The Role of Adipokines in the Pathologies of the Central Nervous System.
Alzheimer’s disease
adipokines
adipose tissue
depression
encephalitis
meningitis
multiple sclerosis
neurological dysfunctions
protein hormones
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
28 Sep 2023
28 Sep 2023
Historique:
received:
31
08
2023
revised:
24
09
2023
accepted:
27
09
2023
medline:
23
10
2023
pubmed:
14
10
2023
entrez:
14
10
2023
Statut:
epublish
Résumé
Adipokines are protein hormones secreted by adipose tissue in response to disruptions in physiological homeostasis within the body's systems. The regulatory functions of adipokines within the central nervous system (CNS) are multifaceted and intricate, and they have been identified in a number of pathologies. Therefore, specific adipokines have the potential to be used as biomarkers for screening purposes in neurological dysfunctions. The systematic review presented herein focuses on the analysis of the functions of various adipokines in the pathogenesis of CNS diseases. Thirteen proteins were selected for analysis through scientific databases. It was found that these proteins can be identified within the cerebrospinal fluid either by their ability to modify their molecular complex and cross the blood-brain barrier or by being endogenously produced within the CNS itself. As a result, this can correlate with their measurability during pathological processes, including Alzheimer's disease, amyotrophic lateral sclerosis, multiple sclerosis, depression, or brain tumors.
Identifiants
pubmed: 37834128
pii: ijms241914684
doi: 10.3390/ijms241914684
pmc: PMC10572192
pii:
doi:
Substances chimiques
Adipokines
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Références
Cytokine. 2018 Nov;111:518-522
pubmed: 29880272
Prog Mol Biol Transl Sci. 2016;138:85-114
pubmed: 26940388
Physiol Behav. 2003 Oct;80(1):123-34
pubmed: 14568317
Best Pract Res Clin Endocrinol Metab. 2014 Jan;28(1):119-30
pubmed: 24417951
Biol Pharm Bull. 2021;44(10):1548-1550
pubmed: 34602564
Int J Neuropsychopharmacol. 2017 Jun 1;20(6):476-484
pubmed: 28158790
J Acquir Immune Defic Syndr. 2017 Mar 1;74(3):243-249
pubmed: 27861242
J Dermatol. 2015 May;42(5):461-6
pubmed: 25766303
J Neuroinflammation. 2019 Dec 2;16(1):247
pubmed: 31791369
Rev Endocr Metab Disord. 2014 Jun;15(2):157-67
pubmed: 24019064
Postepy Dermatol Alergol. 2018 Oct;35(5):485-489
pubmed: 30429706
Clin Endocrinol (Oxf). 2016 Jun;84(6):932-8
pubmed: 26572532
CNS Neurosci Ther. 2016 Jun;22(6):431-9
pubmed: 27018006
Mediators Inflamm. 2017;2017:5468023
pubmed: 28490838
Alzheimers Dement. 2023 Jan;19(1):9-24
pubmed: 35234337
J Chem Neuroanat. 2020 Dec;110:101855
pubmed: 33031915
Neural Plast. 2018 Jul 29;2018:4593530
pubmed: 30150999
Diabetes Metab Syndr Obes. 2021 Feb 25;14:857-863
pubmed: 33658820
Mol Metab. 2018 Feb;8:13-22
pubmed: 29254602
J Clin Endocrinol Metab. 2009 Aug;94(8):3085-8
pubmed: 19470637
J Clin Endocrinol Metab. 1993 Nov;77(5):1113-9
pubmed: 7521338
PLoS One. 2011 Jan 20;6(1):e15981
pubmed: 21283791
Lipids Health Dis. 2022 Mar 2;21(1):27
pubmed: 35236351
Arch Med Res. 2021 Jul;52(5):544-553
pubmed: 33632629
Int J Mol Sci. 2015 May 18;16(5):11439-51
pubmed: 25993304
Mol Neurobiol. 2019 Apr;56(4):3024-3037
pubmed: 30076527
