Early-life exposure to residential black carbon and childhood cardiometabolic health.
Adiposity
Air pollution
Black carbon
Early childhood
Lipids
Prenatal exposure
Journal
Environmental research
ISSN: 1096-0953
Titre abrégé: Environ Res
Pays: Netherlands
ID NLM: 0147621
Informations de publication
Date de publication:
15 Dec 2023
15 Dec 2023
Historique:
received:
24
03
2023
revised:
08
09
2023
accepted:
30
09
2023
pmc-release:
15
12
2024
medline:
22
11
2023
pubmed:
14
10
2023
entrez:
13
10
2023
Statut:
ppublish
Résumé
Early life exposure to air pollution, such as particulate matter ≤2.5 μm (PM This study included 578 mother-child pairs enrolled in the Healthy Start study (2009-2014) living in the Denver-metro area. Using a spatiotemporal prediction model, we assessed average residential black carbon levels during pregnancy and in the year prior to the early childhood follow-up visit at approximately 5 years old. We estimated associations between prenatal and early childhood BC and indicators of adiposity and cardiometabolic biomarkers in early childhood (mean 4.8 years; range, 4.0, 8.3), using linear regression. We found higher early childhood BC was associated with higher percent fat mass, fat mass index, insulin, and homeostatic model assessment for insulin resistance (HOMA-IR), and lower leptin and waist circumference at approximately 5 years old, after adjusting for covariates. For example, per interquartile range (IQR) increase in early childhood BC (IQR, 0.49 μg/m Higher early childhood, but not in utero, ambient concentrations of black carbon, a component of air pollution, were associated with greater adiposity and altered insulin homeostasis at approximately 5 years old. Future studies should examine whether these changes persist later in life.
Sections du résumé
BACKGROUND
BACKGROUND
Early life exposure to air pollution, such as particulate matter ≤2.5 μm (PM
METHODS
METHODS
This study included 578 mother-child pairs enrolled in the Healthy Start study (2009-2014) living in the Denver-metro area. Using a spatiotemporal prediction model, we assessed average residential black carbon levels during pregnancy and in the year prior to the early childhood follow-up visit at approximately 5 years old. We estimated associations between prenatal and early childhood BC and indicators of adiposity and cardiometabolic biomarkers in early childhood (mean 4.8 years; range, 4.0, 8.3), using linear regression.
RESULTS
RESULTS
We found higher early childhood BC was associated with higher percent fat mass, fat mass index, insulin, and homeostatic model assessment for insulin resistance (HOMA-IR), and lower leptin and waist circumference at approximately 5 years old, after adjusting for covariates. For example, per interquartile range (IQR) increase in early childhood BC (IQR, 0.49 μg/m
CONCLUSIONS
CONCLUSIONS
Higher early childhood, but not in utero, ambient concentrations of black carbon, a component of air pollution, were associated with greater adiposity and altered insulin homeostasis at approximately 5 years old. Future studies should examine whether these changes persist later in life.
Identifiants
pubmed: 37832765
pii: S0013-9351(23)02089-3
doi: 10.1016/j.envres.2023.117285
pmc: PMC10842121
mid: NIHMS1940444
pii:
doi:
Substances chimiques
Air Pollutants
0
Particulate Matter
0
Soot
0
Insulin
0
Carbon
7440-44-0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
117285Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK076648
Pays : United States
Organisme : NIH HHS
ID : UG3 OD023248
Pays : United States
Organisme : NIEHS NIH HHS
ID : F31 ES034938
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002535
Pays : United States
Organisme : NIH HHS
ID : UH3 OD023248
Pays : United States
Organisme : NIEHS NIH HHS
ID : R00 ES025817
Pays : United States
Organisme : NCATS NIH HHS
ID : UM1 TR004399
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001082
Pays : United States
Informations de copyright
Copyright © 2023 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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