Insulin Receptor Isoforms and Insulin Growth Factor-like Receptors: Implications in Cell Signaling, Carcinogenesis, and Chemoresistance.
Humans
Insulin
/ metabolism
Receptor, Insulin
/ metabolism
Drug Resistance, Neoplasm
/ genetics
Receptor, IGF Type 1
/ genetics
Signal Transduction
Protein Isoforms
/ genetics
Insulin, Regular, Human
Neoplasms
/ drug therapy
Somatomedins
Carcinogenesis
/ genetics
Insulin-Like Growth Factor I
/ metabolism
IGF signal transduction
chemoresistance
insulin growth factor-like receptors
insulin receptor isoforms
insulin signal transduction
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
09 Oct 2023
09 Oct 2023
Historique:
received:
21
08
2023
revised:
22
09
2023
accepted:
26
09
2023
medline:
23
10
2023
pubmed:
14
10
2023
entrez:
14
10
2023
Statut:
epublish
Résumé
This comprehensive review thoroughly explores the intricate involvement of insulin receptor (IR) isoforms and insulin-like growth factor receptors (IGFRs) in the context of the insulin and insulin-like growth factor (IGF) signaling (IIS) pathway. This elaborate system encompasses ligands, receptors, and binding proteins, giving rise to a wide array of functions, including aspects such as carcinogenesis and chemoresistance. Detailed genetic analysis of IR and IGFR structures highlights their distinct isoforms, which arise from alternative splicing and exhibit diverse affinities for ligands. Notably, the overexpression of the IR-A isoform is linked to cancer stemness, tumor development, and resistance to targeted therapies. Similarly, elevated IGFR expression accelerates tumor progression and fosters chemoresistance. The review underscores the intricate interplay between IRs and IGFRs, contributing to resistance against anti-IGFR drugs. Consequently, the dual targeting of both receptors could present a more effective strategy for surmounting chemoresistance. To conclude, this review brings to light the pivotal roles played by IRs and IGFRs in cellular signaling, carcinogenesis, and therapy resistance. By precisely modulating these receptors and their complex signaling pathways, the potential emerges for developing enhanced anti-cancer interventions, ultimately leading to improved patient outcomes.
Identifiants
pubmed: 37834454
pii: ijms241915006
doi: 10.3390/ijms241915006
pmc: PMC10573852
pii:
doi:
Substances chimiques
Insulin
0
Receptor, Insulin
EC 2.7.10.1
Receptor, IGF Type 1
EC 2.7.10.1
Protein Isoforms
0
Insulin, Regular, Human
0
Somatomedins
0
Insulin-Like Growth Factor I
67763-96-6
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Références
Front Endocrinol (Lausanne). 2016 Sep 28;7:132
pubmed: 27733843
Proc Natl Acad Sci U S A. 2020 Mar 24;117(12):6733-6740
pubmed: 32156724
J Biol Chem. 2014 Feb 21;289(8):4626-33
pubmed: 24398690
