Age-related influence on DNA damage, proteomic inflammatory markers and oxidative stress in hospitalized COVID-19 patients compared to healthy controls.
COVID-19
DNA damage
Hospitalized patients
Inflammation
Oxidative stress
Proteomics
SARS-COV-2
Journal
Redox biology
ISSN: 2213-2317
Titre abrégé: Redox Biol
Pays: Netherlands
ID NLM: 101605639
Informations de publication
Date de publication:
11 2023
11 2023
Historique:
received:
06
07
2023
revised:
29
09
2023
accepted:
01
10
2023
medline:
30
10
2023
pubmed:
14
10
2023
entrez:
13
10
2023
Statut:
ppublish
Résumé
COVID-19 infections are accompanied by adverse changes in inflammatory pathways that are also partly influenced by increased oxidative stress and might result in elevated DNA damage. The aim of this case-control study was to examine whether COVID-19 patients show differences in oxidative stress-related markers, unconjugated bilirubin (UCB), an inflammation panel and DNA damage compared to healthy, age-and sex-matched controls. The Comet assay with and without the treatment of formamidopyrimidine DNA glycosylase (FPG) and H
Identifiants
pubmed: 37832397
pii: S2213-2317(23)00315-4
doi: 10.1016/j.redox.2023.102914
pmc: PMC10585323
pii:
doi:
Substances chimiques
DNA-Formamidopyrimidine Glycosylase
EC 3.2.2.23
Hydrogen Peroxide
BBX060AN9V
Bilirubin
RFM9X3LJ49
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
102914Informations de copyright
Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.