Bilateral interstitial keratitis following COVID-19: a case report.
COVID-19
Interstitial keratitis
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Journal
BMC ophthalmology
ISSN: 1471-2415
Titre abrégé: BMC Ophthalmol
Pays: England
ID NLM: 100967802
Informations de publication
Date de publication:
13 Oct 2023
13 Oct 2023
Historique:
received:
19
03
2023
accepted:
02
10
2023
medline:
1
11
2023
pubmed:
14
10
2023
entrez:
13
10
2023
Statut:
epublish
Résumé
Although the primary target of severe acute respiratory syndrome coronavirus 2 is the respiratory tract, the expression of the angiotensin-converting enzyme 2 receptor in other tissues facilitates viral entry in others parts of the body, including ocular structures. Ocular manifestations may occur before, during, or after systemic infection. We report the case of a 60-year-old male who presented with bilateral interstitial keratitis after the onset of COVID-19, with ocular symptoms starting within 7 days after systemic symptoms. Laboratory investigation did not identify any alternative etiology for his disease, although the possibility of Epstein-Barr virus or herpes simpex virus could not be definitively ruled out. The patient had already developed significant corneal scarring and visual debilitation by the time topical steroids were initiated, and his final corrected visual acuity with rigid gas permeable contact lenses was 20/50 and 20/80 in the right and left eye, respectively. The involvement of ocular tissue by the virus can lead to permanent sequelae such as severe visual loss, and clinicians should be aware of and recognize ophthalmic manifestations of this disease to prompt early intervention.
Sections du résumé
BACKGROUND
BACKGROUND
Although the primary target of severe acute respiratory syndrome coronavirus 2 is the respiratory tract, the expression of the angiotensin-converting enzyme 2 receptor in other tissues facilitates viral entry in others parts of the body, including ocular structures. Ocular manifestations may occur before, during, or after systemic infection.
CASE PRESENTATION
METHODS
We report the case of a 60-year-old male who presented with bilateral interstitial keratitis after the onset of COVID-19, with ocular symptoms starting within 7 days after systemic symptoms. Laboratory investigation did not identify any alternative etiology for his disease, although the possibility of Epstein-Barr virus or herpes simpex virus could not be definitively ruled out. The patient had already developed significant corneal scarring and visual debilitation by the time topical steroids were initiated, and his final corrected visual acuity with rigid gas permeable contact lenses was 20/50 and 20/80 in the right and left eye, respectively.
CONCLUSIONS
CONCLUSIONS
The involvement of ocular tissue by the virus can lead to permanent sequelae such as severe visual loss, and clinicians should be aware of and recognize ophthalmic manifestations of this disease to prompt early intervention.
Identifiants
pubmed: 37833623
doi: 10.1186/s12886-023-03160-4
pii: 10.1186/s12886-023-03160-4
pmc: PMC10571384
doi:
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
414Informations de copyright
© 2023. BioMed Central Ltd., part of Springer Nature.
Références
Lancet. 2020 May 23;395(10237):1610
pubmed: 32405105
Ocul Surf. 2019 Jan;17(1):40-49
pubmed: 30317007
J Fr Ophtalmol. 2019 Jun;42(6):e229-e237
pubmed: 31103357
Cornea. 1998 May;17(3):278-81
pubmed: 9603383
Cornea. 2021 Jan;40(1):123-124
pubmed: 32889957
Neurology. 2020 Sep 1;95(9):411
pubmed: 32868480
J Pathol. 2021 Jul;254(4):307-331
pubmed: 33586189
Ocul Surf. 2021 Jan;19:190-200
pubmed: 32502616
BMJ Open Ophthalmol. 2020 Sep 06;5(1):e000563
pubmed: 34192152
Ocul Surf. 2020 Oct;18(4):537-544
pubmed: 32544566
N Engl J Med. 2020 Jun 25;382(26):2574-2576
pubmed: 32302082
J Stroke Cerebrovasc Dis. 2020 Aug;29(8):104982
pubmed: 32689586
Orbit. 2022 Jun;41(3):374-377
pubmed: 33402004
Open Forum Infect Dis. 2020 Jun 21;7(7):ofaa249
pubmed: 32661498
Can J Ophthalmol. 2020 Aug;55(4):e125-e129
pubmed: 32284146
BMC Infect Dis. 2023 Apr 26;23(1):259
pubmed: 37101275
Acta Ophthalmol. 2020 Dec;98(8):e1056-e1057
pubmed: 32483943
Clin Exp Optom. 2020 Jul;103(4):418-424
pubmed: 32406140
Curr Opin Ophthalmol. 2020 Nov;31(6):489-494
pubmed: 33009081
J Ophthalmic Vis Res. 2021 Jan 20;16(1):103-112
pubmed: 33520133
J Fr Ophtalmol. 2022 Apr;45(4):e175-e177
pubmed: 35033376
Neurology. 2020 Aug 4;95(5):e601-e605
pubmed: 32303650
Indian J Ophthalmol. 2020 Oct;68(10):2291-2293
pubmed: 32971697
Am J Ophthalmol Case Rep. 2021 Jul 22;23:101175
pubmed: 34368498