Adipocyte lipolysis protects mice against Trypanosoma brucei infection.
Journal
Nature microbiology
ISSN: 2058-5276
Titre abrégé: Nat Microbiol
Pays: England
ID NLM: 101674869
Informations de publication
Date de publication:
Nov 2023
Nov 2023
Historique:
received:
26
12
2022
accepted:
11
09
2023
medline:
8
11
2023
pubmed:
13
10
2023
entrez:
12
10
2023
Statut:
ppublish
Résumé
Trypanosoma brucei causes African trypanosomiasis, colonizing adipose tissue and inducing weight loss. Here we investigated the molecular mechanisms responsible for adipose mass loss and its impact on disease pathology. We found that lipolysis is activated early in infection. Mice lacking B and T lymphocytes fail to upregulate adipocyte lipolysis, resulting in higher fat mass retention. Genetic ablation of the rate-limiting adipose triglyceride lipase specifically from adipocytes (Adipoq
Identifiants
pubmed: 37828246
doi: 10.1038/s41564-023-01496-7
pii: 10.1038/s41564-023-01496-7
pmc: PMC10627827
doi:
Substances chimiques
Lipase
EC 3.1.1.3
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2020-2032Subventions
Organisme : EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council)
ID : 771714
Organisme : Louis-Jeantet Foundation (Fondation Louis-Jeantet)
ID : Louis Jeantet Prize 2015
Informations de copyright
© 2023. The Author(s).
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