Amyloid Precursor Protein and Alzheimer's Disease.
Alzheimer’s disease
SRP-dependent targeting
amyloid beta
amyloid precursor protein (APP)
membrane proteins
neurodegenerative disease
protein biogenesis
protein transport
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
30 Sep 2023
30 Sep 2023
Historique:
received:
30
07
2023
revised:
20
09
2023
accepted:
26
09
2023
medline:
2
11
2023
pubmed:
14
10
2023
entrez:
14
10
2023
Statut:
epublish
Résumé
Alzheimer's disease (AD) is one of the most common neurodegenerative disorders associated with age or inherited mutations. It is characterized by severe dementia in the late stages that affect memory, cognitive functions, and daily life overall. AD progression is linked to the accumulation of cytotoxic amyloid beta (Aβ) and hyperphosphorylated tau protein combined with other pathological features such as synaptic loss, defective energy metabolism, imbalances in protein, and metal homeostasis. Several treatment options for AD are under investigation, including antibody-based therapy and stem cell transplantation. Amyloid precursor protein (APP) is a membrane protein considered to play a main role in AD pathology. It is known that APP in physiological conditions follows a non-amyloidogenic pathway; however, it can proceed to an amyloidogenic scenario, which leads to the generation of extracellular deleterious Aβ plaques. Not all steps of APP biogenesis are clear so far, and these questions should be addressed in future studies. AD is a complex chronic disease with many factors that contribute to disease progression.
Identifiants
pubmed: 37834241
pii: ijms241914794
doi: 10.3390/ijms241914794
pmc: PMC10573485
pii:
doi:
Substances chimiques
Amyloid beta-Peptides
0
Amyloid beta-Protein Precursor
0
Membrane Proteins
0
APP protein, human
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : the Center of Excellence for Translational Neuroscience and Therapeutics (CTNT) and the TTUHSC Office of Research
ID : CTNT-OR 2022-04 AKMM
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