Aromatic glycosides and lignans glycosides with their acetylcholinesterase inhibitory activities from the leaves of Picrasma quassioides.
Cholinesterase inhibitory activities
Molecular docking
Picrasma quassioides
Saccharide hydrolysis
Journal
Fitoterapia
ISSN: 1873-6971
Titre abrégé: Fitoterapia
Pays: Netherlands
ID NLM: 16930290R
Informations de publication
Date de publication:
11 Oct 2023
11 Oct 2023
Historique:
received:
14
07
2023
revised:
06
10
2023
accepted:
10
10
2023
medline:
14
10
2023
pubmed:
14
10
2023
entrez:
13
10
2023
Statut:
aheadofprint
Résumé
In this study, eight new natural products were isolated from the leaves of Picrasma quassioides. Spectroscopic techniques were used for the elucidation of their planar structures. Their absolute configurations were elucidated on the basis of electron circular dichroism (ECD) techniques combined with the P/M helicity rule for the 2,3-dihydrobenzofuran chromophore, and saccharide hydrolysis. Cholinesterase inhibitors are often used as Alzheimer's disease inhibitors.Thus, acetylcholinesterase and butyrylcholinesterase inhibitory activity of these eight compounds were tested, and results showed that only compound 6 showed weakly acetylcholinesterase inhibitory activity. In particular, molecular docking was used to illustrate the bindings between compound 6 and the active sites of AChE.
Identifiants
pubmed: 37832877
pii: S0367-326X(23)00276-9
doi: 10.1016/j.fitote.2023.105701
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
105701Informations de copyright
Copyright © 2023. Published by Elsevier B.V.