Cytokines in Systemic Lupus Erythematosus-Focus on TNF-α and IL-17.
IL-17
TNF-α
cytokines
disease activity
systemic lupus erythematosus
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
22 Sep 2023
22 Sep 2023
Historique:
received:
16
08
2023
revised:
07
09
2023
accepted:
20
09
2023
medline:
23
10
2023
pubmed:
14
10
2023
entrez:
14
10
2023
Statut:
epublish
Résumé
Systemic lupus erythematosus (SLE) is an autoimmune disorder known for its complex pathogenesis, in which cytokines play an essential role. It seems that the modulation of these cytokines may impact disease progression, being considered potential biomarkers. Thus, TNF (tumor necrosis factor)-α and IL (interleukin)-17 are molecules of great interest in SLE. TNF-α plays a dual role in SLE, with both immunosuppressive and proinflammatory functions. The role of IL-17 is clearly described in the pathogenesis of SLE, having a close association with IL-23 in stimulating the inflammatory response and consecutive tissue destruction. It appears that patients with elevated levels of these cytokines are associated with high disease activity expressed by the SLE disease activity index (SLEDAI) score, although some studies do not confirm this association. However, TNF-α and IL-17 are found in increased titers in lupus patients compared to the general population. Whether inhibition of these cytokines would lead to effective treatment is under discussion. In the case of anti-TNF-α therapies in SLE, the possibility of ATIL (anti-TNF-induced lupus) is a serious concern that limits their use. The use of anti-IL-17 therapies in SLE is a promising option, but not yet approved. Future studies of these cytokines in large cohorts will provide valuable information for the management of SLE.
Identifiants
pubmed: 37833861
pii: ijms241914413
doi: 10.3390/ijms241914413
pmc: PMC10572174
pii:
doi:
Substances chimiques
Cytokines
0
Tumor Necrosis Factor-alpha
0
Interleukin-17
0
Tumor Necrosis Factor Inhibitors
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Références
Genes Immun. 2000 Feb;1(3):225-7
pubmed: 11196716
J Rheumatol. 2010 Oct;37(10):2046-52
pubmed: 20682672
J Interferon Cytokine Res. 2019 Jul;39(7):410-415
pubmed: 31173544
Clin Rheumatol. 2016 Jan;35(1):1-18
pubmed: 26573205
Ann Rheum Dis. 2013 Feb;72(2):286-92
pubmed: 22904262
J Immunol Res. 2017;2017:5096741
pubmed: 28286780
Clin Rheumatol. 2007 Sep;26(9):1481-9
pubmed: 17235653
Clin Exp Immunol. 2012 Aug;169(2):89-99
pubmed: 22774983
Autoimmunity. 2015;48(6):353-61
pubmed: 25894789
Arthritis Res Ther. 2013 Aug 23;15(4):R97
pubmed: 23968496
Biomed Res Int. 2021 Jul 21;2021:9952463
pubmed: 34337065
Arthritis Rheum. 2009 Jun;60(6):1647-56
pubmed: 19479869
Ann Rheum Dis. 2006 Apr;65(4):545-8
pubmed: 16096331
Eur J Biochem. 1991 Nov 15;202(1):3-14
pubmed: 1657606
Nature. 1988 Jan 28;331(6154):356-8
pubmed: 2893286
Nat Rev Immunol. 2008 May;8(5):337-48
pubmed: 18408735
Cytokine. 2015 Apr;72(2):146-53