Pancreas. 1997 Nov;15(4):367-73
pubmed: 9361090
Cell Mol Life Sci. 2000 Jul;57(7):1050-93
pubmed: 10961344
Cell. 2019 Apr 18;177(3):722-736.e22
pubmed: 30955890
Nat Rev Mol Cell Biol. 2001 Oct;2(10):769-76
pubmed: 11584304
J Leukoc Biol. 2019 Mar;105(3):519-530
pubmed: 30657605
Cell. 2004 Jan 23;116(2):191-203
pubmed: 14744431
Mol Endocrinol. 1989 Aug;3(8):1263-9
pubmed: 2779582
Trends Cell Biol. 2007 Mar;17(3):118-26
pubmed: 17197185
Oncotarget. 2014 May 15;5(9):2723-35
pubmed: 24809298
Proc Natl Acad Sci U S A. 2015 Sep 15;112(37):11636-41
pubmed: 26324892
Sci Rep. 2017 Jul 14;7(1):5387
pubmed: 28710407
Nat Struct Mol Biol. 2010 Jun;17(6):732-9
pubmed: 20473314
Oncol Rev. 2013 Apr 22;7(1):e3
pubmed: 25992224
J Biol Chem. 2003 Apr 25;278(17):14599-602
pubmed: 12637568
J Biol Chem. 1985 Aug 5;260(16):9435-42
pubmed: 2991246
Cold Spring Harb Perspect Biol. 2014 Jan 01;6(1):
pubmed: 24384568
J Pathol. 2017 Jun;242(2):193-205
pubmed: 28295307
Biochem J. 1997 Oct 1;327 ( Pt 1):209-15
pubmed: 9355755
J Cell Sci. 2011 Mar 1;124(Pt 5):801-11
pubmed: 21303927
Genes (Basel). 2019 Nov 29;10(12):
pubmed: 31795422
Carcinogenesis. 2020 Sep 24;41(9):1294-1305
pubmed: 31958132
J Biol Chem. 2005 May 13;280(19):19426-35
pubmed: 15764603
Endocrinology. 2002 Sep;143(9):3259-67
pubmed: 12193537
Digestion. 2009;80(3):148-58
pubmed: 19713703
Semin Cancer Biol. 2005 Jun;15(3):215-23
pubmed: 15826836
Clin Cancer Res. 2007 Sep 15;13(18 Pt 2):5549s-5555s
pubmed: 17875788
Br J Surg. 2018 Jan;105(1):75-85
pubmed: 29116653
J Cancer. 2021 Jul 3;12(17):5310-5319
pubmed: 34335947
Mol Cell Biol. 1994 Jun;14(6):3604-12
pubmed: 8196606
J Cell Sci. 2005 Oct 1;118(Pt 19):4577-86
pubmed: 16179614
J Biol Chem. 2006 Sep 8;281(36):25869-74
pubmed: 16831875
Endocr Relat Cancer. 2019 Jan 1;26(1):197-214
pubmed: 30121624
Proc Natl Acad Sci U S A. 1991 Jan 15;88(2):580-4
pubmed: 1846448
Curr Drug Metab. 2018;19(9):793-797
pubmed: 29663879
Am J Pathol. 2003 Jan;162(1):3-6
pubmed: 12507883
Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12429-34
pubmed: 16894147
J Biol Chem. 1994 May 13;269(19):13922-8
pubmed: 8188672
Nature. 2001 Dec 13;414(6865):799-806
pubmed: 11742412
J Cell Mol Med. 2019 Apr;23(4):2293-2302
pubmed: 30614613
Endocr Relat Cancer. 2006 Dec;13 Suppl 1:S33-43
pubmed: 17259557
Mol Endocrinol. 1999 May;13(5):787-96
pubmed: 10319328
Science. 1988 Jul 1;241(4861):42-52
pubmed: 3291115
Cell Metab. 2006 Jul;4(1):89-96
pubmed: 16814735
J Biol Chem. 1990 Dec 5;265(34):21172-8
pubmed: 2174437
PLoS One. 2012;7(7):e41992
pubmed: 22848683
Mol Cell Biol. 2001 Apr;21(7):2521-32
pubmed: 11259600
Diabetes. 2006 Oct;55(10):2835-42
pubmed: 17003350
Biochemistry. 1980 Jan 8;19(1):70-6
pubmed: 6986166
Science. 2007 Mar 16;315(5818):1576-9
pubmed: 17322030
