Engrailed: Pathological and physiological effects of a multifunctional developmental gene.
Engrailed-1
embryonic development
midbrain dopaminergic
overall survival
overexpression
Journal
Genesis (New York, N.Y. : 2000)
ISSN: 1526-968X
Titre abrégé: Genesis
Pays: United States
ID NLM: 100931242
Informations de publication
Date de publication:
13 Oct 2023
13 Oct 2023
Historique:
revised:
14
09
2023
received:
23
06
2023
accepted:
14
09
2023
medline:
13
10
2023
pubmed:
13
10
2023
entrez:
13
10
2023
Statut:
aheadofprint
Résumé
Engrailed-1 (EN1) is a developmental gene that encodes En1, a highly conserved transcription factor involved in regionalization during early embryogenesis and in the later maintenance of normal neurons. After birth, EN1 still plays a role in the development and physiology of the body; for example, it exerts a protective effect on midbrain dopaminergic (mDA) neurons, and loss of EN1 causes mDA neurons in the ventral midbrain to gradually die approximately 6 weeks after birth, resulting in motor and nonmotor symptoms similar to those observed in Parkinson's disease. Notably, EN1 has been identified as a possible susceptibility gene for idiopathic Parkinson's disease in humans. EN1 is involved in the processes of wound-healing scar production and tissue and organ fibrosis. Additionally, EN1 can lead to tumorigenesis and thus provides a target for the treatment of some tumors. In this review, we summarize the effects of EN1 on embryonic organ development, describe the consequences of the deletion or overexpression of the EN1 gene, and discuss the pathways in which EN1 is involved. We hope to clarify the role of EN1 as a developmental gene and present potential therapeutic targets for diseases involving the EN1 gene.
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e23557Subventions
Organisme : International Cooperation Fund for Projects of Science and Technology Development Plan of Jilin Province
ID : 20220402065G H
Informations de copyright
© 2023 Wiley Periodicals LLC.
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