Nicotine: From Discovery to Biological Effects.
cardiovascular diseases
cell proliferation
cognition
dependence
lung cancer
neo-angiogenesis
nicotine
nicotinic receptor
tobacco
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
26 Sep 2023
26 Sep 2023
Historique:
received:
08
08
2023
revised:
21
09
2023
accepted:
23
09
2023
medline:
1
11
2023
pubmed:
14
10
2023
entrez:
14
10
2023
Statut:
epublish
Résumé
Nicotine, the primary psychoactive agent in tobacco leaves, has led to the widespread use of tobacco, with over one billion smokers globally. This article provides a historical overview of tobacco and discusses tobacco dependence, as well as the biological effects induced by nicotine on mammalian cells. Nicotine induces various biological effects, such as neoangiogenesis, cell division, and proliferation, and it affects neural and non-neural cells through specific pathways downstream of nicotinic receptors (nAChRs). Specific effects mediated by α7 nAChRs are highlighted. Nicotine is highly addictive and hazardous. Public health initiatives should prioritize combating smoking and its associated risks. Understanding nicotine's complex biological effects is essential for comprehensive research and informed health policies. While potential links between nicotine and COVID-19 severity warrant further investigation, smoking remains a significant cause of morbidity and mortality globally. Effective public health strategies are vital to promote healthier lifestyles.
Identifiants
pubmed: 37834017
pii: ijms241914570
doi: 10.3390/ijms241914570
pmc: PMC10572882
pii:
doi:
Substances chimiques
Nicotine
6M3C89ZY6R
Receptors, Nicotinic
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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