pubmed: 25647269
Curr Allergy Asthma Rep. 2012 Feb;12(1):1-7
pubmed: 22086298
Cell Death Differ. 2003 Jan;10(1):45-65
pubmed: 12655295
Cytokine. 2006 Aug;35(3-4):148-53
pubmed: 17027280
Clin Immunol. 2008 Jun;127(3):385-93
pubmed: 18373953
Cold Spring Harb Perspect Biol. 2018 Apr 2;10(4):
pubmed: 28620097
Lupus. 2010 May;19(6):689-95
pubmed: 20179168
J Immunol. 2008 Dec 15;181(12):8391-401
pubmed: 19050256
Nat Rev Rheumatol. 2022 May;18(5):286-300
pubmed: 35393604
Lupus. 2020 Jan;29(1):6-14
pubmed: 31791181
Clin Exp Immunol. 2010 Jan;159(1):1-10
pubmed: 19807734
Rheumatol Int. 2012 Apr;32(4):949-58
pubmed: 21243492
Lupus. 2021 Mar;30(3):459-464
pubmed: 33183127
J Clin Invest. 2006 May;116(5):1310-6
pubmed: 16670770
Nat Rev Drug Discov. 2010 Jun;9(6):482-93
pubmed: 20489699
Arthritis Rheum. 2004 Oct;50(10):3161-9
pubmed: 15476222
J Biomed Biotechnol. 2010;2010:365083
pubmed: 20467470
Int J Rheum Dis. 2019 Aug;22(8):1419-1426
pubmed: 31179646
Nephrology (Carlton). 2010 Aug;15(5):513-21
pubmed: 20649870
Br J Rheumatol. 1996 Nov;35(11):1067-74
pubmed: 8948291
Curr Dir Autoimmun. 2010;11:105-18
pubmed: 20173390
Lupus. 2003;12(6):454-61
pubmed: 12873047
Acad Emerg Med. 2000 Aug;7(8):930-41
pubmed: 10958139
Nat Immunol. 2008 Feb;9(2):166-75
pubmed: 18157131
Arthritis Res Ther. 2008;10(1):202
pubmed: 18226185
Cytokine Growth Factor Rev. 2013 Feb;24(1):51-7
pubmed: 22906768
J Cell Immunol. 2019;1(2):33-42
pubmed: 31984378
Semin Arthritis Rheum. 2004 Jun;33(6):404-13
pubmed: 15190525
Am J Pathol. 2008 Jan;172(1):146-55
pubmed: 18156204
Immunity. 2009 Nov 20;31(5):799-810
pubmed: 19853481
Malays J Pathol. 2020 Dec;42(3):333-347
pubmed: 33361714
Arthritis Res Ther. 2003;5(4):172-7
pubmed: 12823847
Cell Immunol. 2010;264(1):97-103
pubmed: 20553755
Arthritis Rheum. 2000 Nov;43(11):2455-63
pubmed: 11083268
Adv Immunol. 2006;92:1-69
pubmed: 17145301
Arthritis Res Ther. 2010;12(4):R150
pubmed: 20653937
Arthritis Rheum. 2009 May;60(5):1472-83
pubmed: 19404966
J Clin Immunol. 2010 Mar;30(2):221-5
pubmed: 20107878
Arthritis Rheum. 2001 Sep;44(9):2097-106
pubmed: 11592372
Arthritis Res. 2002;4 Suppl 3:S197-211
pubmed: 12110140
Int J Mol Sci. 2022 Apr 30;23(9):
pubmed: 35563387
J Neurochem. 2006 Jul;98(1):203-12
pubmed: 16638016
Clin Med (Lond). 2001 Jan-Feb;1(1):10-4
pubmed: 11358068
ScientificWorldJournal. 2007 Oct 22;7:1715-35
pubmed: 17982568
RMD Open. 2017 Dec 29;3(2):e000555
pubmed: 29435362
J Clin Invest. 1999 May;103(9):1345-52
pubmed: 10225978
Ann Transl Med. 2021 Mar;9(5):430
pubmed: 33842651
J Rheumatol. 2005 Apr;32(4):740-3
pubmed: 15801034
Science. 2004 Mar 5;303(5663):1532-5
pubmed: 15001782
Rheumatology (Oxford). 2010 Jul;49(7):1215-28
pubmed: 20194223
J Immunol. 2006 Jul 1;177(1):566-73
pubmed: 16785554
Rheumatology (Oxford). 2009 Dec;48(12):1491-7
pubmed: 19773408
BioDrugs. 2014 Dec;28(6):487-97
pubmed: 24890029
Am J Transl Res. 2021 Apr 15;13(4):2867-2874
pubmed: 34017450
Am J Pathol. 2009 Sep;175(3):1167-77
