The function of astrocytes and their role in neurological diseases.
astrocyte
drug treatment
function
neurological disorders
structure
Journal
The European journal of neuroscience
ISSN: 1460-9568
Titre abrégé: Eur J Neurosci
Pays: France
ID NLM: 8918110
Informations de publication
Date de publication:
11 2023
11 2023
Historique:
revised:
11
09
2023
received:
30
05
2023
accepted:
13
09
2023
medline:
8
11
2023
pubmed:
13
10
2023
entrez:
13
10
2023
Statut:
ppublish
Résumé
Astrocytes have countless links with neurons. Previously, astrocytes were only considered a scaffold of neurons; in fact, astrocytes perform a variety of functions, including providing support for neuronal structures and energy metabolism, offering isolation and protection and influencing the formation, function and elimination of synapses. Because of these functions, astrocytes play an critical role in central nervous system (CNS) diseases. The regulation of the secretiory factors, receptors, channels and pathways of astrocytes can effectively inhibit the occurrence and development of CNS diseases, such as neuromyelitis optica (NMO), multiple sclerosis, Alzheimer's disease (AD), Parkinson's disease (PD) and Huntington's disease. The expression of aquaporin 4 in AS is directly related to NMO and indirectly involved in the clearance of Aβ and tau proteins in AD. Connexin 43 has a bidirectional effect on glutamate diffusion at different stages of stroke. Interestingly, astrocytes reduce the occurrence of PD through multiple effects such as secretion of related factors, mitochondrial autophagy and aquaporin 4. Therefore, this review is focused on the structure and function of astrocytes and the correlation between astrocytes and CNS diseases and drug treatment to explore the new functions of astrocytes with the astrocytes as the target. This, in turn, would provide a reference for the development of new drugs to protect neurons and promote the recovery of nerve function.
Substances chimiques
Aquaporin 4
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3932-3961Informations de copyright
© 2023 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.
Références
Abbott, N. J., Rönnbäck, L., & Hansson, E. (2006). Astrocyte-endothelial interactions at the blood-brain barrier. Nature Reviews. Neuroscience, 7, 41-53.
Abdelfattah, M. S., Badr, S. E. A., Lotfy, S. A., Attia, G. H., Aref, A. M., Abdel Moneim, A. E., & Kassab, R. B. (2020). Rutin and selenium co-administration reverse 3-nitropropionic acid-induced neurochemical and molecular impairments in a mouse model of Huntington's disease. Neurotoxicity Research, 37, 77-92.
Aizawa, H., Sun, W., Sugiyama, K., Itou, Y., Aida, T., Cui, W., Toyoda, S., Terai, H., Yanagisawa, M., & Tanaka, K. (2020). Glial glutamate transporter GLT-1 determines susceptibility to spreading depression in the mouse cerebral cortex. Glia, 68, 2631-2642.
Allen, N. J., Bennett, M. L., Foo, L. C., Wang, G. X., Chakraborty, C., Smith, S. J., & Barres, B. A. (2012). Astrocyte glypicans 4 and 6 promote formation of excitatory synapses via GluA1 AMPA receptors. Nature, 486, 410-414.
Allen, N. J., & Eroglu, C. (2017). Cell biology of astrocyte-synapse interactions. Neuron, 96, 697-708.
Alvarez, J. I., Dodelet-Devillers, A., Kebir, H., Ifergan, I., Fabre, P. J., Terouz, S., Sabbagh, M., Wosik, K., Bourbonnière, L., Bernard, M., van Horssen, J., de Vries, H. E., Charron, F., & Prat, A. (2011). The hedgehog pathway promotes blood-brain barrier integrity and CNS immune quiescence. Science, 334, 1727-1731.
Araque, A., Sanzgiri, R. P., Parpura, V., & Haydon, P. G. (1999). Astrocyte-induced modulation of synaptic transmission. Canadian Journal of Physiology and Pharmacology, 77, 699-706.
Asanuma, M., & Miyazaki, I. (2021). Anti-oxidants in astrocytes as target of neuroprotection for Parkinson's disease. Nihon Yakurigaku Zasshi, 156, 14-20.
Asavapanumas, N., Ratelade, J., & Verkman, A. S. (2014). Unique neuromyelitis optica pathology produced in naïve rats by intracerebral administration of NMO-IgG. Acta Neuropathologica, 127, 539-551.
Ates, G., Goldberg, J., Currais, A., & Maher, P. (2020). CMS121, a fatty acid synthase inhibitor, protects against excess lipid peroxidation and inflammation and alleviates cognitive loss in a transgenic mouse model of Alzheimer's disease. Redox Biology, 36, 101648.
Atochin, D. N., & Huang, P. L. (2011). Role of endothelial nitric oxide in cerebrovascular regulation. Current Pharmaceutical Biotechnology, 12, 1334-1342.
Balashov, K. E., Aung, L. L., Vaknin-Dembinsky, A., Dhib-Jalbut, S., & Weiner, H. L. (2010). Interferon-β inhibits toll-like receptor 9 processing in multiple sclerosis. Annals of Neurology, 68, 899-906.
Barker, A. J., Koch, S. M., Reed, J., Barres, B. A., & Ullian, E. M. (2008). Developmental control of synaptic receptivity. The Journal of Neuroscience, 28, 8150-8160.
Batiuk, M. Y., Martirosyan, A., Wahis, J., de Vin, F., Marneffe, C., Kusserow, C., Koeppen, J., Viana, J. F., Oliveira, J. F., Voet, T., Ponting, C. P., Belgard, T. G., & Holt, M. G. (2020). Identification of region-specific astrocyte subtypes at single cell resolution. Nature Communications, 11, 1220.
Beard, E., Lengacher, S., Dias, S., Magistretti, P. J., & Finsterwald, C. (2021). Astrocytes as key regulators of brain energy metabolism: New therapeutic perspectives. Frontiers in Physiology, 12, 825816.
Bekele Feyissa, Y., Chiodi, F., Sui, Y., & Berzofsky, J. A. (2021). The role of CXCL13 in antibody responses to HIV-1 infection and vaccination. Frontiers in Immunology, 12, 638872.
Bélanger, M., Allaman, I., & Magistretti, P. J. (2011). Brain energy metabolism: Focus on astrocyte-neuron metabolic cooperation. Cell Metabolism, 14, 724-738.
Bellesi, M., de Vivo, L., Chini, M., Gilli, F., Tononi, G., & Cirelli, C. (2017). Sleep loss promotes astrocytic phagocytosis and microglial activation in mouse cerebral cortex. The Journal of Neuroscience, 37, 5263-5273.
Bhargava, P., Smith, M. D., Mische, L., Harrington, E., Fitzgerald, K. C., Martin, K., Kim, S., Reyes, A. A., Gonzalez-Cardona, J., Volsko, C., Tripathi, A., Singh, S., Varanasi, K., Lord, H. N., Meyers, K., Taylor, M., Gharagozloo, M., Sotirchos, E. S., Nourbakhsh, B., … Calabresi, P. A. (2020). Bile acid metabolism is altered in multiple sclerosis and supplementation ameliorates neuroinflammation. The Journal of Clinical Investigation, 130, 3467-3482.
Bialas, A. R., & Stevens, B. (2013). TGF-β signaling regulates neuronal C1q expression and developmental synaptic refinement. Nature Neuroscience, 16, 1773-1782.
Blanco-Suárez, E., Caldwell, A. L., & Allen, N. J. (2017). Role of astrocyte-synapse interactions in CNS disorders. The Journal of Physiology, 595, 1903-1916.
Bolaños, J. P. (2016). Bioenergetics and redox adaptations of astrocytes to neuronal activity. Journal of Neurochemistry, 139(Suppl 2), 115-125.
Bozic, I., Savic, D., & Lavrnja, I. (2021). Astrocyte phenotypes: Emphasis on potential markers in neuroinflammation. Histology and Histopathology, 36, 267-290.
Bozoyan, L., Khlghatyan, J., & Saghatelyan, A. (2012). Astrocytes control the development of the migration-promoting vasculature scaffold in the postnatal brain via VEGF signaling. The Journal of Neuroscience, 32, 1687-1704.
Brill, J., & Huguenard, J. R. (2008). Sequential changes in AMPA receptor targeting in the developing neocortical excitatory circuit. The Journal of Neuroscience, 28, 13918-13928.
Brooks, G. A. (2023). What the lactate shuttle means for sports nutrition. Nutrients, 15, 2178.
Burmistrova, O., Olias-Arjona, A., Lapresa, R., Jimenez-Blasco, D., Eremeeva, T., Shishov, D., Romanov, S., Zakurdaeva, K., Almeida, A., Fedichev, P. O., & Bolaños, J. P. (2019). Targeting PFKFB3 alleviates cerebral ischemia-reperfusion injury in mice. Scientific Reports, 9, 11670.