Mol Cell Biochem. 1998 May;182(1-2):3-11
pubmed: 9609109
Endocr Rev. 2017 Oct 1;38(5):379-431
pubmed: 28973479
Genes Chromosomes Cancer. 2003 Feb;36(2):113-20
pubmed: 12508239
Cancer. 2012 Feb 1;118(3):740-9
pubmed: 21751203
Proteins. 2008 Apr;71(1):426-39
pubmed: 17957771
Cell Physiol Biochem. 2014;34(5):1578-88
pubmed: 25402559
Biochem J. 2012 Aug 15;446(1):113-23
pubmed: 22646166
Int J Mol Sci. 2021 May 23;22(11):
pubmed: 34071140
Growth Factors. 2015;33(5-6):337-46
pubmed: 26430715
Proc Natl Acad Sci U S A. 1971 Jun;68(6):1264-8
pubmed: 5288373
Nat Rev Drug Discov. 2006 Mar;5(3):219-34
pubmed: 16518375
Mol Pathol. 2001 Jun;54(3):121-4
pubmed: 11376121
Hum Genet. 2016 Aug;135(8):851-67
pubmed: 27215579
Mol Endocrinol. 1996 Jun;10(6):631-41
pubmed: 8776723
Curr Pharm Des. 2007;13(33):3358-67
pubmed: 18045190
Clin Cancer Res. 2011 Sep 15;17(18):6052-60
pubmed: 21750201
Nature. 1994 Nov 10;372(6502):186-90
pubmed: 7526222
Cancer Res. 2001 Aug 15;61(16):6276-80
pubmed: 11507082
Nat Cell Biol. 2005 Jun;7(6):601-11
pubmed: 15895078
Mol Neurobiol. 2017 May;54(4):2636-2658
pubmed: 26993302
Genome Biol. 2009;10(10):242
pubmed: 19857271
Am J Physiol Endocrinol Metab. 2000 Jan;278(1):E127-33
pubmed: 10644546
Biochem Pharmacol. 2008 Oct 1;76(7):873-83
pubmed: 18718450
Annu Rev Biochem. 1992;61:307-30
pubmed: 1323236
Mol Med Rep. 2010 Jan-Feb;3(1):189-93
pubmed: 21472221
Endocrinology. 1991 Oct;129(4):2058-66
pubmed: 1655392
Biochem J. 1998 Aug 1;333 ( Pt 3):471-90
pubmed: 9677303
Nucleic Acids Res. 2014;42(17):10873-87
pubmed: 25183524
Front Endocrinol (Lausanne). 2013 Aug 09;4:98
pubmed: 23950756
Oncotarget. 2017 Jun 27;8(26):43248-43270
pubmed: 28591735
Nature. 2011 Jun 08;474(7353):649-53
pubmed: 21654750
J Biol Chem. 2004 Jul 9;279(28):29647-53
pubmed: 15131126
Appl Immunohistochem Mol Morphol. 2011 May;19(3):218-25
pubmed: 21217522
Cancer Res. 2008 Dec 15;68(24):10238-46
pubmed: 19074892
Cell. 2004 May 14;117(4):421-6
pubmed: 15137936
Cancer Lett. 2019 May 28;450:155-168
pubmed: 30849481
J Biol Chem. 1980 Feb 25;255(4):1722-31
pubmed: 6986378
PLoS One. 2014 Aug 29;9(8):e106249
pubmed: 25170759
Cancer Lett. 2014 Nov 28;354(2):254-62
pubmed: 25157649
Cell Death Dis. 2019 Nov 20;10(12):876
pubmed: 31748500
EMBO J. 2006 Sep 20;25(18):4271-83
pubmed: 16946708
Nature. 2006 Sep 14;443(7108):218-21
pubmed: 16957736
Breast Cancer Res Treat. 2012 Feb;132(1):131-42
pubmed: 21574055
J Biol Chem. 2012 Mar 30;287(14):11422-36
pubmed: 22318726
J Biol Chem. 2002 Oct 18;277(42):39684-95
pubmed: 12138094
Arch Physiol Biochem. 2008 Feb;114(1):23-37
pubmed: 18465356
Mol Pharmacol. 2015 Feb;87(2):150-61
pubmed: 25391374
Sci Rep. 2016 Aug 16;6:31222
pubmed: 27526875
Int J Mol Sci. 2018 Nov 16;19(11):
pubmed: 30453495
J Cell Physiol. 2000 Apr;183(1):1-9
