Genotype Prevalence of Lactose Deficiency, Vitamin D Deficiency, and the Vitamin D Receptor in a Chilean Inflammatory Bowel Disease Cohort: Insights from an Observational Study.
Latin American
inflammatory bowel disease
lactose intolerance
single-nucleotide polymorphism
vitamin D
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
03 Oct 2023
03 Oct 2023
Historique:
received:
30
08
2023
revised:
28
09
2023
accepted:
29
09
2023
medline:
1
11
2023
pubmed:
14
10
2023
entrez:
14
10
2023
Statut:
epublish
Résumé
Lactose intolerance (LI) and vitamin D deficiency (VDD) have been linked to inflammatory bowel disease (IBD). We conducted an observational study in 192 Chilean IBD patients to investigate the prevalence of a specific gene variant (LCT-13910 CC genotype) associated with LI and the prevalence of VDD/Vitamin D Receptor (VDR) gene variants. Blood samples were analyzed using Illumina's Infinium Global Screening Array. The LCT-13910 CC genotype was found in 61% of IBD patients, similar to Chilean Hispanic controls and lower than Chilean Amerindian controls. The frequency of the LCT-13910-C allele in Chilean IBD patients (0.79) was comparable to the general population and higher than Europeans (0.49). Regarding VDR and VDD variants, in our study, the rs12785878-GG variant was associated with an increased risk of IBD (OR = 2.64, CI = 1.61-4.32;
Identifiants
pubmed: 37834314
pii: ijms241914866
doi: 10.3390/ijms241914866
pmc: PMC10573577
pii:
doi:
Substances chimiques
Lactose
J2B2A4N98G
Receptors, Calcitriol
0
Vitamin D
1406-16-2
Types de publication
Observational Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Fondecyt
ID : Tamara Pérez-Jeldres was supported by ANID, Chile. Project Fondecyt Initiation [Grant Number 11220147]
Organisme : Fondecyt
ID : Manuel Alvarez-Lobos was supported by ANID, Chile. Project Fondecyt Regular [Grant 1211344]
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