Bush, T. G., Puvanachandra, N., Horner, C. H., Polito, A., Ostenfeld, T., Svendsen, C. N., Mucke, L., Johnson, M. H., & Sofroniew, M. V. (1999). Leukocyte infiltration, neuronal degeneration, and neurite outgrowth after ablation of scar-forming, reactive astrocytes in adult transgenic mice. Neuron, 23, 297-308.
Cahoy, J. D., Emery, B., Kaushal, A., Foo, L. C., Zamanian, J. L., Christopherson, K. S., Xing, Y., Lubischer, J. L., Krieg, P. A., Krupenko, S. A., Thompson, W. J., & Barres, B. A. (2008). A transcriptome database for astrocytes, neurons, and oligodendrocytes: A new resource for understanding brain development and function. The Journal of Neuroscience, 28, 264-278.
Carnero Contentti, E., & Correale, J. (2021). Neuromyelitis optica spectrum disorders: From pathophysiology to therapeutic strategies. Journal of Neuroinflammation, 18, 208.
Cerri, S., Mus, L., & Blandini, F. (2019). Parkinson's disease in women and men: What's the difference? Journal of Parkinson's Disease, 9, 501-515.
Charabati, M., Wheeler, M. A., Weiner, H. L., & Quintana, F. J. (2023). Multiple sclerosis: Neuroimmune crosstalk and therapeutic targeting. Cell, 186, 1309-1327.
Chen, L. W., Horng, L. Y., Wu, C. L., Sung, H. C., & Wu, R. T. (2012). Activating mitochondrial regulator PGC-1α expression by astrocytic NGF is a therapeutic strategy for Huntington's disease. Neuropharmacology, 63, 719-732.
Chen, Z., Yuan, Z., Yang, S., Zhu, Y., Xue, M., Zhang, J., & Leng, L. (2023). Brain energy metabolism: Astrocytes in neurodegenerative diseases. CNS Neuroscience & Therapeutics, 29, 24-36.
Chever, O., Pannasch, U., Ezan, P., & Rouach, N. (2014). Astroglial connexin 43 sustains glutamatergic synaptic efficacy. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 369, 20130596.
Choi, H. J., Park, J. H., Jeong, Y. J., Hwang, J. W., Lee, S., Lee, H., Seol, E., Kim, I. W., Cha, B. Y., Seo, J., Moon, M., & Hoe, H. S. (2022). Donepezil ameliorates Aβ pathology but not tau pathology in 5xFAD mice. Molecular Brain, 15, 63.
Christopherson, K. S., Ullian, E. M., Stokes, C. C., Mullowney, C. E., Hell, J. W., Agah, A., Lawler, J., Mosher, D. F., Bornstein, P., & Barres, B. A. (2005). Thrombospondins are astrocyte-secreted proteins that promote CNS synaptogenesis. Cell, 120, 421-433.
Chung, W. S., Clarke, L. E., Wang, G. X., Stafford, B. K., Sher, A., Chakraborty, C., Joung, J., Foo, L. C., Thompson, A., Chen, C., Smith, S. J., & Barres, B. A. (2013). Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways. Nature, 504, 394-400.
Cohen-Salmon, M., Slaoui, L., Mazaré, N., Gilbert, A., Oudart, M., Alvear-Perez, R., Elorza-Vidal, X., Chever, O., & Boulay, A. C. (2021). Astrocytes in the regulation of cerebrovascular functions. Glia, 69, 817-841.
Colombo, E., Bassani, C., de Angelis, A., Ruffini, F., Ottoboni, L., Comi, G., Martino, G., & Farina, C. (2020). Siponimod (BAF312) activates Nrf2 while hampering NFκB in human astrocytes, and protects from astrocyte-induced neurodegeneration. Frontiers in Immunology, 11, 635.
Colombo, E., Di Dario, M., Capitolo, E., Chaabane, L., Newcombe, J., Martino, G., & Farina, C. (2014). Fingolimod may support neuroprotection via blockade of astrocyte nitric oxide. Annals of Neurology, 76, 325-337.
Constantinescu, C. S., Tani, M., Ransohoff, R. M., Wysocka, M., Hilliard, B., Fujioka, T., Murphy, S., Tighe, P. J., Das Sarma, J., Trinchieri, G., & Rostami, A. (2005). Astrocytes as antigen-presenting cells: Expression of IL-12/IL-23. Journal of Neurochemistry, 95, 331-340.
Daneman, R., & Prat, A. (2015). The blood-brain barrier. Cold Spring Harbor Perspectives in Biology, 7, a020412.
Davies, S. J., Fitch, M. T., Memberg, S. P., Hall, A. K., Raisman, G., & Silver, J. (1997). Regeneration of adult axons in white matter tracts of the central nervous system. Nature, 390, 680-683.
Dohgu, S., Yamauchi, A., Takata, F., Naito, M., Tsuruo, T., Higuchi, S., Sawada, Y., & Kataoka, Y. (2004). Transforming growth factor-beta1 upregulates the tight junction and P-glycoprotein of brain microvascular endothelial cells. Cellular and Molecular Neurobiology, 24, 491-497.
Dong, R., Han, Y., Jiang, L., Liu, S., Zhang, F., Peng, L., Wang, Z., Ma, Z., Xia, T., & Gu, X. (2022). Connexin 43 gap junction-mediated astrocytic network reconstruction attenuates isoflurane-induced cognitive dysfunction in mice. Journal of Neuroinflammation, 19, 64.
Endo, F., Kasai, A., Soto, J. S., Yu, X., Qu, Z., Hashimoto, H., Gradinaru, V., Kawaguchi, R., & Khakh, B. S. (2022). Molecular basis of astrocyte diversity and morphology across the CNS in health and disease. Science, 378, eadc9020.
Enger, R., Dukefoss, D. B., Tang, W., Pettersen, K. H., Bjørnstad, D. M., Helm, P. J., Jensen, V., Sprengel, R., Vervaeke, K., Ottersen, O. P., & Nagelhus, E. A. (2017). Deletion of Aquaporin-4 curtails extracellular glutamate elevation in cortical spreading depression in awake mice. Cerebral Cortex, 27, 24-33.
Eroglu, C., Allen, N. J., Susman, M. W., O'Rourke, N. A., Park, C. Y., Ozkan, E., Chakraborty, C., Mulinyawe, S. B., Annis, D. S., Huberman, A. D., Green, E. M., Lawler, J., Dolmetsch, R., Garcia, K. C., Smith, S. J., Luo, Z. D., Rosenthal, A., Mosher, D. F., & Barres, B. A. (2009). Gabapentin receptor alpha2delta-1 is a neuronal thrombospondin receptor responsible for excitatory CNS synaptogenesis. Cell, 139, 380-392.
Etemadifar, M., Sabeti, F., Khorvash, R., Mirbagheri, M., Nouri, H., & Salari, M. (2021). Seizure incidence among neuromyelitis optica spectrum disorder patients. Revue Neurologique (Paris), 177, 655-659.
Faiz, M., Sachewsky, N., Gascón, S., Bang, K. W., Morshead, C. M., & Nagy, A. (2015). Adult neural stem cells from the subventricular zone give rise to reactive astrocytes in the cortex after stroke. Cell Stem Cell, 17, 624-634. https://doi.org/10.1016/j.stem.2015.08.002
Falcone, C., McBride, E. L., Hopkins, W. D., Hof, P. R., Manger, P. R., Sherwood, C. C., Noctor, S. C., & Martínez-Cerdeño, V. (2022). Redefining varicose projection astrocytes in primates. Glia, 70, 145-154. https://doi.org/10.1002/glia.24093
Falkowska, A., Gutowska, I., Goschorska, M., Nowacki, P., Chlubek, D., & Baranowska-Bosiacka, I. (2015). Energy metabolism of the brain, including the cooperation between astrocytes and neurons, especially in the context of glycogen metabolism. International Journal of Molecular Sciences, 16, 25959-25981. https://doi.org/10.3390/ijms161125939
Fan, J. H. (2017). Effects of HMGB1 on the migration of rat astrocytes induced by magnetic stimulation in vitro. Zhengzhou University.
Fan, H., Yang, J., Zhang, K., Xing, J., Guo, B., Mao, H., Wang, W., Hu, Y., Lin, W., Huang, Y., Ding, J., Yu, C., Fu, F., Sun, L., Wu, J., Zhao, Y., Deng, W., Zhou, C., Qiu, M., … Wang, Y. (2022). IRES-mediated Wnt2 translation in apoptotic neurons triggers astrocyte dedifferentiation. NPJ Regen Med, 7, 42.
Faraci, F. M., & Brian, J. E. Jr. (1994). Nitric oxide and the cerebral circulation. Stroke, 25, 692-703.
Farhy-Tselnicker, I., & Allen, N. J. (2018). Astrocytes, neurons, synapses: A tripartite view on cortical circuit development. Neural Development, 13, 7.
Farhy-Tselnicker, I., van Casteren, A. C. M., Lee, A., Chang, V. T., Aricescu, A. R., & Allen, N. J. (2017). Astrocyte-secreted Glypican 4 regulates release of neuronal Pentraxin 1 from axons to induce functional synapse formation. Neuron, 96, 428-445.e413.