pubmed: 10699960
Int J Mol Sci. 2020 Feb 09;21(3):
pubmed: 32050495
J Biol Chem. 2001 May 18;276(20):16772-9
pubmed: 11278720
Am J Physiol. 1990 Mar;258(3 Pt 1):E534-42
pubmed: 2156441
Nat Commun. 2023 Jan 4;14(1):57
pubmed: 36599833
Mol Biol Rep. 2014 Dec;41(12):8099-106
pubmed: 25189651
J Biol Chem. 2014 Jul 11;289(28):19769-77
pubmed: 24867955
Diabetologia. 2014 Feb;57(2):347-51
pubmed: 24196191
Annu Rev Cell Biol. 1990;6:597-641
pubmed: 2177343
N Engl J Med. 2008 Mar 13;358(11):1160-74
pubmed: 18337605
Science. 2002 May 31;296(5573):1655-7
pubmed: 12040186
Cancer Biomark. 2015;15(5):653-61
pubmed: 26406954
Gene. 2006 Jan 17;366(1):2-16
pubmed: 16377102
Endocr Rev. 2009 Oct;30(6):586-623
pubmed: 19752219
Proc Natl Acad Sci U S A. 1995 Dec 19;92(26):12146-50
pubmed: 8618861
Diabetologia. 2002 Dec;45(12):1697-702
pubmed: 12488959
Mol Cancer Ther. 2007 Jan;6(1):1-12
pubmed: 17237261
Biochim Biophys Acta Mol Basis Dis. 2020 Jun 1;1866(6):165754
pubmed: 32142859
Future Med Chem. 2009 Sep;1(6):1153-71
pubmed: 21425998
Bioessays. 2015 Sep;37(9):959-67
pubmed: 26241732
Growth Horm IGF Res. 2012 Jun-Aug;22(3-4):108-15
pubmed: 22551578
Mol Nutr Food Res. 2015 Nov;59(11):2303-14
pubmed: 26179126
Cancer Res. 2019 Oct 1;79(19):4828-4839
pubmed: 31416841
Int J Cancer. 1992 Jan 21;50(2):215-22
pubmed: 1370435
Prostate. 2017 Sep;77(12):1288-1300
pubmed: 28726241
Science. 1988 Mar 4;239(4844):1134-7
pubmed: 2964083
Proc Natl Acad Sci U S A. 2010 Jun 15;107(24):10791-8
pubmed: 20457905
Cell. 1991 Jun 14;65(6):1053-61
pubmed: 1828392
Endocrinology. 1995 May;136(5):1978-86
pubmed: 7720646
Oncogene. 2001 Oct 1;20(44):6322-30
pubmed: 11607835
J Clin Endocrinol Metab. 2016 Jul;101(7):2883-91
pubmed: 27088794
Elife. 2014 Sep 25;3:
pubmed: 25255214
FASEB J. 1997 Jan;11(1):60-7
pubmed: 9034167
Br J Cancer. 2001 Jul 6;85(1):74-7
pubmed: 11437405
PLoS One. 2013;8(3):e59092
pubmed: 23527094
Mol Cell Endocrinol. 2015 Jul 5;409:82-91
pubmed: 25797178
Front Endocrinol (Lausanne). 2017 Feb 22;8:31
pubmed: 28275367
J Biol Chem. 1997 Apr 25;272(17):11439-43
pubmed: 9111055
Diabetologia. 2010 Aug;53(8):1743-53
pubmed: 20424816
Genomics. 1995 Jan 20;25(2):365-71
pubmed: 7789969
Cell Mol Life Sci. 2014 Jul;71(13):2403-27
pubmed: 24276851
J Biol Chem. 1994 Dec 23;269(51):32558-64
pubmed: 7798258
Cancer Res. 2013 Jul 1;73(13):3974-86
pubmed: 23633480
Nucleic Acids Res. 2009 Sep;37(17):5881-93
pubmed: 19654240
Genes Cancer. 2011 Mar;2(3):261-74
pubmed: 21779497
Nat Cell Biol. 2001 Mar;3(3):245-52
pubmed: 11231573
Int J Mol Sci. 2020 Mar 05;21(5):
pubmed: 32150843
J Cell Sci. 2013 Dec 15;126(Pt 24):5645-56
pubmed: 24127567
Dev Cell. 2007 Apr;12(4):487-502
pubmed: 17419990
J Clin Endocrinol Metab. 2011 Mar;96(3):766-74
pubmed: 21123448
Oncogene. 2011 Jun 16;30(24):2730-40