J Clin Invest. 2003 Jan;111(2):241-50
pubmed: 12531880
Ann Rheum Dis. 2006 Sep;65(9):1198-201
pubmed: 16414972
Clin Chim Acta. 2020 Jun;505:167-171
pubmed: 32145276
Int J Mol Sci. 2019 Nov 11;20(22):
pubmed: 31718027
Int J Mol Sci. 2017 Mar 09;18(3):
pubmed: 28282917
Metabolism. 2011 Apr;60(4):486-90
pubmed: 20488498
J Chem Neuroanat. 2021 Apr;113:101924
pubmed: 33567298
Mol Med Rep. 2015 Mar;11(3):1859-64
pubmed: 25394413
Brain Pathol. 2006 Jan;16(1):60-70
pubmed: 16612983
J Lipid Res. 2022 Oct;63(10):100269
pubmed: 36030928
Clin Psychopharmacol Neurosci. 2020 Feb 29;18(1):109-115
pubmed: 31958911
Signal Transduct Target Ther. 2020 Sep 14;5(1):201
pubmed: 32929074
Am J Physiol Heart Circ Physiol. 2014 Jun 15;306(12):H1714-9
pubmed: 24727494
Pharmacol Res. 2021 May;167:105414
pubmed: 33524540
Saudi Med J. 2019 Jan;40(1):26-32
pubmed: 30617377
J Biol Chem. 2009 Jan 9;284(2):751-8
pubmed: 19010784
Clin Chim Acta. 2003 Mar;329(1-2):53-60
pubmed: 12589965
Signal Transduct Target Ther. 2022 Oct 8;7(1):358
pubmed: 36209270
J Biol Chem. 2011 Nov 11;286(45):39520-7
pubmed: 21930706
Am J Physiol Endocrinol Metab. 2015 Apr 15;308(8):E688-98
pubmed: 25714673
Brain. 2015 Apr;138(Pt 4):918-31
pubmed: 25688078
Cancer Lett. 2021 Mar 1;500:132-146
pubmed: 33309859
Pharmacol Biochem Behav. 2003 Jul;75(4):869-79
pubmed: 12957230
Neuropeptides. 2021 Jun;87:102131
pubmed: 33640616
J Neurochem. 2020 May;153(3):413-425
pubmed: 31603990
Mult Scler. 2021 Oct;27(12):1948-1959
pubmed: 33522403
Mol Cell Endocrinol. 2023 Aug 20;574:111990
pubmed: 37321286
Br J Dermatol. 2008 Aug;159(2):342-50
pubmed: 18547319
PLoS One. 2014 Jun 06;9(6):e98641
pubmed: 24905466
Acta Med Okayama. 2020 Aug;74(4):365-370
pubmed: 32843769
J Sex Med. 2021 May;18(5):875-888
pubmed: 33863684
CNS Neurosci Ther. 2013 Dec;19(12):969-77
pubmed: 24164711
Clin J Am Soc Nephrol. 2015 Sep 4;10(9):1504-6
pubmed: 26286926
Inflamm Res. 2006 Jun;55(6):221-7
pubmed: 16955240
Mol Neurobiol. 2021 Jun;58(6):2663-2670
pubmed: 33486671
J Neuroimmune Pharmacol. 2016 Jun;11(2):332-47
pubmed: 27059917
Sci Rep. 2017 Sep 29;7(1):12435
pubmed: 28963462
Nat Rev Immunol. 2004 May;4(5):371-9
pubmed: 15122202
Immunol Lett. 2021 May;233:92-96
pubmed: 33652029
J Immunol Methods. 2010 Aug 31;360(1-2):84-8
pubmed: 20598708
Am J Pathol. 2008 Jul;173(1):130-43
pubmed: 18556781
Endocr Rev. 2002 Dec;23(6):824-54
pubmed: 12466191
Psychoneuroendocrinology. 1997 Feb;22(2):65-78
pubmed: 9149329
Cell Rep. 2020 Oct 6;33(1):108236
pubmed: 33027652
J Rheumatol. 2002 Jul;29(7):1459-66
pubmed: 12136906
Int J Mol Sci. 2020 Apr 20;21(8):
pubmed: 32325994
Int J Prev Med. 2020 Sep 03;11:136
pubmed: 33088464
Mol Neurobiol. 2017 Sep;54(7):4908-4920
pubmed: 27514756
Int J Mol Sci. 2021 Oct 07;22(19):
pubmed: 34639186
Neurobiol Aging. 2008 Jun;29(6):902-12
pubmed: 17324488
J Neuroinflammation. 2019 Nov 16;16(1):226
pubmed: 31733653
Biochem Biophys Res Commun. 2021 Jan 1;534:707-713
pubmed: 33261886
Biomed Pharmacother. 2018 Feb;98:424-432
pubmed: 29278852
Sci Rep. 2019 Feb 13;9(1):1959
pubmed: 30760755
J Neuropathol Exp Neurol. 2008 May;67(5):388-401
pubmed: 18431257
Crit Care. 2010;14(5):R190
pubmed: 21029428
Int J Dermatol. 2019 Sep;58(9):993-996
pubmed: 31231798
Science. 2004 Apr 2;304(5667):110-5
pubmed: 15064421