Farizatto, K. L. G., & Baldwin, K. T. (2023). Astrocyte-synapse interactions during brain development. Current Opinion in Neurobiology, 80, 102704.
Fernández, S. P., Wasowski, C., Loscalzo, L. M., Granger, R. E., Johnston, G. A., Paladini, A. C., & Marder, M. (2006). Central nervous system depressant action of flavonoid glycosides. European Journal of Pharmacology, 539, 168-176.
Freeman, M. R. (2010). Specification and morphogenesis of astrocytes. Science, 330, 774-778.
Galindo, L. T., Mundim, M. T. V. V., Pinto, A. S., Chiarantin, G. M. D., Almeida, M. E. S., Lamers, M. L., Horwitz, A. R., Santos, M. F., & Porcionatto, M. (2018). Chondroitin sulfate impairs neural stem cell migration through ROCK activation. Molecular Neurobiology, 55, 3185-3195. https://doi.org/10.1007/s12035-017-0565-8
Gao, J., Ma, C., Xia, D., Chen, N., Zhang, J., Xu, F., Li, F., He, Y., & Gong, Q. (2023). Icariside II preconditioning evokes robust neuroprotection against ischaemic stroke, by targeting Nrf2 and the OXPHOS/NF-κB/ferroptosis pathway. British Journal of Pharmacology, 180, 308-329.
Garcia, V. J., Rushton, D. J., Tom, C. M., Allen, N. D., Kemp, P. J., Svendsen, C. N., & Mattis, V. B. (2019). Huntington's disease patient-derived astrocytes display electrophysiological impairments and reduced neuronal support. Frontiers in Neuroscience, 13, 669.
Ge, W. P., & Jia, J. M. (2016). Local production of astrocytes in the cerebral cortex. Neuroscience, 323, 3-9.
Gee, J. R., & Keller, J. N. (2005). Astrocytes: Regulation of brain homeostasis via apolipoprotein E. The International Journal of Biochemistry & Cell Biology, 37, 1145-1150.
Gharagozloo, M., Smith, M. D., Jin, J., Garton, T., Taylor, M., Chao, A., Meyers, K., Kornberg, M. D., Zack, D. J., Ohayon, J., Calabresi, B. A., Reich, D. S., Eberhart, C. G., Pardo, C. A., Kemper, C., Whartenby, K. A., & Calabresi, P. A. (2021). Complement component 3 from astrocytes mediates retinal ganglion cell loss during neuroinflammation. Acta Neuropathologica, 142, 899-915.
Ghosh, A., Comerota, M. M., Wan, D., Chen, F., Propson, N. E., Hwang, S. H., Hammock, B. D., & Zheng, H. (2020). An epoxide hydrolase inhibitor reduces neuroinflammation in a mouse model of Alzheimer's disease. Science Translational Medicine, 12, eabb1206.
Gong, Q., Lin, Y., Lu, Z., & Xiao, Z. (2020). Microglia-astrocyte cross talk through IL-18/IL-18R signaling modulates migraine-like behavior in experimental models of migraine. Neuroscience, 451, 207-215.
Gray, M. (2019). Astrocytes in Huntington's disease. Advances in Experimental Medicine and Biology, 1175, 355-381.
Guillamón-Vivancos, T., Gómez-Pinedo, U., & Matías-Guiu, J. (2015). Astrocytes in neurodegenerative diseases (I): Function and molecular description. Neurología, 30, 119-129.
Haidey, J. N., Peringod, G., Institoris, A., Gorzo, K. A., Nicola, W., Vandal, M., Ito, K., Liu, S., Fielding, C., Visser, F., Nguyen, M. D., & Gordon, G. R. (2021). Astrocytes regulate ultra-slow arteriole oscillations via stretch-mediated TRPV4-COX-1 feedback. Cell Reports, 36, 109405.
Hama, H., Hara, C., Yamaguchi, K., & Miyawaki, A. (2004). PKC signaling mediates global enhancement of excitatory synaptogenesis in neurons triggered by local contact with astrocytes. Neuron, 41, 405-415.
Hamel, E. (2006). Perivascular nerves and the regulation of cerebrovascular tone. Journal of Applied Physiology, 100(1985), 1059-1064.
Han, B., Zhang, Y., Zhang, Y., Bai, Y., Chen, X., Huang, R., Wu, F., Leng, S., Chao, J., Zhang, J. H., Hu, G., & Yao, H. (2018). Novel insight into circular RNA HECTD1 in astrocyte activation via autophagy by targeting MIR142-TIPARP: Implications for cerebral ischemic stroke. Autophagy, 14, 1164-1184.
Harris, R. A., Tindale, L., Lone, A., Singh, O., Macauley, S. L., Stanley, M., Holtzman, D. M., Bartha, R., & Cumming, R. C. (2016). Aerobic glycolysis in the frontal cortex correlates with memory performance in wild-type mice but not the APP/PS1 mouse model of cerebral amyloidosis. The Journal of Neuroscience, 36, 1871-1878.
Harrison, I. F., Ismail, O., Machhada, A., Colgan, N., Ohene, Y., Nahavandi, P., Ahmed, Z., Fisher, A., Meftah, S., Murray, T. K., Ottersen, O. P., Nagelhus, E. A., O'Neill, M. J., Wells, J. A., & Lythgoe, M. F. (2020). Impaired glymphatic function and clearance of tau in an Alzheimer's disease model. Brain, 143, 2576-2593.
Hashioka, S., Klegeris, A., & McGeer, P. L. (2012). Inhibition of human astrocyte and microglia neurotoxicity by calcium channel blockers. Neuropharmacology, 63, 685-691.
Hassel, B., Tessler, S., Faull, R. L., & Emson, P. C. (2008). Glutamate uptake is reduced in prefrontal cortex in Huntington's disease. Neurochemical Research, 33, 232-237.
Hayakawa, K., Miyamoto, N., Seo, J. H., Pham, L. D., Kim, K. W., Lo, E. H., & Arai, K. (2013). High-mobility group box 1 from reactive astrocytes enhances the accumulation of endothelial progenitor cells in damaged white matter. Journal of Neurochemistry, 125, 273-280.
Herrero-Mendez, A., Almeida, A., Fernández, E., Maestre, C., Moncada, S., & Bolaños, J. P. (2009). The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C-Cdh1. Nature Cell Biology, 11, 747-752.
Hoffmann, F. S., Hofereiter, J., Rübsamen, H., Melms, J., Schwarz, S., Faber, H., Weber, P., Pütz, B., Loleit, V., Weber, F., Hohlfeld, R., Meinl, E., & Krumbholz, M. (2015). Fingolimod induces neuroprotective factors in human astrocytes. Journal of Neuroinflammation, 12, 184.
Hua, J., Yin, N., Xu, S., Chen, Q., Tao, T., Zhang, J., Ding, J., Fan, Y., & Hu, G. (2019). Enhancing the astrocytic clearance of extracellular α-Synuclein aggregates by Ginkgolides attenuates neural cell injury. Cellular and Molecular Neurobiology, 39, 1017-1028.
Huang, J., Yang, G., Xiong, X., Wang, M., Yuan, J., Zhang, Q., Gong, C., Qiu, Z., Meng, Z., Xu, R., Chen, Q., Chen, R., Xie, L., Xie, Q., Zi, W., Jiang, G., Zhou, Y., & Yang, Q. (2020). Age-related CCL12 aggravates intracerebral hemorrhage-induced brain injury via recruitment of macrophages and T lymphocytes. Aging and Disease, 11, 1103-1115.
Huda, S., Whittam, D., Bhojak, M., Chamberlain, J., Noonan, C., & Jacob, A. (2019). Neuromyelitis optica spectrum disorders. Clinical Medicine (London, England), 19, 169-176.
Hui, Z., Zhijun, Y., Yushan, Y., Liping, C., Yiying, Z., Difan, Z., Chunglit, C. T., & Wei, C. (2020). The combination of acyclovir and dexamethasone protects against Alzheimer's disease-related cognitive impairments in mice. Psychopharmacology, 237, 1851-1860.
Huo, Q., Shi, Y., Qi, Y., Huang, L., Sui, H., & Zhao, L. (2021). Biomimetic silibinin-loaded macrophage-derived exosomes induce dual inhibition of Aβ aggregation and astrocyte activation to alleviate cognitive impairment in a model of Alzheimer's disease. Materials Science & Engineering. C, Materials for Biological Applications, 129, 112365.
Hyder, F., Patel, A. B., Gjedde, A., Rothman, D. L., Behar, K. L., & Shulman, R. G. (2006). Neuronal-glial glucose oxidation and glutamatergic-GABAergic function. Journal of Cerebral Blood Flow and Metabolism, 26, 865-877.
