Inhibition of Factor XI: A New Era in the Treatment of Venous Thromboembolism in Cancer Patients?
FXI inhibitors
cancer-associated thrombosis
catheter-related thrombosis
venous thromboembolism
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
22 Sep 2023
22 Sep 2023
Historique:
received:
06
08
2023
revised:
03
09
2023
accepted:
13
09
2023
medline:
1
11
2023
pubmed:
14
10
2023
entrez:
14
10
2023
Statut:
epublish
Résumé
Direct oral anticoagulants against activated factor X and thrombin were the last milestone in thrombosis treatment. Step by step, they replaced antivitamin K and heparins in most of their therapeutic indications. As effective as the previous anticoagulant, the decreased but persistent risk of bleeding while using direct oral anticoagulants has created space for new therapeutics aiming to provide the same efficacy with better safety. On this basis, drug targeting factor XI emerged as an option. In particular, cancer patients might be one of the populations that will most benefit from this technical advance. In this review, after a brief presentation of the different factor IX inhibitors, we explore the potential benefit of this new treatment for cancer patients.
Identifiants
pubmed: 37833881
pii: ijms241914433
doi: 10.3390/ijms241914433
pmc: PMC10572808
pii:
doi:
Substances chimiques
Factor XI
9013-55-2
Anticoagulants
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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