: United States
ID NLM: 7905788

Informations de publication

Date de publication:
12 2023
Historique:
received: 10 08 2023
revised: 13 09 2023
accepted: 23 09 2023
medline: 30 10 2023
pubmed: 13 10 2023
entrez: 12 10 2023
Statut: ppublish

Résumé

Structure-activity studies aiming to understand the role of each coligand in the formulation of new metallodrugs is an important subject. In that frame, six new compounds with general formula [Fe(η

Identifiants

DOI: 10.1016/j.jinorgbio.2023.112386 PMID: 37827090
pubmed: 37827090
pii: S0162-0134(23)00268-4
doi: 10.1016/j.jinorgbio.2023.112386
pii:
doi:

Substances chimiques

tesmilifene I43T3ID6G2
Iron E1UOL152H7
Hydrogen Peroxide BBX060AN9V
Antineoplastic Agents 0
Ferrous Compounds 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

112386

Informations de copyright

Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Adhan Pilon (A)

Centro de Química Estrutural, Institute of Molecular Sciences and Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade de Lisboa, Campo Grande, 1749-016 Lisboa, Portugal.

Fernando Avecilla (F)

Universidade da Coruña, Grupo NanoToxGen, Centro Interdisciplinar de Química y Biología (CICA), Departamento de Química, Facultade de Ciencias, Campus de A Coruña, 15071 A Coruña, Spain.

Bálint Rácz (B)

Department of Medical Microbiology, Albert Szent-Györgyi Medical School, University of Szeged, Semmelweis utca 6, H-6725 Szeged, Hungary.

Gerda T Gátszegi (GT)

Department of Medical Microbiology, Albert Szent-Györgyi Medical School, University of Szeged, Semmelweis utca 6, H-6725 Szeged, Hungary; MTA-SZTE Lendület Functional Metal Complexes Research Group, Department of Inorganic and Analytical Chemistry, University of Szeged, Dóm tér 7, H-6720 Szeged, Hungary.

Gabriella Spengler (G)

Department of Medical Microbiology, Albert Szent-Györgyi Medical School, University of Szeged, Semmelweis utca 6, H-6725 Szeged, Hungary.

M Paula Robalo (MP)

Centro de Química Estrutural, Institute of Molecular Sciences, Av. Rovisco Pais, 1049-001 Lisboa, Portugal; Departamento de Engenharia Química, Instituto Superior de Engenharia de Lisboa, Instituto Politécnico de Lisboa, Av. Conselheiro Emídio Navarro, 1, 1959-007 Lisboa, Portugal.

Éva A Enyedy (ÉA)

MTA-SZTE Lendület Functional Metal Complexes Research Group, Department of Inorganic and Analytical Chemistry, University of Szeged, Dóm tér 7, H-6720 Szeged, Hungary.

M Helena Garcia (MH)

Centro de Química Estrutural, Institute of Molecular Sciences and Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade de Lisboa, Campo Grande, 1749-016 Lisboa, Portugal.

Andreia Valente (A)

Centro de Química Estrutural, Institute of Molecular Sciences and Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade de Lisboa, Campo Grande, 1749-016 Lisboa, Portugal. Electronic address: amvalente@fc.ul.pt.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Iron(II)-cyclopentadienyl compounds are...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Fer › Iron(II)-cyclopentadienyl compounds are...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Tumeurs de l'intestin › Tumeurs du côlon › Iron(II)-cyclopentadienyl compounds are...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Iron(II)-cyclopentadienyl compounds are...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs épithéliales épidermoïdes et glandulaires › Carcinomes › Adénocarcinome › Iron(II)-cyclopentadienyl compounds are...
questionsmedicales.fr › Composés chimiques organiques › Radicaux libres › Peroxydes › Peroxyde d'hydrogène › Iron(II)-cyclopentadienyl compounds are...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Iron(II)-cyclopentadienyl compounds are...
questionsmedicales.fr › Produits chimiques inorganiques › Composés du fer › Composés du fer II › Iron(II)-cyclopentadienyl compounds are...