Jansen, L. A., Uhlmann, E. J., Crino, P. B., Gutmann, D. H., & Wong, M. (2005). Epileptogenesis and reduced inward rectifier potassium current in tuberous sclerosis complex-1-deficient astrocytes. Epilepsia, 46, 1871-1880.
Janssens, R., Struyf, S., & Proost, P. (2018). The unique structural and functional features of CXCL12. Cellular & Molecular Immunology, 15, 299-311.
Jiang, R., Diaz-Castro, B., Looger, L. L., & Khakh, B. S. (2016). Dysfunctional calcium and glutamate signaling in striatal astrocytes from Huntington's disease model mice. The Journal of Neuroscience, 36, 3453-3470.
Jing, H., Wang, S., Wang, M., Fu, W., Zhang, C., & Xu, D. (2017). Isobavachalcone attenuates MPTP-induced Parkinson's disease in mice by inhibition of microglial activation through NF-κB pathway. PLoS ONE, 12, e0169560.
Jones, E. V., Bernardinelli, Y., Zarruk, J. G., Chierzi, S., & Murai, K. K. (2018). SPARC and GluA1-containing AMPA receptors promote neuronal health following CNS injury. Frontiers in Cellular Neuroscience, 12, 22.
Kaye, J., Piryatinsky, V., Birnberg, T., Hingaly, T., Raymond, E., Kashi, R., Amit-Romach, E., Caballero, I. S., Towfic, F., Ator, M. A., Rubinstein, E., Laifenfeld, D., Orbach, A., Shinar, D., Marantz, Y., Grossman, I., Knappertz, V., Hayden, M. R., & Laufer, R. (2016). Laquinimod arrests experimental autoimmune encephalomyelitis by activating the aryl hydrocarbon receptor. Proceedings of the National Academy of Sciences of the United States of America, 113, E6145-e6152.
Kettenmann, H., & Verkhratsky, A. (2011). Neuroglia-Living nerve glue. Fortschritte der Neurologie-Psychiatrie, 79, 588-597.
Kilic, K., Karatas, H., Dönmez-Demir, B., Eren-Kocak, E., Gursoy-Ozdemir, Y., Can, A., Petit, J. M., Magistretti, P. J., & Dalkara, T. (2018). Inadequate brain glycogen or sleep increases spreading depression susceptibility. Annals of Neurology, 83, 61-73.
Kim, A., Lalonde, K., Truesdell, A., Gomes Welter, P., Brocardo, P. S., Rosenstock, T. R., & Gil-Mohapel, J. (2021). New avenues for the treatment of Huntington's disease. International Journal of Molecular Sciences, 22, 8363.
Kim, J., Lee, H. J., Park, S. K., Park, J. H., Jeong, H. R., Lee, S., Lee, H., Seol, E., & Hoe, H. S. (2021). Donepezil regulates LPS and Aβ-stimulated Neuroinflammation through MAPK/NLRP3 Inflammasome/STAT3 signaling. International Journal of Molecular Sciences, 22, 10637.
Kucheryavykh, L. Y., Kucheryavykh, Y. V., Inyushin, M., Shuba, Y. M., Sanabria, P., Cubano, L. A., Skatchkov, S. N., & Eaton, M. J. (2009). Ischemia increases TREK-2 channel expression in astrocytes: Relevance to glutamate clearance. Open Neuroscience Journal, 3, 40-47.
Kumar, V. (2019). Toll-like receptors in the pathogenesis of neuroinflammation. Journal of Neuroimmunology, 332, 16-30.
Lauritzen, M., & Hansen, A. J. (1992). The effect of glutamate receptor blockade on anoxic depolarization and cortical spreading depression. Journal of Cerebral Blood Flow and Metabolism, 12, 223-229.
Lebedeva, A., Plata, A., Nosova, O., Tyurikova, O., & Semyanov, A. (2018). Activity-dependent changes in transporter and potassium currents in hippocampal astrocytes. Brain Research Bulletin, 136, 37-43.
Lee, Y., Chun, H. J., Lee, K. M., Jung, Y. S., & Lee, J. (2015). Silibinin suppresses astroglial activation in a mouse model of acute Parkinson's disease by modulating the ERK and JNK signaling pathways. Brain Research, 1627, 233-242. https://doi.org/10.1016/j.brainres.2015.09.029
Lee, H. J., Dreyfus, C., & DiCicco-Bloom, E. (2016). Valproic acid stimulates proliferation of glial precursors during cortical gliogenesis in developing rat. Developmental Neurobiology, 76, 780-798. https://doi.org/10.1002/dneu.22359
Lee, J. H., Kim, J. Y., Noh, S., Lee, H., Lee, S. Y., Mun, J. Y., Park, H., & Chung, W. S. (2021). Astrocytes phagocytose adult hippocampal synapses for circuit homeostasis. Nature, 590, 612-617. https://doi.org/10.1038/s41586-020-03060-3
Lee, E. Y., Lee, Z. H., & Song, Y. W. (2009). CXCL10 and autoimmune diseases. Autoimmunity Reviews, 8, 379-383.
Lee, H. G., Wheeler, M. A., & Quintana, F. J. (2022). Function and therapeutic value of astrocytes in neurological diseases. Nature Reviews. Drug Discovery, 21, 339-358.
Lee, J. H., Yang, D. S., Goulbourne, C. N., Im, E., Stavrides, P., Pensalfini, A., Chan, H., Bouchet-Marquis, C., Bleiwas, C., Berg, M. J., Huo, C., Peddy, J., Pawlik, M., Levy, E., Rao, M., Staufenbiel, M., & Nixon, R. A. (2022). Faulty autolysosome acidification in Alzheimer's disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaques. Nature Neuroscience, 25, 688-701.
Lei, S., He, Y., Zhu, Z., Liu, Z., Lin, Y., He, Y., Du, S., Chen, X., Xu, P., & Zhu, X. (2020). Inhibition of NMDA receptors downregulates astrocytic AQP4 to suppress seizures. Cellular and Molecular Neurobiology, 40, 1283-1295.
Li, W., Liu, J., Tan, W., & Zhou, Y. (2021). The role and mechanisms of microglia in neuromyelitis optica spectrum disorders. International Journal of Medical Sciences, 18, 3059-3065. https://doi.org/10.7150/ijms.61153
Li, Y., Ma, T., Zhu, X., Zhang, M., Zhao, L., Wang, P., & Liang, J. (2022). Zinc improves neurological recovery by promoting angiogenesis via the astrocyte-mediated HIF-1α/VEGF signaling pathway in experimental stroke. CNS Neuroscience & Therapeutics, 28, 1790-1799. https://doi.org/10.1111/cns.13918
Li, Z. W., Song, Y. Y., He, T. T., Wen, R. X., Li, Y. F., Chen, T. T., Huang, S. X., Wang, Y. T., Tang, Y. H., Shen, F. X., Tian, H. L., Yang, G. Y., & Zhang, Z. J. (2021). M2 microglial small extracellular vesicles reduce glial scar formation via the miR-124/STAT3 pathway after ischemic stroke in mice. Theranostics, 11, 1232-1248. https://doi.org/10.7150/thno.48761
Li, J., Ye, X., Zhou, Y., Peng, S., Zheng, P., Zhang, X., Yang, J., & Xu, Y. (2022). Energy metabolic disorder of astrocytes may be an inducer of migraine attack. Brain Sciences, 12, 844.
Liao, J., Tian, X., Wang, H., & Xiao, Z. (2018). Epilepsy and migraine-Are they comorbidity? Genes & Diseases, 5, 112-118.
Liauw, J., Hoang, S., Choi, M., Eroglu, C., Choi, M., Sun, G. H., Percy, M., Wildman-Tobriner, B., Bliss, T., Guzman, R. G., Barres, B. A., & Steinberg, G. K. (2008). Thrombospondins 1 and 2 are necessary for synaptic plasticity and functional recovery after stroke. Journal of Cerebral Blood Flow and Metabolism, 28, 1722-1732.
Linker, R. A., & Haghikia, A. (2016). Dimethyl fumarate in multiple sclerosis: Latest developments, evidence and place in therapy. Therapeutic Advances in Chronic Disease, 7, 198-207.
Linnerbauer, M., Wheeler, M. A., & Quintana, F. J. (2020). Astrocyte crosstalk in CNS inflammation. Neuron, 108, 608-622.
Liu, Y., Chu, S., Hu, Y., Yang, S., Li, X., Zheng, Q., Ai, Q., Ren, S., Wang, H., Gong, L., Xu, X., & Chen, N. H. (2021). Exogenous adenosine antagonizes excitatory amino acid toxicity in primary astrocytes. Cellular and Molecular Neurobiology, 41, 687-704. https://doi.org/10.1007/s10571-020-00876-5
Liu, Y., Wang, L., Long, Z., Zeng, L., & Wu, Y. (2012). Protoplasmic astrocytes enhance the ability of neural stem cells to differentiate into neurons in vitro. PLoS ONE, 7, e38243. https://doi.org/10.1371/journal.pone.0038243
Liu, M., Xu, Z., Wang, L., Zhang, L., Liu, Y., Cao, J., Fu, Q., Liu, Y., Li, H., Lou, J., Hou, W., Mi, W., & Ma, Y. (2020). Cottonseed oil alleviates ischemic stroke injury by inhibiting the inflammatory activation of microglia and astrocyte. Journal of Neuroinflammation, 17, 270.
