Response to Ustekinumab Therapy Is Associated with an Improvement of Nutritional Status in Patients with Crohn's Disease.
BIA
Crohn’s disease
biologics
sarcopenia
ustekinumab
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
22 Sep 2023
22 Sep 2023
Historique:
received:
15
08
2023
revised:
15
09
2023
accepted:
18
09
2023
medline:
14
10
2023
pubmed:
14
10
2023
entrez:
14
10
2023
Statut:
epublish
Résumé
The presence of sarcopenia has been associated with the worst outcome of Crohn's disease (CD). At present, no studies have evaluated the impact of ustekinumab (UST) in terms of its effects on body composition. The aim of this prospective study was to evaluate whether UST treatment could modify the parameters of body composition as assessed by bioelectrical impedance assay (BIA) in patients with CD. We prospectively enrolled consecutive patients with CD treated with UST, evaluating the therapeutic outcome at week 48 in terms of clinical remission and mucosal healing. BIA was performed at baseline and at week 48, assessing body cellular mass, total body water, phase angle, and body mass index. Out of 44 patients enrolled, 26 (59%) were in clinical remission and 22 (50%) achieved mucosal healing at the end of follow up. No significant differences were observed at baseline in all the BIA parameters between responders and non-responders. Phase angle increased over time in responders, while this was not observed in non-responders (test for the interaction between time and outcome,
Identifiants
pubmed: 37834762
pii: jcm12196118
doi: 10.3390/jcm12196118
pmc: PMC10573723
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
Clin Transl Gastroenterol. 2020 May;11(5):e00174
pubmed: 32677804
Intest Res. 2022 Jul;20(3):321-328
pubmed: 34275256
Lancet. 2007 May 12;369(9573):1641-57
pubmed: 17499606
Aliment Pharmacol Ther. 2015 Mar;41(5):419-28
pubmed: 25580985
J Crohns Colitis. 2021 Mar 5;15(3):462-470
pubmed: 32931556
Am J Clin Nutr. 1988 Jul;48(1):16-23
pubmed: 3389323
Nutrients. 2018 Apr 17;10(4):
pubmed: 29673210
Acta Derm Venereol. 2009;89(5):492-7
pubmed: 19734975
Eur J Clin Nutr. 2015 Dec;69(12):1290-7
pubmed: 26220573
Nutrients. 2021 May 12;13(5):
pubmed: 34066229
N Engl J Med. 2016 Nov 17;375(20):1946-1960
pubmed: 27959607
Clin Nutr. 2017 Feb;36(1):49-64
pubmed: 27642056
Nutrients. 2019 Oct 26;11(11):
pubmed: 31717788
Dermatology. 2016;232(6):633-639
pubmed: 28226326
Nutrients. 2020 Jan 31;12(2):
pubmed: 32023881
Eur J Clin Nutr. 2014 Jun;68(6):683-9
pubmed: 24736681
Expert Opin Biol Ther. 2018 Mar;18(3):229-235
pubmed: 29252034
PLoS One. 2017 Jun 23;12(6):e0180036
pubmed: 28644887
Nutrients. 2021 Apr 20;13(4):
pubmed: 33924119
Front Immunol. 2021 Jul 13;12:694217
pubmed: 34326845
Curr Opin Gastroenterol. 2001 Jul;17(4):342-9
pubmed: 17031181
Nutrients. 2022 May 28;14(11):
pubmed: 35684060
Nutrients. 2019 Sep 24;11(10):
pubmed: 31554166
Curr Opin Clin Nutr Metab Care. 2018 Sep;21(5):366-374
pubmed: 29957677
Eur J Clin Nutr. 2000 Jun;54(6):514-21
pubmed: 10878655
J Crohns Colitis. 2020 Jan 1;14(1):4-22
pubmed: 31711158
Monaldi Arch Chest Dis. 2016 Jun 22;84(1-2):733
pubmed: 27374047
Contrast Media Mol Imaging. 2019 May 29;2019:3548284
pubmed: 31275083
Dig Liver Dis. 2017 May;49(5):495-499
pubmed: 28096060
Inflamm Bowel Dis. 2011 Jan;17(1):471-8
pubmed: 20725943
Nutrition. 2008 Jul-Aug;24(7-8):694-702
pubmed: 18499398
N Engl J Med. 2019 Sep 26;381(13):1201-1214
pubmed: 31553833
Eur J Clin Nutr. 2017 Jun;71(6):773-777
pubmed: 28225051
Aliment Pharmacol Ther. 2013 Aug;38(3):213-25
pubmed: 23763279
Nutrients. 2018 Sep 19;10(9):
pubmed: 30235860
Clin Nutr. 2004 Oct;23(5):1226-43
pubmed: 15380917
J Crohns Colitis. 2010 Jun;4(2):144-52
pubmed: 21122498
Intensive Care Med. 2016 Sep;42(9):1445-53
pubmed: 27515162
Inflamm Bowel Dis. 2019 Jan 1;25(1):67-73
pubmed: 29889230
J Endocrinol. 2008 Apr;197(1):1-10
pubmed: 18372227
Expert Opin Biol Ther. 2020 Feb;20(2):193-203
pubmed: 31859538
Inflamm Bowel Dis. 2017 Oct;23(10):1867-1872
pubmed: 28604415
World J Gastroenterol. 2018 Sep 7;24(33):3681-3694
pubmed: 30197475