pubmed: 21278796
Trends Endocrinol Metab. 2005 May-Jun;16(4):183-9
pubmed: 15860415
Neoplasma. 2020 Jan;67(1):129-136
pubmed: 31847523
Oncogene. 2008 Feb 14;27(8):1106-13
pubmed: 17724476
J Biol Chem. 2005 Jun 3;280(22):20932-6
pubmed: 15799978
Carcinogenesis. 2015 Jun;36(6):648-55
pubmed: 25896444
EMBO J. 2019 Aug 1;38(15):e101964
pubmed: 31267557
Nat Med. 2002 Oct;8(10):1145-52
pubmed: 12244301
Ann N Y Acad Sci. 1995 Sep 7;766:466-8
pubmed: 7486693
Nature. 1998 Feb 26;391(6670):900-4
pubmed: 9495343
Endocrinology. 2009 Aug;150(8):3594-602
pubmed: 19443570
J Clin Endocrinol Metab. 1992 Oct;75(4):1046-53
pubmed: 1383255
Annu Rev Pharmacol Toxicol. 1996;36:615-58
pubmed: 8725404
Biochem J. 2007 May 1;403(3):603-13
pubmed: 17291192
Toxicol Pathol. 2011 Apr;39(3):524-43
pubmed: 21411721
Nat Rev Mol Cell Biol. 2014 Mar;15(3):178-96
pubmed: 24556840
Trends Cell Biol. 2010 Mar;20(3):170-5
pubmed: 20061153
Sci STKE. 2003 Dec 09;2003(212):re15
pubmed: 14668532
Clin Cancer Res. 2008 Oct 15;14(20):6364-70
pubmed: 18927274
Cell Death Dis. 2021 Aug 7;12(8):778
pubmed: 34365465
Proc Natl Acad Sci U S A. 1996 Apr 30;93(9):4181-6
pubmed: 8633037
Endocrinology. 1999 Mar;140(3):1329-37
pubmed: 10067860
J Biol Chem. 2003 Jul 11;278(28):26007-14
pubmed: 12707268
Nat Rev Mol Cell Biol. 2006 Feb;7(2):85-96
pubmed: 16493415
J Biol Chem. 2011 Nov 4;286(44):38427-38438
pubmed: 21900255
Oncotarget. 2016 Feb 16;7(7):7683-700
pubmed: 26655502
Mol Reprod Dev. 1993 Aug;35(4):408-13
pubmed: 8398120
Mol Brain. 2015 Aug 22;8:51
pubmed: 26297026
Eur J Endocrinol. 2011 Apr;164(4):485-9
pubmed: 21292919
Cancer Res. 1991 Apr 1;51(7):1898-903
pubmed: 2004373
PLoS One. 2008;3(11):e3667
pubmed: 18989367
Front Oncol. 2023 Jan 19;12:1067974
pubmed: 36793341
Cancer Res. 2020 Apr 15;80(8):1630-1643
pubmed: 31911550
J Biol Chem. 2010 Aug 13;285(33):25426-37
pubmed: 20519504
Transl Cancer Res. 2021 Jul;10(7):3373-3388
pubmed: 35116643
Nat Genet. 2006 Apr;38(4):431-40
pubmed: 16518401
Biochem Biophys Res Commun. 2012 Jan 6;417(1):588-93
pubmed: 22178073
Front Oncol. 2022 Oct 18;12:871786
pubmed: 36330486
Hum Mol Genet. 2006 Jul 1;15(13):2087-97
pubmed: 16717059
Biochem J. 1993 Mar 1;290 ( Pt 2):419-26
pubmed: 8452530
Diabetologia. 2016 Dec;59(12):2702-2710
pubmed: 27600278
Sci Rep. 2016 Oct 20;6:35391
pubmed: 27762282
Cell Rep. 2015 Oct 6;13(1):15-22
pubmed: 26387957
J Biol Chem. 1993 Oct 15;268(29):21990-6
pubmed: 8408055
Med Oncol. 2012 Jun;29(2):682-5
pubmed: 21347719
J Biol Chem. 2001 Aug 17;276(33):30686-93
pubmed: 11402025
Nature. 1995 Sep 14;377(6545):173-7
pubmed: 7675087
J Biol Chem. 1995 Dec 8;270(49):29176-81
pubmed: 7493944
Biochim Biophys Acta. 1987 Nov 26;916(2):220-6
pubmed: 3676333
J Clin Endocrinol Metab. 1979 Dec;49(6):810-4
pubmed: 511971