Front Endocrinol (Lausanne). 2018 Aug 30;9:499
pubmed: 30214426
Diabetes. 2006 Sep;55(9):2562-70
pubmed: 16936205
Neuropeptides. 2015 Feb;49:63-8
pubmed: 25617953
Neurotherapeutics. 2020 Jan;17(1):252-268
pubmed: 31728850
Diabetes Res Clin Pract. 2015 Oct;110(1):44-50
pubmed: 26293449
Science. 1998 Sep 11;281(5383):1683-6
pubmed: 9733517
Cell Death Dis. 2015 Aug 06;6:e1844
pubmed: 26247729
J Biol Chem. 2003 Oct 10;278(41):40352-63
pubmed: 12878598
Exp Gerontol. 2020 Dec;142:111138
pubmed: 33122129
EBioMedicine. 2018 Feb;28:251-260
pubmed: 29396296
Brain Res. 2019 Feb 1;1704:174-186
pubmed: 30347220
J Immunol. 2009 Nov 15;183(10):6717-23
pubmed: 19864606
Sci Rep. 2019 Feb 27;9(1):2884
pubmed: 30814586
J Neurol Sci. 1997 Oct 22;151(2):185-8
pubmed: 9349674
Hepatology. 2008 Aug;48(2):374-84
pubmed: 18666256
Diabetes. 2021 Oct;70(10):2264-2274
pubmed: 34344788
Med Oncol. 2014 May;31(5):921
pubmed: 24668415
Protein Cell. 2015 Apr;6(4):254-64
pubmed: 25682154
Neurol Neuroimmunol Neuroinflamm. 2020 Dec 8;8(1):
pubmed: 33293459
CNS Neurosci Ther. 2014 Jun;20(6):539-47
pubmed: 24750959
J Clin Endocrinol Metab. 2010 Jun;95(6):2892-6
pubmed: 20375212
Trends Endocrinol Metab. 2010 Nov;21(11):660-7
pubmed: 20817486
Growth Horm IGF Res. 2017 Apr;33:1-8
pubmed: 27919008
Int Immunopharmacol. 2006 Dec 20;6(13-14):1935-42
pubmed: 17161346
Int J Mol Sci. 2017 Dec 28;19(1):
pubmed: 29283409
Prague Med Rep. 2015;116(2):87-111
pubmed: 26093665
Circulation. 2003 Aug 12;108(6):736-40
pubmed: 12874180
Int J Mol Sci. 2021 Feb 22;22(4):
pubmed: 33671547
Biomark Insights. 2007 May 03;2:128-46
pubmed: 19662198
Neuron. 2010 Sep 9;67(5):834-46
pubmed: 20826314
Curr Med Chem. 2008;15(18):1851-62
pubmed: 18691043
Clin Chim Acta. 2021 Jan;512:84-91
pubmed: 33248946
Horm Mol Biol Clin Investig. 2016 Apr 1;26(1):25-42
pubmed: 26910750
Ticks Tick Borne Dis. 2022 Mar;13(2):101895
pubmed: 35042079
Tsitol Genet. 2010 Jan-Feb;44(1):3-9
pubmed: 20201406
Ann Clin Transl Neurol. 2017 Jul 11;4(8):591-600
pubmed: 28812049
World Neurosurg. 2020 Feb;134:e120-e143
pubmed: 31606503
Endocr Rev. 1995 Feb;16(1):3-34
pubmed: 7758431
Brain Behav Immun. 2013 Nov;34:98-107
pubmed: 23916894
PLoS One. 2011;6(8):e23968
pubmed: 21887354
Nature. 2006 Sep 21;443(7109):289-95
pubmed: 16988703
Clin Chim Acta. 2021 May;516:64-68
pubmed: 33508251
Brain Behav. 2020 Jul;10(7):e01678
pubmed: 32478488
Pflugers Arch. 2020 Jun;472(6):673-681
pubmed: 32462328
Diabetes. 2009 Dec;58(12):2731-40
pubmed: 19720798
Peptides. 2012 Nov;38(1):8-12
pubmed: 22960047
Growth Horm IGF Res. 2013 Jun;23(3):53-61
pubmed: 23583027
Mol Biol Rep. 2009 Apr;36(4):677-82
pubmed: 18373213
Adv Clin Chem. 2014;65:91-142
pubmed: 25233612
Dig Liver Dis. 2020 May;52(5):573-581
pubmed: 31818638
Nature. 2001 May 24;411(6836):480-4
pubmed: 11373681
Clin Neurol Neurosurg. 2020 Jul;194:105837
pubmed: 32311618
Clin Chim Acta. 2021 May;516:8-14
pubmed: 33485901
Viruses. 2022 Apr 04;14(4):
pubmed: 35458486
Cytokine. 2012 Nov;60(2):468-72
pubmed: 22705151
Br J Pharmacol. 2012 Jan;165(2):313-27
pubmed: 21718299
Nature. 2001 Jan 18;409(6818):307-12
pubmed: 11201732
Diabetes. 2023 Mar 1;72(3):405-414
pubmed: 36448982
Peptides. 2007 Jun;28(6):1317-30
pubmed: 17540480
Front Endocrinol (Lausanne). 2019 Nov 22;10:822
pubmed: 31824433