MicroRNAs in Endometriosis: Insights into Inflammation and Progesterone Resistance.
endometriosis
inflammation
microRNA
progesterone resistance
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
09 Oct 2023
09 Oct 2023
Historique:
received:
10
09
2023
revised:
03
10
2023
accepted:
05
10
2023
medline:
23
10
2023
pubmed:
14
10
2023
entrez:
14
10
2023
Statut:
epublish
Résumé
Endometriosis, a non-malignant gynecological disorder influenced by estrogen, involves the growth of endometrial tissue outside the uterus. Its development includes processes such as inflammation, progesterone resistance, angiogenesis, and cell proliferation. Epigenetic factors, particularly the dysregulation of microRNAs (miRNAs), have emerged as key factors in these mechanisms in endometriosis. This review aims to unveil the intricate molecular processes that control inflammation, progesterone resistance, and miRNA functions in endometriosis. In addition, it provides a comprehensive overview of the current understanding regarding the involvement of miRNAs in the inflammatory aspects of this condition. This synthesis encompasses research investigating the molecular underpinnings of inflammation, along with the biogenesis and roles of miRNAs in endometriosis. Furthermore, it examines human studies and functional analyses to establish the intricate connection between miRNAs, inflammation, and progesterone resistance in the context of endometriosis. The results highlight the significant impact of dysregulated miRNAs on the inflammatory pathways and hormonal imbalances characteristic of endometriosis. Consequently, miRNAs hold promise as potential non-invasive biomarkers and targeted therapeutic agents aimed at addressing inflammation and enhancing the response to progesterone treatment in individuals with endometriosis.
Identifiants
pubmed: 37834449
pii: ijms241915001
doi: 10.3390/ijms241915001
pmc: PMC10573326
pii:
doi:
Substances chimiques
MicroRNAs
0
Progesterone
4G7DS2Q64Y
Receptors, Progesterone
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Fundamental Research Grant Scheme (FRGS)
ID : FRGS/1/2019/SKK08/UKM/02/7
Références
J Med Life. 2014 Sep 15;7(3):349-57
pubmed: 25408753
Endocrinology. 2019 Nov 1;160(11):2495-2516
pubmed: 31504401
Chin Med J (Engl). 2020 Nov 4;134(1):20-27
pubmed: 33395071
Biol Reprod. 2020 Apr 24;102(5):1011-1019
pubmed: 31950153
J Biol Chem. 2012 Apr 20;287(17):13899-910
pubmed: 22378788
J Minim Invasive Gynecol. 2015 Jul-Aug;22(5):719-26
pubmed: 25757811
Eur Rev Med Pharmacol Sci. 2017 May;21(9):2027-2033
pubmed: 28537685
Front Biosci (Elite Ed). 2012 Jan 01;4(1):23-40
pubmed: 22201853
Annu Rev Pathol. 2020 Jan 24;15:71-95
pubmed: 31479615
Nucleic Acids Res. 2019 Jan 8;47(D1):D155-D162
pubmed: 30423142
Endocrinology. 2008 Mar;149(3):1190-204
pubmed: 18048499