J Biol Chem. 2005 Apr 22;280(16):15767-72
pubmed: 15701628
Sci Transl Med. 2011 Feb 16;3(70):70ra13
pubmed: 21325617
Cell Cycle. 2007 Mar 15;6(6):705-13
pubmed: 17374994
Nature. 1987 Sep 24-30;329(6137):301-7
pubmed: 2957598
Mol Cell. 2001 Mar;7(3):559-70
pubmed: 11463381
World J Gastroenterol. 2008 Mar 7;14(9):1394-8
pubmed: 18322954
BMC Cancer. 2010 Jul 06;10:356
pubmed: 20604928
Oncogene. 2002 Nov 28;21(54):8240-50
pubmed: 12447687
J Clin Endocrinol Metab. 2002 Jan;87(1):245-54
pubmed: 11788654
J Surg Oncol. 1998 Sep;69(1):21-7
pubmed: 9762887
J Breast Cancer. 2014 Jun;17(2):113-20
pubmed: 25013431
Endocrinology. 2016 Apr;157(4):1702-8
pubmed: 26862994
Mol Cell Biochem. 1998 May;182(1-2):31-48
pubmed: 9609112
PLoS One. 2012;7(12):e50953
pubmed: 23251408
Cell Commun Signal. 2013 Mar 11;11(1):18
pubmed: 23497114
Target Oncol. 2013 Dec;8(4):253-60
pubmed: 23292309
Sci Rep. 2015 Jan 21;5:7911
pubmed: 25604425
Mol Cell Biol. 2003 Apr;23(8):2720-32
pubmed: 12665574
Ann Oncol. 2013 Mar;24(3):784-91
pubmed: 23104723
EMBO J. 1986 Oct;5(10):2503-12
pubmed: 2877871
Biochemistry. 2015 Sep 15;54(36):5523-32
pubmed: 26322622
Am J Pathol. 1993 Jul;143(1):211-20
pubmed: 8391215
Cancers (Basel). 2023 Feb 01;15(3):
pubmed: 36765890
Mol Endocrinol. 1990 Feb;4(2):235-44
pubmed: 2330003
Mol Cell Biol. 1997 Jan;17(1):427-35
pubmed: 8972223
Anal Chim Acta. 2021 Nov 1;1184:339009
pubmed: 34625254
Hepatology. 2015 Jan;61(1):171-83
pubmed: 25132062
Biochem Biophys Res Commun. 1991 Jun 28;177(3):1013-8
pubmed: 1647764
Front Endocrinol (Lausanne). 2015 Jul 07;6:107
pubmed: 26217307
Front Endocrinol (Lausanne). 2015 Apr 24;6:59
pubmed: 25964777
Mol Cell Biol. 1999 Oct;19(10):7203-15
pubmed: 10490655
Cancer Res. 2007 Jan 1;67(1):391-7
pubmed: 17210722
Patterns (N Y). 2020 Jun 12;1(3):100038
pubmed: 33205106
J Mol Neurosci. 1996 Summer;7(2):111-23
pubmed: 8873895
Biochem J. 1998 Mar 1;330 ( Pt 2):923-32
pubmed: 9480911
Mol Biol Cell. 2008 Mar;19(3):1185-98
pubmed: 18172021
Mol Cell Biol. 2009 Feb;29(3):871-80
pubmed: 19047369
J Biol Chem. 2001 Nov 23;276(47):43980-6
pubmed: 11500492
Mol Cell Biol. 1999 May;19(5):3278-88
pubmed: 10207053
Anticancer Drugs. 2011 Mar;22(3):206-12
pubmed: 21178765
J Biol Chem. 1992 Mar 5;267(7):4638-45
pubmed: 1311316
FASEB J. 2015 Jan;29(1):37-49
pubmed: 25351985
Int J Cancer. 2009 Jun 1;124(11):2559-67
pubmed: 19195023
Cancer Res. 2003 Aug 1;63(15):4384-8
pubmed: 12907608
Matrix Biol. 2014 Apr;35:82-90
pubmed: 24389353
Eur J Cancer. 2010 Dec;46(18):3251-62
pubmed: 20591650
Mol Metab. 2019 Apr;22:21-36
pubmed: 30795914
Nature. 1985 Feb 28-Mar 6;313(6005):756-61
pubmed: 2983222
J Biol Chem. 1999 May 21;274(21):15262-70
pubmed: 10329736
Oncogene. 2014 Nov 6;33(45):5262-73
pubmed: 24186206
Cancer Res. 1996 Jun 15;56(12):2781-8
pubmed: 8665514