Lv, T., Zhao, B., Hu, Q., & Zhang, X. (2021). The glymphatic system: A novel therapeutic target for stroke treatment. Frontiers in Aging Neuroscience, 13, 689098.
Magistretti, P. J., & Allaman, I. (2015). A cellular perspective on brain energy metabolism and functional imaging. Neuron, 86, 883-901.
Maitra, U., & Li, L. (2013). Molecular mechanisms responsible for the reduced expression of cholesterol transporters from macrophages by low-dose endotoxin. Arteriosclerosis, Thrombosis, and Vascular Biology, 33, 24-33.
Marschollek, C., Karimzadeh, F., Jafarian, M., Ahmadi, M., Mohajeri, S. M., Rahimi, S., Speckmann, E. J., & Gorji, A. (2017). Effects of garlic extract on spreading depression: In vitro and in vivo investigations. Nutritional Neuroscience, 20, 127-134.
Martin, M., Vermeiren, S., Bostaille, N., Eubelen, M., Spitzer, D., Vermeersch, M., Profaci, C. P., Pozuelo, E., Toussay, X., Raman-Nair, J., Tebabi, P., America, M., de Groote, A., Sanderson, L. E., Cabochette, P., Germano, R. F. V., Torres, D., Boutry, S., de Kerchove d'Exaerde, A., … Vanhollebeke, B. (2022). Engineered Wnt ligands enable blood-brain barrier repair in neurological disorders. Science, 375, eabm4459.
Masvekar, R., Kosa, P., Barbour, C., Milstein, J. L., & Bielekova, B. (2022). Drug library screen identifies inhibitors of toxic astrogliosis. Multiple Sclerosis and Related Disorders, 58, 103499.
Meinl, E., Aloisi, F., Ertl, B., Weber, F., de Waal Malefyt, R., Wekerle, H., & Hohlfeld, R. (1994). Multiple sclerosis. Immunomodulatory effects of human astrocytes on T cells. Brain, 117(Pt 6), 1323-1332.
Meyer-Franke, A., Kaplan, M. R., Pfrieger, F. W., & Barres, B. A. (1995). Characterization of the signaling interactions that promote the survival and growth of developing retinal ganglion cells in culture. Neuron, 15, 805-819.
Miyazaki, I., & Asanuma, M. (2020). Neuron-astrocyte interactions in Parkinson's disease. Cell, 9, 2623.
Miyazaki, I., Asanuma, M., Kikkawa, Y., Takeshima, M., Murakami, S., Miyoshi, K., Sogawa, N., & Kita, T. (2011). Astrocyte-derived metallothionein protects dopaminergic neurons from dopamine quinone toxicity. Glia, 59, 435-451.
Mizee, M. R., Wooldrik, D., Lakeman, K. A., van het Hof, B., Drexhage, J. A., Geerts, D., Bugiani, M., Aronica, E., Mebius, R. E., Prat, A., de Vries, H. E., & Reijerkerk, A. (2013). Retinoic acid induces blood-brain barrier development. The Journal of Neuroscience, 33, 1660-1671.
Moretti, D., Tambone, S., Cerretani, M., Fezzardi, P., Missineo, A., Sherman, L. T., Munoz-Sajuan, I., Harper, S., Dominquez, C., Pacifici, R., Tomei, L., Park, L., & Bresciani, A. (2021). NRF2 activation by reversible KEAP1 binding induces the antioxidant response in primary neurons and astrocytes of a Huntington's disease mouse model. Free Radical Biology & Medicine, 162, 243-254.
Motawi, T. K., Al-Kady, R. H., Abdelraouf, S. M., & Senousy, M. A. (2022). Empagliflozin alleviates endoplasmic reticulum stress and augments autophagy in rotenone-induced Parkinson's disease in rats: Targeting the GRP78/PERK/eIF2α/CHOP pathway and miR-211-5p. Chemico-Biological Interactions, 362, 110002.
Moyon, S., Dubessy, A. L., Aigrot, M. S., Trotter, M., Huang, J. K., Dauphinot, L., Potier, M. C., Kerninon, C., Melik Parsadaniantz, S., Franklin, R. J., & Lubetzki, C. (2015). Demyelination causes adult CNS progenitors to revert to an immature state and express immune cues that support their migration. The Journal of Neuroscience, 35, 4-20.
Mulligan, S. J., & MacVicar, B. A. (2004). Calcium transients in astrocyte endfeet cause cerebrovascular constrictions. Nature, 431, 195-199.
Myer, D. J., Gurkoff, G. G., Lee, S. M., Hovda, D. A., & Sofroniew, M. V. (2006). Essential protective roles of reactive astrocytes in traumatic brain injury. Brain, 129, 2761-2772.
Neal, M. L., Boyle, A. M., Budge, K. M., Safadi, F. F., & Richardson, J. R. (2018). The glycoprotein GPNMB attenuates astrocyte inflammatory responses through the CD44 receptor. Journal of Neuroinflammation, 15, 73. https://doi.org/10.1186/s12974-018-1100-1
Neal, M., Luo, J., Harischandra, D. S., Gordon, R., Sarkar, S., Jin, H., Anantharam, V., Désaubry, L., Kanthasamy, A., & Kanthasamy, A. (2018). Prokineticin-2 promotes chemotaxis and alternative A2 reactivity of astrocytes. Glia, 66, 2137-2157.
Nguyen, J. V., Soto, I., Kim, K. Y., Bushong, E. A., Oglesby, E., Valiente-Soriano, F. J., Yang, Z., Davis, C. H., Bedont, J. L., Son, J. L., Wei, J. O., Buchman, V. L., Zack, D. J., Vidal-Sanz, M., Ellisman, M. H., & Marsh-Armstrong, N. (2011). Myelination transition zone astrocytes are constitutively phagocytic and have synuclein dependent reactivity in glaucoma. Proceedings of the National Academy of Sciences of the United States of America, 108, 1176-1181. https://doi.org/10.1073/pnas.1013965108
Nguyen, A. Q., Sutley, S., Koeppen, J., Mina, K., Woodruff, S., Hanna, S., Vengala, A., Hickmott, P. W., Obenaus, A., & Ethell, I. M. (2020). Astrocytic Ephrin-B1 controls excitatory-inhibitory balance in developing Hippocampus. The Journal of Neuroscience, 40, 6854-6871.
Nishida, H., & Okabe, S. (2007). Direct astrocytic contacts regulate local maturation of dendritic spines. The Journal of Neuroscience, 27, 331-340.
Noorbakhsh, F., Ellestad, K. K., Maingat, F., Warren, K. G., Han, M. H., Steinman, L., Baker, G. B., & Power, C. (2011). Impaired neurosteroid synthesis in multiple sclerosis. Brain, 134(9), 2703-2721. https://doi.org/10.1093/brain/awr200
Obermeier, B., Daneman, R., & Ransohoff, R. M. (2013). Development, maintenance and disruption of the blood-brain barrier. Nature Medicine, 19, 1584-1596.
Overman, J. J., Clarkson, A. N., Wanner, I. B., Overman, W. T., Eckstein, I., Maguire, J. L., Dinov, I. D., Toga, A. W., & Carmichael, S. T. (2012). A role for ephrin-A5 in axonal sprouting, recovery, and activity-dependent plasticity after stroke. Proceedings of the National Academy of Sciences of the United States of America, 109, E2230-E2239.
Padmashri, R., Ren, B., Oldham, B., Jung, Y., Gough, R., & Dunaevsky, A. (2021). Modeling human-specific interlaminar astrocytes in the mouse cerebral cortex. The Journal of Comparative Neurology, 529, 802-810.
Palpagama, T. H., Waldvogel, H. J., Faull, R. L. M., & Kwakowsky, A. (2019). The role of microglia and astrocytes in Huntington's disease. Frontiers in Molecular Neuroscience, 12, 258.
Pandey, M., & Rajamma, U. (2018). Huntington's disease: The coming of age. Journal of Genetics, 97, 649-664.
Papadopoulos, M. C., Manley, G. T., Krishna, S., & Verkman, A. S. (2004). Aquaporin-4 facilitates reabsorption of excess fluid in vasogenic brain edema. The FASEB Journal, 18, 1291-1293.
Papouin, T., Dunphy, J., Tolman, M., Foley, J. C., & Haydon, P. G. (2017). Astrocytic control of synaptic function. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 372, 20160154.
Park, M. W., Cha, H. W., Kim, J., Kim, J. H., Yang, H., Yoon, S., Boonpraman, N., Yi, S. S., Yoo, I. D., & Moon, J. S. (2021). NOX4 promotes ferroptosis of astrocytes by oxidative stress-induced lipid peroxidation via the impairment of mitochondrial metabolism in Alzheimer's diseases. Redox Biology, 41, 101947.