Int J Mol Sci. 2020 Apr 17;21(8):
pubmed: 32316608
Front Endocrinol (Lausanne). 2020 Jan 29;10:935
pubmed: 32063886
Int J Mol Sci. 2013 Mar 08;14(3):5519-44
pubmed: 23528856
Clin Chem. 2010 Nov;56(11):1733-41
pubmed: 20847327
Life Sci. 2020 Feb 1;242:117190
pubmed: 31863773
Fertil Steril. 2011 Mar 1;95(3):889-94
pubmed: 21269613
Mol Endocrinol. 2009 Feb;23(2):265-75
pubmed: 19074548
Int J Fertil. 1991 Jan-Feb;36(1):39-42
pubmed: 1672675
Mol Cell Endocrinol. 2006 Mar 27;248(1-2):94-103
pubmed: 16406281
Biol Reprod. 2019 May 1;100(5):1135-1146
pubmed: 30721951
J Clin Endocrinol Metab. 2011 Dec;96(12):E1925-33
pubmed: 21956427
Front Endocrinol (Lausanne). 2022 Oct 26;13:1020827
pubmed: 36387918
Yale J Biol Med. 2020 Sep 30;93(4):571-577
pubmed: 33005121
Diagn Cytopathol. 2021 Jun;49(6):677-681
pubmed: 33555651
Hum Reprod. 1997 Nov;12(11):2528-33
pubmed: 9436700
Mol Endocrinol. 2011 May;25(5):821-32
pubmed: 21436257
Ann Lab Med. 2020 Sep;40(5):390-397
pubmed: 32311852
Front Surg. 2015 Jun 22;2:23
pubmed: 26157800
Biomedicines. 2020 Oct 27;8(11):
pubmed: 33121166
Mol Hum Reprod. 1999 Aug;5(8):742-7
pubmed: 10421802
Am J Pathol. 2014 Jul;184(7):1930-9
pubmed: 24910298
Mol Cell Endocrinol. 2015 Jan 5;399:95-102
pubmed: 25150622
J Cell Mol Med. 2018 Nov;22(11):5346-5353
pubmed: 30063121
Int J Mol Med. 2019 Jan;43(1):358-370
pubmed: 30431056
Fertil Steril. 2010 Nov;94(6):1985-94
pubmed: 20188363
Int J Mol Med. 2015 Apr;35(4):1119-25
pubmed: 25625784
Taiwan J Obstet Gynecol. 2019 May;58(3):401-408
pubmed: 31122533
Fertil Steril. 2015 May;103(5):1252-60.e1
pubmed: 25772772
J Cell Physiol. 2016 Jan;231(1):25-30
pubmed: 26031493
Fertil Steril. 2008 Jul;90(1):217-20
pubmed: 17889859
Int J Mol Sci. 2020 Mar 04;21(5):
pubmed: 32143439
Reprod Sci. 2017 Mar;24(3):376-381
pubmed: 27655771
Mol Cell Biochem. 2021 Mar;476(3):1575-1588
pubmed: 33400022
Cell Death Discov. 2023 Jan 25;9(1):28
pubmed: 36693853
Hum Reprod. 2009 Feb;24(2):325-32
pubmed: 19049988
Semin Reprod Med. 2017 Mar;35(2):173-180
pubmed: 28212593
Carcinogenesis. 2018 Feb 9;39(2):98-108
pubmed: 29126102
Fertil Steril. 2000 Dec;74(6):1187-91
pubmed: 11119748
Methods Mol Biol. 2017;1617:57-67
pubmed: 28540676
Int J Mol Sci. 2019 Nov 10;20(22):
pubmed: 31717614
Fertil Steril. 1997 Sep;68(3):393-401
pubmed: 9314903
Trends Mol Med. 2014 Aug;20(8):460-9
pubmed: 25027972
EMBO Mol Med. 2012 Mar;4(3):206-17
pubmed: 22307873
RNA Biol. 2016 Nov;13(11):1084-1088
pubmed: 27687236
J Clin Endocrinol Metab. 2000 Aug;85(8):2897-902
pubmed: 10946900
Front Endocrinol (Lausanne). 2022 Feb 28;13:827724
pubmed: 35295981
Front Endocrinol (Lausanne). 2018 Aug 03;9:402
pubmed: 30123182
Reprod Biol. 2022 Mar;22(1):100592
pubmed: 34995817
Hum Reprod Update. 2020 Jun 18;26(4):565-585
pubmed: 32412587
Hum Reprod Update. 2015 Mar-Apr;21(2):155-73
