Co-administration of dl-3-n-butylphthalide and neprilysin is neuroprotective in Alzheimer disease associated with mild traumatic brain injury.

Humans Alzheimer Disease / drug therapy Brain Concussion / complications Amyloid beta-Peptides Neprilysin / therapeutic use Neuroprotection Parkinson Disease / complications Neuroprotective Agents / therapeutic use
Alzheimer’s disease Amyloid beta peptide Blood–brain barrier Brain edema Brain pathology Concussive head injury Neprilysin P-tau dl-3-n-Butylphthalide

Journal

International review of neurobiology
ISSN: 2162-5514
Titre abrégé: Int Rev Neurobiol
Pays: United States
ID NLM: 0374740

Informations de publication

Date de publication:
2023
Historique:
medline: 1 11 2023
pubmed: 14 10 2023
entrez: 13 10 2023
Statut: ppublish

Résumé

dl-3-n-Butylphthalide is a potent synthetic Chinese celery extract that is highly efficient in inducing neuroprotection in concussive head injury (CHI), Parkinson's disease, Alzheimer's disease, stroke as well as depression, dementia, anxiety and other neurological diseases. Thus, there are reasons to believe that dl-3-n-butylphthalide could effectively prevent Alzheimer's disease brain pathology. Military personnel during combat operation or veterans are often the victims of brain injury that is a major risk factor for developing Alzheimer's disease in their later lives. In our laboratory we have shown that CHI exacerbates Alzheimer's disease brain pathology and reduces the amyloid beta peptide (AβP) inactivating enzyme neprilysin. We have used TiO

Identifiants

DOI: 10.1016/bs.irn.2023.06.006 PMID: 37833011
pubmed: 37833011
pii: S0074-7742(23)00054-5
doi: 10.1016/bs.irn.2023.06.006
pii:
doi:

Substances chimiques

Amyloid beta-Peptides 0
Neprilysin EC 3.4.24.11
3-n-butylphthalide 822Q956KGM
Neuroprotective Agents 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

145-185

Subventions

Organisme : NIA NIH HHS
ID : R01 AG028679
Pays : United States

Informations de copyright

Copyright © 2023. Published by Elsevier Inc.

Déclaration de conflit d'intérêts

Conflict of interest There is no conflict of interest between any entity and/or organization mentioned here.

Auteurs

Zhenguo G Wang (ZG)

CSPC NBP Pharmaceutical Medicine, Shijiazhuang, Hebei Province, P.R. China.

Aruna Sharma (A)

International Experimental Central Nervous System Injury & Repair (IECNSIR), Dept. of Surgical Sciences, Anesthesiology & Intensive Care Medicine, Uppsala University Hospital, Uppsala University, Uppsala, Sweden. Electronic address: Aruna.Sharma@surgsci.uu.se.

Lianyuan Feng (L)

Department of Neurology, Bethune International Peace Hospital, Zhongshan Road (West), Shijiazhuang, Hebei Province, P.R. China.

Dafin F Muresanu (DF)

Dept. Clinical Neurosciences, University of Medicine & Pharmacy, Cluj-Napoca, Romania; "RoNeuro'' Institute for Neurological Research and Diagnostic, Mircea Eliade Street, Cluj-Napoca, Romania.

Z Ryan Tian (ZR)

Dept. Chemistry & Biochemistry, University of Arkansas, Fayetteville, AR, United States.

José Vicente Lafuente (JV)

LaNCE, Dept. Neuroscience, University of the Basque Country (UPV/EHU), Leioa, Bizkaia, Spain.

Anca D Buzoianu (AD)

Department of Clinical Pharmacology and Toxicology, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.

Ala Nozari (A)

Department of Anesthesiology, Boston University, Albany str, Boston, MA, USA.

Hongyun Huang (H)

Beijing Hongtianji Neuroscience Academy, Beijing, P.R. China.

Lin Chen (L)

Department of Neurosurgery, Dongzhimen Hospital, Beijing University of Traditional Chinese Medicine, Beijing, P.R. China.

Igor Manzhulo (I)

Laboratory of Pharmacology, National Scientific Center of Marine Biology, Far East Branch of the Russian Academy of Sciences, Vladivostok, Russia.

Lars Wiklund (L)

International Experimental Central Nervous System Injury & Repair (IECNSIR), Dept. of Surgical Sciences, Anesthesiology & Intensive Care Medicine, Uppsala University Hospital, Uppsala University, Uppsala, Sweden.

Hari Shanker Sharma (HS)

International Experimental Central Nervous System Injury & Repair (IECNSIR), Dept. of Surgical Sciences, Anesthesiology & Intensive Care Medicine, Uppsala University Hospital, Uppsala University, Uppsala, Sweden; LaNCE, Dept. Neuroscience, University of the Basque Country (UPV/EHU), Leioa, Bizkaia, Spain. Electronic address: Sharma@surgsci.uu.se.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Co-administration of dl-3-n-butylphthalide and...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › Co-administration of dl-3-n-butylphthalide and...
questionsmedicales.fr › Plaies et blessures › Plaies non pénétrantes › Traumatismes crâniens fermés › Commotion de l'encéphale › Co-administration of dl-3-n-butylphthalide and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Peptides bêta-amyloïdes › Co-administration of dl-3-n-butylphthalide and...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Marqueurs biologiques tumoraux › Néprilysine › Co-administration of dl-3-n-butylphthalide and...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Neuroprotection › Co-administration of dl-3-n-butylphthalide and...
questionsmedicales.fr › Maladies du système nerveux › Maladies neurodégénératives › Maladie de Parkinson › Co-administration of dl-3-n-butylphthalide and...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Neuroprotecteurs › Co-administration of dl-3-n-butylphthalide and...