Review of Outcomes after Salvage Surgery for Recurrent Squamous Cell Carcinoma of the Head and Neck.

chemoradiation head and neck cancer salvage surgery squamous cell

Journal

Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829

Informations de publication

Date de publication:
23 Sep 2023
Historique:
received: 22 08 2023
revised: 14 09 2023
accepted: 20 09 2023
medline: 14 10 2023
pubmed: 14 10 2023
entrez: 14 10 2023
Statut: epublish

Résumé

Surgery with adjuvant chemoradiotherapy or chemoradiotherapy is the mainstay in treatment for advanced stage head and neck squamous cell carcinoma; however, locoregional recurrences are frequent. Salvage surgery could be proposed in selected patients to improve local control, disease-free, and overall survival. Factors for improved disease-free and overall survival in patients treated with salvage surgery include age, tumor location, the initial T stage, HPV status, resection margins, and the time elapsing from the initial treatment. Clinical trials with adjuvant therapies have shown promise after salvage surgery in terms of tolerance and response, but clinical guidelines for using these adjuvant treatments are currently lacking. The aim of this review is to present current knowledge concerning the incidence and management of recurrent head and neck squamous cell carcinoma and current data concerning survival and morbidity after salvage surgery.

Identifiants

pubmed: 37835386
pii: cancers15194692
doi: 10.3390/cancers15194692
pmc: PMC10571840
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

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Auteurs

Dana M Hartl (DM)

Department of Anesthesia, Surgery, and Interventional Radiology, Head and Neck Oncology Service, 94805 Villejuif, France.

Joanne Guerlain (J)

Department of Anesthesia, Surgery, and Interventional Radiology, Head and Neck Oncology Service, 94805 Villejuif, France.

Philippe Gorphe (P)

Department of Anesthesia, Surgery, and Interventional Radiology, Head and Neck Oncology Service, 94805 Villejuif, France.

Madan Kapre (M)

Department of ENT and Head Neck Surgery, Neeti Clinics Nagpur, Nagpur 440010, India.

Neeti Kapre Gupta (N)

Department of ENT and Head Neck Surgery, Neeti Clinics Nagpur, Nagpur 440010, India.

Nabil F Saba (NF)

The Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA.

K Thomas Robbins (KT)

Department of Otolaryngology Head and Neck Surgery, Southern Illinois University Medical School, Springfield, IL 62703, USA.

Ohad Ronen (O)

Department of Otolaryngology-Head and Neck Surgery, Galilee Medical Center Affiliated with Azrieli Faculty of Medicine, Bar Ilan University, Safed 5290002, Israel.

Juan P Rodrigo (JP)

Department of Otolaryngology, Hospital Universitario Central de Asturias, University of Oviedo, IUOPA, ISPA, CIBERONC, 33204 Oviedo, Spain.

Primož Strojan (P)

Institute of Oncology Ljubljana, 1000 Ljubljana, Slovenia.

Antti A Mäkitie (AA)

Department of Otorhinolaryngology-Head and Neck Surgery, Research Program in Systems Oncology, University of Helsinki and Helsinki University Hospital, FI-00029 Helsinki, Finland.

Luiz P Kowalski (LP)

Head and Neck Surgery Department, University of São Paulo Medical School, Sao Paulo 05403-000, Brazil.
Head and Neck Surgery and Otorhinolaryngology Department, A C Camargo Cancer Center, Sao Paulo 01509-001, Brazil.

Jatin P Shah (JP)

Department of Surgery, Head and Neck Service, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Alfio Ferlito (A)

Coordinator of the International Head and Neck Scientific Group, 35100 Padua, Italy.

Classifications MeSH