Hepatic SPARC Expression Is Associated with Inflammasome Activation during the Progression of Non-Alcoholic Fatty Liver Disease in Both Mice and Morbidly Obese Patients.
IL-1β
inflammasome
non-alcoholic fatty liver disease
secreted protein acidic and rich in cysteine
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
02 Oct 2023
02 Oct 2023
Historique:
received:
02
09
2023
revised:
23
09
2023
accepted:
28
09
2023
medline:
23
10
2023
pubmed:
14
10
2023
entrez:
14
10
2023
Statut:
epublish
Résumé
The severity of non-alcoholic fatty liver disease (NAFLD) ranges from simple steatosis to steatohepatitis, and it is not yet clearly understood which patients will progress to liver fibrosis or cirrhosis. SPARC (Secreted Protein Acidic and Rich in Cysteine) has been involved in NAFLD pathogenesis in mice and humans. The aim of this study was to investigate the role of SPARC in inflammasome activation, and to evaluate the relationship between the hepatic expression of inflammasome genes and the biochemical and histological characteristics of NAFLD in obese patients. In vitro studies were conducted in a macrophage cell line and primary hepatocyte cultures to assess the effect of SPARC on inflammasome. A NAFLD model was established in SPARC knockout (SPARC
Identifiants
pubmed: 37834291
pii: ijms241914843
doi: 10.3390/ijms241914843
pmc: PMC10573696
pii:
doi:
Substances chimiques
Inflammasomes
0
Osteonectin
0
SPARC protein, human
0
SPARC protein, mouse
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Austral University
ID : T-14
Organisme : Austral University
ID : T-13
Organisme : Agencia Nacional de Promoción Científica y Tecnológica (ANPCyT)
ID : PICT 2018/03097
Organisme : Agencia Nacional de Promoción Científica y Tecnológica (ANPCyT)
ID : PICT 2018/ 4053
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