EMBO J. 1993 May;12(5):1929-36
pubmed: 8491186
Science. 2006 Sep 15;313(5793):1642-5
pubmed: 16902090
Cell Adh Migr. 2018;12(4):305-314
pubmed: 29486622
Cancer Epidemiol Biomarkers Prev. 2020 Nov;29(11):2332-2342
pubmed: 32856611
Biochim Biophys Acta. 2006 Apr;1765(2):85-100
pubmed: 16378690
Neoplasma. 2012;59(4):424-32
pubmed: 22489698
Cell. 1985 Apr;40(4):747-58
pubmed: 2859121
J Biol Chem. 1995 Jun 30;270(26):15639-43
pubmed: 7541045
Proc Natl Acad Sci U S A. 1989 Jan;86(1):114-8
pubmed: 2911561
Endocrinology. 2003 Jun;144(6):2650-8
pubmed: 12746329
Genes Dev. 1993 Mar;7(3):331-42
pubmed: 8449399
Br J Cancer. 2019 Jan;120(2):218-228
pubmed: 30559346
FEBS Lett. 2014 Nov 3;588(21):3939-46
pubmed: 25240198
BMC Cancer. 2014 Feb 26;14:131
pubmed: 24571613
Nature. 1991 Jul 4;352(6330):73-7
pubmed: 1648180
Br J Cancer. 2009 Jul 7;101(1):71-9
pubmed: 19491901
Methods Mol Biol. 2016;1395:1-18
pubmed: 26910065
Mol Carcinog. 2004 Oct;41(2):98-107
pubmed: 15378648
Science. 1998 May 1;280(5364):737-41
pubmed: 9563950
Prostate. 2009 Jan 1;69(1):33-40
pubmed: 18785179
J Exp Clin Cancer Res. 2023 Mar 28;42(1):73
pubmed: 36978187
Oncotarget. 2015 Jun 30;6(18):16084-105
pubmed: 25840417
Endocr Rev. 1995 Apr;16(2):143-63
pubmed: 7540132
J Biol Chem. 1994 Dec 9;269(49):31107-14
pubmed: 7983051
PLoS One. 2011;6(11):e27869
pubmed: 22132154
Mol Cancer Ther. 2010 Oct;9(10):2652-64
pubmed: 20924128
J Biol Chem. 1995 Oct 6;270(40):23456-60
pubmed: 7559507
Int Rev Cell Mol Biol. 2014;310:39-87
pubmed: 24725424
Int J Cancer. 2003 Nov 20;107(4):564-70
pubmed: 14520693
J Biol Chem. 1995 Sep 22;270(38):22639-44
pubmed: 7673254
Br J Cancer. 2017 Nov 21;117(11):1600-1606
pubmed: 28972962
Endocrinology. 2010 Sep;151(9):4123-32
pubmed: 20610571
Science. 2003 Dec 5;302(5651):1710-1
pubmed: 14657487
Mol Cell Endocrinol. 2015 Nov 15;416:57-69
pubmed: 26300412
J Endocrinol Invest. 2016 Dec;39(12):1365-1376
pubmed: 27368923
Clin Transl Med. 2015 Feb 26;4:6
pubmed: 25852822
Nature. 1995 Dec 21-28;378(6559):785-9
pubmed: 8524413
Cancer Res. 2009 Mar 15;69(6):2443-52
pubmed: 19258511
J Biol Chem. 1997 Aug 22;272(34):21403-7
pubmed: 9261155
Proc Natl Acad Sci U S A. 1979 Oct;76(10):4918-21
pubmed: 291908
Mol Cell Biochem. 2005 Apr;272(1-2):107-18
pubmed: 16010978
Endocrinology. 1995 Nov;136(11):4918-24
pubmed: 7588225
J Cell Mol Med. 2021 May;25(10):4800-4813
pubmed: 33742502
J Biol Chem. 1996 Jan 5;271(1):160-7
pubmed: 8550552
Cell Death Discov. 2022 Jul 25;8(1):337
pubmed: 35879279
Int J Oncol. 2014 Sep;45(3):1241-9
pubmed: 24968760
Biochem Biophys Res Commun. 2001 Jan 19;280(2):428-34
pubmed: 11162534
EMBO J. 1990 Aug;9(8):2409-13
pubmed: 2369896
Biochim Biophys Acta. 2007 Aug;1773(8):1150-60
pubmed: 17229475
Genome Biol. 2018 Aug 10;19(1):110
pubmed: 30097058