pubmed: 25406186
Cells. 2022 Mar 24;11(7):
pubmed: 35406659
Mol Cell Biochem. 2011 Sep;355(1-2):17-25
pubmed: 21526342
Cells. 2022 Jun 25;11(13):
pubmed: 35805112
J Clin Endocrinol Metab. 2018 Jan 1;103(1):64-74
pubmed: 29040578
Mol Med Rep. 2021 May;23(5):
pubmed: 33760149
Cells. 2023 Jan 13;12(2):
pubmed: 36672241
Endocrinology. 2018 Jul 1;159(7):2554-2562
pubmed: 29762665
Hum Reprod. 2023 Jun 1;38(6):1124-1134
pubmed: 37071897
J Reprod Immunol. 2016 Sep;117:39-44
pubmed: 27371900
Fertil Steril. 2020 Jun;113(6):1232-1241
pubmed: 32482255
Front Immunol. 2023 Feb 14;14:1134663
pubmed: 36865552
Reproduction. 2012 Apr;143(4):531-8
pubmed: 22279148
J Clin Endocrinol Metab. 2014 Mar;99(3):E427-37
pubmed: 24423359
Fertil Steril. 2013 Mar 1;99(3):871-881.e1
pubmed: 23206733
Fertil Steril. 2016 Aug;106(2):402-9
pubmed: 27179784
J Immunol. 2015 Sep 15;195(6):2591-600
pubmed: 26259585
Acta Obstet Gynecol Scand. 2017 Jun;96(6):623-632
pubmed: 28423456
Am J Reprod Immunol Microbiol. 1987 Mar;13(3):78-82
pubmed: 3605484
Gene. 2021 Feb 5;768:145334
pubmed: 33278550
Fertil Steril. 2018 Apr;109(4):675-684.e2
pubmed: 29605406
J Immunol Res. 2018 Sep 12;2018:6285813
pubmed: 30276219
Expert Rev Mol Med. 2007 Jan 16;9(2):1-20
pubmed: 17227592
Gynecol Endocrinol. 2020 May;36(5):441-444
pubmed: 31663401
Inflammation. 2023 Jun 30;:
pubmed: 37389684
Am J Pathol. 2015 Aug;185(8):2286-97
pubmed: 26073038
Pediatr Res. 2007 May;61(5 Pt 2):24R-29R
pubmed: 17413852
Hum Reprod. 2016 Nov;31(11):2598-2608
pubmed: 27619769
J Clin Endocrinol Metab. 2017 Jan 1;102(1):141-149
pubmed: 27778641
Eur J Obstet Gynecol Reprod Biol. 2018 Nov;230:36-40
pubmed: 30240947
J Biomed Biotechnol. 2010;2010:369549
pubmed: 20300586
Hum Reprod Update. 2018 Jul 1;24(4):497-515
pubmed: 29697794
J Pathol. 2019 Dec;249(4):485-497
pubmed: 31418859
Reprod Sci. 2015 Sep;22(9):1153-61
pubmed: 26037298
Int J Fertil Steril. 2019 Jul;13(2):127-134
pubmed: 31037923
Cancer Biol Ther. 2017 Oct 3;18(10):801-805
pubmed: 28876975
Reproduction. 2017 Dec;154(6):815-825
pubmed: 28971893
J Obstet Gynaecol Res. 2023 Mar;49(3):956-965
pubmed: 36572643
Int J Mol Sci. 2019 Dec 24;21(1):
pubmed: 31878193
Int J Mol Sci. 2019 Aug 05;20(15):
pubmed: 31387263
Am J Reprod Immunol. 2017 Apr;77(4):
pubmed: 28138997
J Clin Endocrinol Metab. 2009 Feb;94(2):615-22
pubmed: 19001520
J Clin Endocrinol Metab. 2018 Dec 1;103(12):4561-4568
pubmed: 30357380
Histol Histopathol. 2014 Oct;29(10):1217-33
pubmed: 24831778
Eur Rev Med Pharmacol Sci. 2016 Oct;20(20):4380-4389
pubmed: 27831632
Cell. 2015 Nov 5;163(4):960-74
pubmed: 26544941
Mol Cell Endocrinol. 2012 May 15;355(1):15-24
pubmed: 22330642
Int J Cancer. 2000 Jan 15;85(2):182-8
pubmed: 10629075
Biol Reprod. 2007 Oct;77(4):681-7
pubmed: 17625110
Elife. 2015 Aug 12;4:
pubmed: 26267216