Passaponti, S., Ermini, L., Acconci, G., Severi, F. M., Romagnoli, R., Cutrupi, S., Clerico, M., Guerrera, G., & Ietta, F. (2022). Rank-Rankl-Opg Axis in multiple sclerosis: The contribution of placenta. Cell, 11, 1357.
Patel, D. C., Tewari, B. P., Chaunsali, L., & Sontheimer, H. (2019). Neuron-glia interactions in the pathophysiology of epilepsy. Nature Reviews. Neuroscience, 20, 282-297.
Paul, D., Ge, S., Lemire, Y., Jellison, E. R., Serwanski, D. R., Ruddle, N. H., & Pachter, J. S. (2014). Cell-selective knockout and 3D confocal image analysis reveals separate roles for astrocyte-and endothelial-derived CCL2 in neuroinflammation. Journal of Neuroinflammation, 11, 10.
Pearson, C. S., Solano, A. G., Tilve, S. M., Mencio, C. P., Martin, K. R., & Geller, H. M. (2020). Spatiotemporal distribution of chondroitin sulfate proteoglycans after optic nerve injury in rodents. Experimental Eye Research, 190, 107859.
Pekny, M., Wilhelmsson, U., Tatlisumak, T., & Pekna, M. (2019). Astrocyte activation and reactive gliosis-A new target in stroke? Neuroscience Letters, 689, 45-55.
Pelvig, D. P., Pakkenberg, H., Stark, A. K., & Pakkenberg, B. (2008). Neocortical glial cell numbers in human brains. Neurobiology of Aging, 29, 1754-1762.
Pérez-Sánchez, A., Cuyàs, E., Ruiz-Torres, V., Agulló-Chazarra, L., Verdura, S., González-Álvarez, I., Bermejo, M., Joven, J., Micol, V., Bosch-Barrera, J., & Menendez, J. A. (2019). Intestinal permeability study of clinically relevant formulations of Silibinin in Caco-2 cell monolayers. International Journal of Molecular Sciences, 20, 1606.
Perucho, J., Gómez, A., Muñoz, M. P., de Yébenes, J. G., Mena, M., & Casarejos, M. J. (2016). Trehalose rescues glial cell dysfunction in striatal cultures from HD R6/1 mice at early postnatal development. Molecular and Cellular Neurosciences, 74, 128-145.
Phares, T. W., Stohlman, S. A., Hinton, D. R., & Bergmann, C. C. (2013). Astrocyte-derived CXCL10 drives accumulation of antibody-secreting cells in the central nervous system during viral encephalomyelitis. Journal of Virology, 87, 3382-3392.
Pola, R., Ling, L. E., Silver, M., Corbley, M. J., Kearney, M., Blake Pepinsky, R., Shapiro, R., Taylor, F. R., Baker, D. P., Asahara, T., & Isner, J. M. (2001). The morphogen sonic hedgehog is an indirect angiogenic agent upregulating two families of angiogenic growth factors. Nature Medicine, 7, 706-711.
Ponath, G., Park, C., & Pitt, D. (2018). The role of astrocytes in multiple sclerosis. Frontiers in Immunology, 9, 217.
Ragheb, S., Li, Y., Simon, K., VanHaerents, S., Galimberti, D., de Riz, M., Fenoglio, C., Scarpini, E., & Lisak, R. (2011). Multiple sclerosis: BAFF and CXCL13 in cerebrospinal fluid. Multiple Sclerosis, 17, 819-829.
Rasmussen, R. N., & Smith, N. A. (2022). The elusive varicose astrocytes. Trends in Neurosciences, 45, 94-95.
Reboldi, A., Coisne, C., Baumjohann, D., Benvenuto, F., Bottinelli, D., Lira, S., Uccelli, A., Lanzavecchia, A., Engelhardt, B., & Sallusto, F. (2009). C-C chemokine receptor 6-regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE. Nature Immunology, 10, 514-523.
Reichenbach, A., & Bringmann, A. (2013). New functions of Müller cells. Glia, 61, 651-678.
Risher, W. C., Patel, S., Kim, I. H., Uezu, A., Bhagat, S., Wilton, D. K., Pilaz, L. J., Singh Alvarado, J., Calhan, O. Y., Silver, D. L., Stevens, B., Calakos, N., Soderling, S. H., & Eroglu, C. (2014). Astrocytes refine cortical connectivity at dendritic spines. eLife, 3, e04047.
Rogatzki, M. J., Ferguson, B. S., Goodwin, M. L., & Gladden, L. B. (2015). Lactate is always the end product of glycolysis. Frontiers in Neuroscience, 9, 22.
Romoli, M., Mazzocchetti, P., D'Alonzo, R., Siliquini, S., Rinaldi, V. E., Verrotti, A., Calabresi, P., & Costa, C. (2019). Valproic acid and epilepsy: From molecular mechanisms to clinical evidences. Current Neuropharmacology, 17, 926-946.
Rothhammer, V., Mascanfroni, I. D., Bunse, L., Takenaka, M. C., Kenison, J. E., Mayo, L., Chao, C. C., Patel, B., Yan, R., Blain, M., Alvarez, J. I., Kébir, H., Anandasabapathy, N., Izquierdo, G., Jung, S., Obholzer, N., Pochet, N., Clish, C. B., Prinz, M., … Quintana, F. J. (2016). Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor. Nature Medicine, 22, 586-597.
Rothhammer, V., & Quintana, F. J. (2015). Control of autoimmune CNS inflammation by astrocytes. Seminars in Immunopathology, 37, 625-638.
Sajja, V. S., Hlavac, N., & VandeVord, P. J. (2016). Role of glia in memory deficits following traumatic brain injury: Biomarkers of glia dysfunction. Frontiers in Integrative Neuroscience, 10, 7.
Sánchez Gomar, I., Díaz Sánchez, M., Uclés Sánchez, A. J., Casado Chocán, J. L., Suárez-Luna, N., Ramírez-Lorca, R., Villadiego, J., Toledo-Aral, J. J., & Echevarría, M. (2016). Comparative analysis for the presence of IgG anti-Aquaporin-1 in patients with NMO-Spectrum disorders. International Journal of Molecular Sciences, 17, 1195.
Sancho, L., Contreras, M., & Allen, N. J. (2021). Glia as sculptors of synaptic plasticity. Neuroscience Research, 167, 17-29.
Schafer, D. P., Lehrman, E. K., Kautzman, A. G., Koyama, R., Mardinly, A. R., Yamasaki, R., Ransohoff, R. M., Greenberg, M. E., Barres, B. A., & Stevens, B. (2012). Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner. Neuron, 74, 691-705.
Scheltens, P., de Strooper, B., Kivipelto, M., Holstege, H., Chételat, G., Teunissen, C. E., Cummings, J., & van der Flier, W. M. (2021). Alzheimer's disease. Lancet, 397, 1577-1590.
Segarra, M., Kirchmaier, B. C., & Acker-Palmer, A. (2015). A vascular perspective on neuronal migration. Mechanisms of Development, 138(Pt 1), 17-25.
Shinozaki, Y., Shibata, K., Yoshida, K., Shigetomi, E., Gachet, C., Ikenaka, K., Tanaka, K. F., & Koizumi, S. (2017). Transformation of astrocytes to a neuroprotective phenotype by microglia via P2Y(1) receptor downregulation. Cell Reports, 19, 1151-1164.
Silver, J., Schwab, M. E., & Popovich, P. G. (2014). Central nervous system regenerative failure: Role of oligodendrocytes, astrocytes, and microglia. Cold Spring Harbor Perspectives in Biology, 7, a020602.
Singh, S. K., Stogsdill, J. A., Pulimood, N. S., Dingsdale, H., Kim, Y. H., Pilaz, L. J., Kim, I. H., Manhaes, A. C., Rodrigues, W. S. Jr., Pamukcu, A., Enustun, E., Ertuz, Z., Scheiffele, P., Soderling, S. H., Silver, D. L., Ji, R. R., Medina, A. E., & Eroglu, C. (2016). Astrocytes assemble Thalamocortical synapses by bridging NRX1α and NL1 via Hevin. Cell, 164, 183-196.
Sofroniew, M. V. (2009). Molecular dissection of reactive astrogliosis and glial scar formation. Trends in Neurosciences, 32, 638-647.
Sonninen, T. M., Hämäläinen, R. H., Koskuvi, M., Oksanen, M., Shakirzyanova, A., Wojciechowski, S., Puttonen, K., Naumenko, N., Goldsteins, G., Laham-Karam, N., Lehtonen, M., Tavi, P., Koistinaho, J., & Lehtonen, Š. (2020). Metabolic alterations in Parkinson's disease astrocytes. Scientific Reports, 10, 14474.
Soria Lopez, J. A., González, H. M., & Léger, G. C. (2019). Alzheimer's disease. Handbook of Clinical Neurology, 167, 231-255.
