Molecular Mechanism of STIL Coiled-Coil Domain Oligomerization.

Biophysical Phenomena Circular Dichroism Dimerization Peptides / chemistry Protein Domains Proteins Humans Intracellular Signaling Peptides and Proteins / chemistry
STIL coiled coil domains oligomerization peptides protein interactions

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
27 Sep 2023
Historique:
received: 20 08 2023
revised: 16 09 2023
accepted: 21 09 2023
medline: 2 11 2023
pubmed: 14 10 2023
entrez: 14 10 2023
Statut: epublish

Résumé

Coiled-coil domains (CCDs) play key roles in regulating both healthy cellular processes and the pathogenesis of various diseases by controlling protein self-association and protein-protein interactions. Here, we probe the mechanism of oligomerization of a peptide representing the CCD of the STIL protein, a tetrameric multi-domain protein that is over-expressed in several cancers and associated with metastatic spread. STIL tetramerization is mediated both by an intrinsically disordered domain (STIL

Identifiants

DOI: 10.3390/ijms241914616 PMID: 37834064 PMC: PMC10572602
pubmed: 37834064
pii: ijms241914616
doi: 10.3390/ijms241914616
pmc: PMC10572602
pii:
doi:

Substances chimiques

Peptides 0
Proteins 0
STIL protein, human 0
Intracellular Signaling Peptides and Proteins 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

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Auteurs

Mai Shamir (M)

Institute of Chemistry, The Hebrew University of Jerusalem, Safra Campus Givat Ram, Jerusalem 91904, Israel.

Freddie J O Martin (FJO)

School of Chemistry, University of Bristol, Cantock's Close, Bristol BS8 1TS, UK.

Derek N Woolfson (DN)

School of Chemistry, University of Bristol, Cantock's Close, Bristol BS8 1TS, UK.
School of Biochemistry, University of Bristol, Biomedical Sciences Building, University Walk, Bristol BS8 1TD, UK.
Bristol BioDesign Institute, University of Bristol, Cantock's Close, Bristol BS8 1TS, UK.
ORCID: 0000-0002-0394-3202

Assaf Friedler (A)

Institute of Chemistry, The Hebrew University of Jerusalem, Safra Campus Givat Ram, Jerusalem 91904, Israel.
ORCID: 0000-0003-1592-1278

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiques › Phénomènes biophysiques › Molecular Mechanism of STIL Coiled-Coil Domain...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Dichroïsme circulaire › Molecular Mechanism of STIL Coiled-Coil Domain...
questionsmedicales.fr › Métabolisme › Dimérisation › Molecular Mechanism of STIL Coiled-Coil Domain...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Molecular Mechanism of STIL Coiled-Coil Domain...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Structure tertiaire des protéines › Domaines protéiques › Molecular Mechanism of STIL Coiled-Coil Domain...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Molecular Mechanism of STIL Coiled-Coil Domain...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Molecular Mechanism of STIL Coiled-Coil Domain...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Molecular Mechanism of STIL Coiled-Coil Domain...