The effectiveness and safety of non-pharmacological intervention for pain management in Parkinson's disease: A systematic review.

Exercises Non-pharmacological interventions Pain Parkinson's disease Physical activities

Journal

Revue neurologique
ISSN: 0035-3787
Titre abrégé: Rev Neurol (Paris)
Pays: France
ID NLM: 2984779R

Informations de publication

Date de publication:
11 Oct 2023
Historique:
received: 03 02 2023
revised: 19 04 2023
accepted: 23 04 2023
medline: 14 10 2023
pubmed: 14 10 2023
entrez: 13 10 2023
Statut: aheadofprint

Résumé

Chronic pain is a non-motor symptom affecting from 60 to 80% of patients with Parkinson's disease (PD). PD patients can suffer from different types of pain, either specific or not specific of the disease, and depending on various pathophysiological mechanisms (nociceptive, nociplastic or neuropathic), which can be present at any stage of the disease. Non-pharmacological interventions (NPIs) are essential to complement routine care interventions in PD pain management. Moreover, in the literature, it has been shown that 42% of PD patients are already using complementary therapies. Hence, our aim was to investigate the effectiveness and safety of NPIs for pain management in PD. A systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Eighteen published randomized control trials (RCTs) were included between 2004 and 2021 leading to a total of 976 PD patients. From them, we reported fifteen different NPIs classified in seven categories: physical exercises, balneotherapy, manual therapy, acupuncture, botanical preparation, body-psychological practice and multiprotection care. Our results have shown that NPIs for PD pain management had a low-to-moderate level of evidence showing mainly favourable results, even if some NPIs presented inconclusive results. Moreover, our review highlighted the clinical relevance of some specific NPIs in PD pain management: NPIs consisting of active physical activities, opposed to passive activities. The safety of NPIs was also confirmed since only few minor transient adverse events were reported. Nevertheless, even if some interesting results were found, the methodology of future studies needs to be more robust and to include comprehensive descriptions in order to offer reliable and sound recommendations to clinicians.

Identifiants

DOI: 10.1016/j.neurol.2023.04.010 PMID: 37833205
pubmed: 37833205
pii: S0035-3787(23)01041-X
doi: 10.1016/j.neurol.2023.04.010
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2023 Elsevier Masson SAS. All rights reserved.

Auteurs

M Huissoud (M)

Toulouse NeuroImaging Center (ToNIC), University of Toulouse, Inserm UMR1214, University Paul-Sabatier (UPS), Toulouse, France.

M Boussac (M)

Toulouse NeuroImaging Center (ToNIC), University of Toulouse, Inserm UMR1214, University Paul-Sabatier (UPS), Toulouse, France. Electronic address: mathilde.boussac@inserm.fr.

K Joineau (K)

Toulouse NeuroImaging Center (ToNIC), University of Toulouse, Inserm UMR1214, University Paul-Sabatier (UPS), Toulouse, France.

E Harroch (E)

Department of Clinical Pharmacology and Neurosciences, Centre d'Investigation Clinique (CIC1436), NS-Park/FCRIN Network, Toulouse, France.

C Brefel-Courbon (C)

Toulouse NeuroImaging Center (ToNIC), University of Toulouse, Inserm UMR1214, University Paul-Sabatier (UPS), Toulouse, France; Department of Clinical Pharmacology and Neurosciences, Centre d'Investigation Clinique (CIC1436), NS-Park/FCRIN Network, Toulouse, France.

E Descamps (E)

Toulouse NeuroImaging Center (ToNIC), University of Toulouse, Inserm UMR1214, University Paul-Sabatier (UPS), Toulouse, France; CNRS, Toulouse, France.

Classifications MeSH