Stephen, T. L., Gupta-Agarwal, S., & Kittler, J. T. (2014). Mitochondrial dynamics in astrocytes. Biochemical Society Transactions, 42, 1302-1310.
Stevens, B., Allen, N. J., Vazquez, L. E., Howell, G. R., Christopherson, K. S., Nouri, N., Micheva, K. D., Mehalow, A. K., Huberman, A. D., Stafford, B., Sher, A., Litke, A. M., Lambris, J. D., Smith, S. J., John, S. W., & Barres, B. A. (2007). The classical complement cascade mediates CNS synapse elimination. Cell, 131, 1164-1178.
Su, Z., Yuan, Y., Chen, J., Cao, L., Zhu, Y., Gao, L., Qiu, Y., & He, C. (2009). Reactive astrocytes in glial scar attract olfactory ensheathing cells migration by secreted TNF-alpha in spinal cord lesion of rat. PLoS ONE, 4, e8141. https://doi.org/10.1371/journal.pone.0008141
Su, X. M., & Zhang, D. S. (2021). Discussion of astrocytic mitochondria as a therapeutic target for ischemic stroke. J Hebei University of Science and Technology, 42, 400-409.
Suganya, S. N., & Sumathi, T. (2017). Effect of rutin against a mitochondrial toxin, 3-nitropropionicacid induced biochemical, behavioral and histological alterations-a pilot study on Huntington's disease model in rats. Metabolic Brain Disease, 32, 471-481.
Sun, M. F., Zhu, Y. L., Zhou, Z. L., Jia, X. B., Xu, Y. D., Yang, Q., Cui, C., & Shen, Y. Q. (2018). Neuroprotective effects of fecal microbiota transplantation on MPTP-induced Parkinson's disease mice: Gut microbiota, glial reaction and TLR4/TNF-α signaling pathway. Brain, Behavior, and Immunity, 70, 48-60.
Taguchi, T., Ikuno, M., Yamakado, H., & Takahashi, R. (2020). Animal model for prodromal Parkinson's disease. International Journal of Molecular Sciences, 21, 1961.
Takeshita, Y., Fujikawa, S., Serizawa, K., Fujisawa, M., Matsuo, K., Nemoto, J., Shimizu, F., Sano, Y., Tomizawa-Shinohara, H., Miyake, S., Ransohoff, R. M., & Kanda, T. (2021). New BBB model reveals that IL-6 blockade suppressed the BBB disorder, preventing onset of NMOSD. Neurology Neuroimmunology & Neuroinflammation, 8, e1076.
Tanuma, N., Sakuma, H., Sasaki, A., & Matsumoto, Y. (2006). Chemokine expression by astrocytes plays a role in microglia/macrophage activation and subsequent neurodegeneration in secondary progressive multiple sclerosis. Acta Neuropathologica, 112, 195-204.
Tian, G. F., Azmi, H., Takano, T., Xu, Q., Peng, W., Lin, J., Oberheim, N., Lou, N., Wang, X., Zielke, H. R., Kang, J., & Nedergaard, M. (2005). An astrocytic basis of epilepsy. Nature Medicine, 11, 973-981.
Tomimoto, H., Akiguchi, I., Wakita, H., Kimura, J., Hori, K., & Yodoi, J. (1993). Astroglial expression of ATL-derived factor, a human thioredoxin homologue, in the gerbil brain after transient global ischemia. Brain Research, 625, 1-8.
Tsai, H. I., Tsai, L. H., Chen, M. Y., & Chou, Y. C. (2006). Cholesterol deficiency perturbs actin signaling and glutamate homeostasis in hippocampal astrocytes. Brain Research, 1104, 27-38.
Ullian, E. M., Sapperstein, S. K., Christopherson, K. S., & Barres, B. A. (2001). Control of synapse number by glia. Science, 291, 657-661.
Vainchtein, I. D., Chin, G., Cho, F. S., Kelley, K. W., Miller, J. G., Chien, E. C., Liddelow, S. A., Nguyen, P. T., Nakao-Inoue, H., Dorman, L. C., Akil, O., Joshita, S., Barres, B. A., Paz, J. T., Molofsky, A. B., & Molofsky, A. V. (2018). Astrocyte-derived interleukin-33 promotes microglial synapse engulfment and neural circuit development. Science, 359, 1269-1273.
Valenta, T., Hausmann, G., & Basler, K. (2012). The many faces and functions of β-catenin. The EMBO Journal, 31, 2714-2736.
Valenza, M., Carroll, J. B., Leoni, V., Bertram, L. N., Björkhem, I., Singaraja, R. R., di Donato, S., Lutjohann, D., Hayden, M. R., & Cattaneo, E. (2007). Cholesterol biosynthesis pathway is disturbed in YAC128 mice and is modulated by huntingtin mutation. Human Molecular Genetics, 16, 2187-2198.
Valenza, M., & Cattaneo, E. (2011). Emerging roles for cholesterol in Huntington's disease. Trends in Neurosciences, 34, 474-486.
Vasile, F., Dossi, E., & Rouach, N. (2017). Human astrocytes: Structure and functions in the healthy brain. Brain Structure & Function, 222, 2017-2029.
Vistoli, G., de Maddis, D., Cipak, A., Zarkovic, N., Carini, M., & Aldini, G. (2013). Advanced glycoxidation and lipoxidation end products (AGEs and ALEs): An overview of their mechanisms of formation. Free Radical Research, 47(Suppl 1), 3-27.
Voskuhl, R. R., Peterson, R. S., Song, B., Ao, Y., Morales, L. B., Tiwari-Woodruff, S., & Sofroniew, M. V. (2009). Reactive astrocytes form scar-like perivascular barriers to leukocytes during adaptive immune inflammation of the CNS. The Journal of Neuroscience, 29, 11511-11522.
Walker-Caulfield, M. E., Guo, Y., Johnson, R. K., McCarthy, C. B., Fitz-Gibbon, P. D., Lucchinetti, C. F., & Howe, C. L. (2015). NFκB signaling drives pro-granulocytic astroglial responses to neuromyelitis optica patient IgG. Journal of Neuroinflammation, 12, 185.
Wang, Y., Bian, J., Yao, M., Du, L., Xu, Y., Chang, H., Cong, H., Wei, Y., Xu, W., Wang, H., Zhang, X., Geng, X., & Yin, L. (2023). Targeting chemoattractant chemokine (C-C motif) ligand 2 derived from astrocytes is a promising therapeutic approach in the treatment of neuromyelitis optica spectrum disorders. Frontiers in Immunology, 14, 1144532. https://doi.org/10.3389/fimmu.2023.1144532
Wang, G., Wang, R., Kong, W., & Zhang, J. (2020). The relationship between sparseness and energy consumption of neural networks. Neural Plasticity, 2020, 8848901.
Wang, J., Wang, S., Sun, M., Xu, H., Liu, W., Wang, D., Zhang, L., Li, Y., Cao, J., Li, F., & Li, M. (2020). Identification of geraldol as an inhibitor of aquaporin-4 binding by NMO-IgG. Molecular Medicine Reports, 22, 1111-1118.
Wang, L., Zhang, Y. L., Lin, Q. Y., Liu, Y., Guan, X. M., Ma, X. L., Cao, H. J., Liu, Y., Bai, J., Xia, Y. L., Du, J., & Li, H. H. (2018). CXCL1-CXCR2 axis mediates angiotensin II-induced cardiac hypertrophy and remodelling through regulation of monocyte infiltration. European Heart Journal, 39, 1818-1831.
Wanner, I. B., Anderson, M. A., Song, B., Levine, J., Fernandez, A., Gray-Thompson, Z., Ao, Y., & Sofroniew, M. V. (2013). Glial scar borders are formed by newly proliferated, elongated astrocytes that interact to corral inflammatory and fibrotic cells via STAT3-dependent mechanisms after spinal cord injury. The Journal of Neuroscience, 33, 12870-12886.
Wheeler, M. A., Clark, I. C., Tjon, E. C., Li, Z., Zandee, S. E. J., Couturier, C. P., Watson, B. R., Scalisi, G., Alkwai, S., Rothhammer, V., Rotem, A., Heyman, J. A., Thaploo, S., Sanmarco, L. M., Ragoussis, J., Weitz, D. A., Petrecca, K., Moffitt, J. R., Becher, B., … Quintana, F. J. (2020). MAFG-driven astrocytes promote CNS inflammation. Nature, 578, 593-599.
Wilton, D. K., Dissing-Olesen, L., & Stevens, B. (2019). Neuron-Glia Signaling in Synapse Elimination. Annual Review of Neuroscience, 42, 107-127.
Woo, D. H., Han, K. S., Shim, J. W., Yoon, B. E., Kim, E., Bae, J. Y., Oh, S. J., Hwang, E. M., Marmorstein, A. D., Bae, Y. C., Park, J. Y., & Lee, C. J. (2012). TREK-1 and Best1 channels mediate fast and slow glutamate release in astrocytes upon GPCR activation. Cell, 151, 25-40.