pubmed: 19700754
Egypt J Immunol. 2012;19(2):25-33
pubmed: 23885404
Gut. 2003 Jan;52(1):65-70
pubmed: 12477762
Rheumatology (Oxford). 2014 Sep;53(9):1586-94
pubmed: 24706988
Eur J Intern Med. 2010 Jun;21(3):202-7
pubmed: 20493423
Eur J Immunol. 2000 Jul;30(7):2038-47
pubmed: 10940893
Lupus. 2017 Aug;26(9):917-926
pubmed: 27927883
Discov Med. 2018 Jan;25(135):14-20
pubmed: 29466690
J Immunol. 2009 Sep 1;183(5):3160-9
pubmed: 19657089
Arthritis Rheum. 2003 Sep;48(9):2533-40
pubmed: 13130473
Int J Rheum Dis. 2020 Apr;23(4):465-471
pubmed: 32134201
Cytokine. 2015 Dec;76(2):280-287
pubmed: 26073684
J Am Acad Dermatol. 2006 Mar;54(3 Suppl 2):S139-42
pubmed: 16488329
PLoS One. 2012;7(4):e31000
pubmed: 22485125
J Exp Med. 2007 Dec 24;204(13):3183-94
pubmed: 18039949
Eur J Hum Genet. 2006 Jan;14(1):69-78
pubmed: 16306881
J Immunol. 2007 Feb 1;178(3):1960-6
pubmed: 17237447
Lupus. 2006;15(12):881-5
pubmed: 17211995
Arch Immunol Ther Exp (Warsz). 2015 Dec;63(6):435-49
pubmed: 26062902
J Immunol. 2001 May 1;166(9):5495-507
pubmed: 11313388
Rheumatol Int. 2007 May;27(7):621-30
pubmed: 17103171
Lupus. 2002;11(12):850-5
pubmed: 12529050
Immunity. 2009 Apr 17;30(4):576-87
pubmed: 19362022
Nephrol Dial Transplant. 2005 Jul;20(7):1400-6
pubmed: 15840673
PLoS One. 2009 Jun 17;4(6):e5903
pubmed: 19536281
JGH Open. 2019 Dec 19;4(3):507-510
pubmed: 32514462
Clin Immunol Immunopathol. 1989 Sep;52(3):421-34
pubmed: 2758698
Expert Opin Biol Ther. 2021 May;21(5):639-647
pubmed: 33216641
Clin Biochem. 2005 Feb;38(2):134-41
pubmed: 15642275
Sci Rep. 2016 Feb 05;6:20651
pubmed: 26847824
Cytokine. 2011 Dec;56(3):537-43
pubmed: 21907587
J Investig Med. 2014 Jun;62(5):825-9
pubmed: 24987977
Arthritis Res Ther. 2014 Jan 07;16(1):R4
pubmed: 24398084
Rheumatology (Oxford). 2009 Nov;48(11):1451-4
pubmed: 19748965
Best Pract Res Clin Rheumatol. 2017 Jun;31(3):306-320
pubmed: 29224673
Clin Rheumatol. 1999;18(1):17-22
pubmed: 10088943
Semin Immunol. 2007 Dec;19(6):394-9
pubmed: 18221887
Immunol Ser. 1992;56:3-34
pubmed: 1550865
Arthritis Rheum. 2012 Sep;64(9):2947-52
pubmed: 22488302
Lupus. 2012 Sep;21(10):1105-12
pubmed: 22759859
J Immunol. 2008 Aug 15;181(4):2898-906
pubmed: 18684981
Lupus. 2000;9(8):589-93
pubmed: 11035433
Adv Physiol Educ. 2013 Dec;37(4):284-91
pubmed: 24292903
Lupus Sci Med. 2018 Jun 04;5(1):e000260
pubmed: 29955370
Tissue Antigens. 1999 Jun;53(6):527-33
pubmed: 10395102
Sci Rep. 2019 Aug 13;9(1):11752
pubmed: 31409832
J Immunol. 1989 Jul 1;143(1):103-12
pubmed: 2525144
Int J Mol Sci. 2020 Sep 26;21(19):
pubmed: 32993066
Int J Mol Med. 2022 Apr;49(4):
pubmed: 35137914
Eur J Rheumatol. 2017 Mar;4(1):29-35
pubmed: 28293450
Nephrol Dial Transplant. 2009 Jul;24(7):2144-50
pubmed: 19202167
Clin Exp Immunol. 2018 Jan;191(1):1-10
pubmed: 28836661
J Immunol. 2008 Dec 15;181(12):8761-6
pubmed: 19050297
Eur J Immunol. 2007 Nov;37 Suppl 1:S34-45
pubmed: 17972343
Diagnostics (Basel). 2022 Jun 20;12(6):
pubmed: 35741309