Wosik, K., Cayrol, R., Dodelet-Devillers, A., Berthelet, F., Bernard, M., Moumdjian, R., Bouthillier, A., Reudelhuber, T. L., & Prat, A. (2007). Angiotensin II controls occludin function and is required for blood brain barrier maintenance: Relevance to multiple sclerosis. The Journal of Neuroscience, 27, 9032-9042.
Wu, T. T., Su, F. J., Feng, Y. Q., Liu, B., Li, M. Y., Liang, F. Y., Li, G., Li, X. J., Zhang, Y., Cai, Z. Q., & Pei, Z. (2020). Mesenchymal stem cells alleviate AQP-4-dependent glymphatic dysfunction and improve brain distribution of antisense oligonucleotides in BACHD mice. Stem Cells, 38, 218-230.
Xia, M. L., Xie, X. H., Ding, J. H., Du, R. H., & Hu, G. (2020). Astragaloside IV inhibits astrocyte senescence: Implication in Parkinson's disease. Journal of Neuroinflammation, 17, 105.
Xie, Y., Kuan, A. T., Wang, W., Herbert, Z. T., Mosto, O., Olukoya, O., Adam, M., Vu, S., Kim, M., Tran, D., Gómez, N., Charpentier, C., Sorour, I., Lacey, T. E., Tolstorukov, M. Y., Sabatini, B. L., Lee, W. A., & Harwell, C. C. (2022). Astrocyte-neuron crosstalk through hedgehog signaling mediates cortical synapse development. Cell Reports, 38, 110416.
Xu, L., Ding, L., Su, Y., Shao, R., Liu, J., & Huang, Y. (2019). Neuroprotective effects of curcumin against rats with focal cerebral ischemia-reperfusion injury. International Journal of Molecular Medicine, 43, 1879-1887. https://doi.org/10.3892/ijmm.2019.4094
Xu, H., Gong, Y., Jiao, Y., Guo, J., Zhao, L., Yang, J., Tong, H., Sun, M., & Li, M. (2023). Inhibition of Neuromyelitis Optica immunoglobulin G binding to Aquaporin-4 by the small molecule blocker Melanthioidine. Current Pharmaceutical Design, 29, 793-802.
Xu, L., Hu, G., Xing, P., Zhou, M., & Wang, D. (2021). Corrigendum to “paclitaxel alleviates the sepsis-induced acute kidney injury via lnc-MALAT1/miR-370-3p/HMGB1 axis” [Life Sci. 2020 Dec 1; 262:118505. Doi:10.1016/j.lfs.2020.118505. Epub 2020 Sep 28]. Life Sciences, 272, 119159.
Xu, J., Ji, T., Li, G., Zhang, H., Zheng, Y., Li, M., Ma, J., Li, Y., & Chi, G. (2022). Lactate attenuates astrocytic inflammation by inhibiting ubiquitination and degradation of NDRG2 under oxygen-glucose deprivation conditions. Journal of Neuroinflammation, 19, 314. https://doi.org/10.1186/s12974-022-02678-6
Xu, H., Yang, Y., Tang, X., Zhao, M., Liang, F., Xu, P., Hou, B., Xing, Y., Bao, X., & Fan, X. (2013). Bergmann glia function in granule cell migration during cerebellum development. Molecular Neurobiology, 47, 833-844.
Yamagata, K. (2021). Astrocyte-induced synapse formation and ischemic stroke. Journal of Neuroscience Research, 99, 1401-1413.
Yanyu, X., Yunmei, S., Zhipeng, C., & Qineng, P. (2006). The preparation of silybin-phospholipid complex and the study on its pharmacokinetics in rats. International Journal of Pharmaceutics, 307, 77-82.
Yao, Y. M., & Liu, H. (2005). New understanding of the role of high mobility group protein B1. Chinese Critical Care Medicine, 7, 385-387.
Yin, S., Pang, A., Liu, C., Li, Y., Liu, N., Li, S., Li, C., Sun, H., Fu, Z., Wang, Y., Zhang, Y., Yang, M., Sun, J., Wang, Y., & Yang, X. (2022). Peptide OM-LV20 protects astrocytes against oxidative stress via the ‘PAC1R/JNK/TPH1’ axis. The Journal of Biological Chemistry, 298, 102429.
Ylera, B., Ertürk, A., Hellal, F., Nadrigny, F., Hurtado, A., Tahirovic, S., Oudega, M., Kirchhoff, F., & Bradke, F. (2009). Chronically CNS-injured adult sensory neurons gain regenerative competence upon a lesion of their peripheral axon. Current Biology, 19, 930-936.
Zamanian, J. L., Xu, L., Foo, L. C., Nouri, N., Zhou, L., Giffard, R. G., & Barres, B. A. (2012). Genomic analysis of reactive astrogliosis. The Journal of Neuroscience, 32, 6391-6410.
Zang, C., Liu, H., Shang, J., Yang, H., Wang, L., Sheng, C., Zhang, Z., Bao, X., Yu, Y., Yao, X., & Zhang, D. (2021). Gardenia jasminoides J. Ellis extract GJ-4 alleviated cognitive deficits of APP/PS1 transgenic mice. Phytomedicine, 93, 153780.
Zehnder, T., Petrelli, F., Romanos, J., de Oliveira Figueiredo, E. C., Lewis, T. L. Jr., Déglon, N., Polleux, F., Santello, M., & Bezzi, P. (2021). Mitochondrial biogenesis in developing astrocytes regulates astrocyte maturation and synapse formation. Cell Reports, 35, 108952.
Zeng, L. H., Bero, A. W., Zhang, B., Holtzman, D. M., & Wong, M. (2010). Modulation of astrocyte glutamate transporters decreases seizures in a mouse model of tuberous sclerosis complex. Neurobiology of Disease, 37, 764-771.
Zhai, J., Kim, H., Han, S. B., Manire, M., Yoo, R., Pang, S., Smith, G. M., & Son, Y. J. (2021). Co-targeting myelin inhibitors and CSPGs markedly enhances regeneration of GDNF-stimulated, but not conditioning-lesioned, sensory axons into the spinal cord. eLife, 10, e63050.
Zhang, Z., Liu, H., Zhao, Z., Zang, C., Ju, C., Li, F., Wang, L., Yang, H., Bao, X., Yu, Y., Yao, X., & Zhang, D. (2020). GJ-4 alleviates Aβ(25-35)-induced memory dysfunction in mice through protecting the neurovascular unit. Biomedicine & Pharmacotherapy, 127, 110131. https://doi.org/10.1016/j.biopha.2020.110131
Zhang, Y., Zhu, T., Zhang, X., Chao, J., Hu, G., & Yao, H. (2015). Role of high-mobility group box 1 in methamphetamine-induced activation and migration of astrocytes. Journal of Neuroinflammation, 12, 156.
Zhao, J., Yang, M., & Wu, J. (2021). CXCL16 may be a predisposing factor to atherosclerosis: An animal study. Molecular Medicine Reports, 24, 716.
Zheng, J., Xie, Y., Ren, L., Qi, L., Wu, L., Pan, X., Zhou, J., Chen, Z., & Liu, L. (2021). GLP-1 improves the supportive ability of astrocytes to neurons by promoting aerobic glycolysis in Alzheimer's disease. Molecular Metabolism, 47, 101180.
Zhou, X., Liang, J., Wang, J., Fei, Z., Qin, G., Zhang, D., Zhou, J., & Chen, L. (2020). Up-regulation of astrocyte excitatory amino acid transporter 2 alleviates central sensitization in a rat model of chronic migraine. Journal of Neurochemistry, 155, 370-389. https://doi.org/10.1111/jnc.14944
Zhou, Y., Song, W. M., Andhey, P. S., Swain, A., Levy, T., Miller, K. R., Poliani, P. L., Cominelli, M., Grover, S., Gilfillan, S., Cella, M., Ulland, T. K., Zaitsev, K., Miyashita, A., Ikeuchi, T., Sainouchi, M., Kakita, A., Bennett, D. A., Schneider, J. A., … Colonna, M. (2020). Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular Aresponses in Alzheimer's disease. Nature Medicine, 26, 131-142. https://doi.org/10.1038/s41591-019-0695-9
Zhou, B., Zuo, Y. X., & Jiang, R. T. (2019). Astrocyte morphology: Diversity, plasticity, and role in neurological diseases. CNS Neuroscience & Therapeutics, 25, 665-673.
Zonta, M., Angulo, M. C., Gobbo, S., Rosengarten, B., Hossmann, K. A., Pozzan, T., & Carmignoto, G. (2003). Neuron-to-astrocyte signaling is central to the dynamic control of brain microcirculation. Nature Neuroscience, 6, 43-50.
Zwain, I. H., & Yen, S. S. (1999). Neurosteroidogenesis in astrocytes, oligodendrocytes, and neurons of cerebral cortex of rat brain. Endocrinology, 140, 3843-3852.