Radiation Therapy for Gestational Trophoblastic Neoplasia: Forward-Looking Lessons Learnt.
gestational trophoblastic neoplasia
radiation
radiotherapy
rare cancer
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
30 Sep 2023
30 Sep 2023
Historique:
received:
28
07
2023
revised:
20
09
2023
accepted:
27
09
2023
medline:
14
10
2023
pubmed:
14
10
2023
entrez:
14
10
2023
Statut:
epublish
Résumé
Gestational trophoblastic neoplasia (GTN) includes several rare malignant diseases occurring after pregnancy: invasive moles, choriocarcinoma, placental site trophoblastic tumours, and epithelioid trophoblastic tumours. Multidisciplinary protocols including multi-agent chemotherapy, surgery, and occasionally radiotherapy achieve good outcomes for some high-risk metastatic patients. In this narrative review of the published studies on the topic, we have tried to identify the role of radiotherapy. The available studies are mainly small, old, and retrospective, with incomplete data regarding radiotherapy protocols delivering low doses (which can make this disease appear radioresistant in some cases despite high response rates with palliative doses) to wide fields (whole-brain, whole-liver, etc.), which can increase toxicity. Studies considering modern techniques are needed to overcome these limitations and determine the full potential of radiotherapy beyond its antihemorrhagic and palliative roles.
Identifiants
pubmed: 37835511
pii: cancers15194817
doi: 10.3390/cancers15194817
pmc: PMC10571950
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Références
Clin Transl Radiat Oncol. 2022 May 04;35:44-55
pubmed: 35601799
Cancer. 1963 Jun;16:781-7
pubmed: 14020314
J Neurooncol. 2005 Sep;74(2):99-103
pubmed: 16193379
Eur J Cancer. 2020 May;130:228-240
pubmed: 32247260
Cancer Chemother Pharmacol. 2016 Mar;77(3):441-57
pubmed: 26811177
J Clin Pathol. 2004 Oct;57(10):1009-14
pubmed: 15452150
Cancer. 1983 Nov 1;52(9):1728-35
pubmed: 6684500
Signal Transduct Target Ther. 2021 Nov 22;6(1):404
pubmed: 34803167
ACS Appl Mater Interfaces. 2020 Jan 29;12(4):4231-4240
pubmed: 31912727
Cancer. 1981 Jul 15;48(2):384-94
pubmed: 7237407
Int J Mol Sci. 2022 Sep 06;23(18):
pubmed: 36142122
Mod Pathol. 2011 May;24(5):646-52
pubmed: 21217646
Int J Gynecol Cancer. 2014 Mar;24(3):594-9
pubmed: 24442005
Int J Clin Oncol. 2019 Feb;24(2):153-160
pubmed: 30242539
Cancers (Basel). 2020 Oct 17;12(10):
pubmed: 33080914
Obstet Gynecol. 1987 Apr;69(4):627-30
pubmed: 3822306
Acta Obstet Gynecol Scand. 1996 Jul;75(6):548-50
pubmed: 8693931
J Reprod Med. 2006 Oct;51(10):785-92
pubmed: 17086807
Lancet Oncol. 2009 Nov;10(11):1037-44
pubmed: 19801201
Nat Rev Dis Primers. 2019 Jan 17;5(1):5
pubmed: 30655533
Radiother Oncol. 2021 Sep;162:45-51
pubmed: 34171453
Lancet. 2009 Jul 4;374(9683):48-55
pubmed: 19552948
J Clin Oncol. 1989 Jul;7(7):900-3
pubmed: 2472471
Gynecol Oncol. 2017 Jan;144(1):200-207
pubmed: 27743739
J Clin Oncol. 2013 Jan 10;31(2):280-6
pubmed: 23233709
Ann Oncol. 2013 Oct;24 Suppl 6:vi39-50
pubmed: 23999759
Arch Gynecol Obstet. 2022 Apr;305(4):929-935
pubmed: 34542678
Eur J Gynaecol Oncol. 2014;35(4):359-67
pubmed: 25118474
Dose Response. 2015 May 04;13(1):
pubmed: 26673923
Gynecol Oncol. 1998 Feb;68(2):183-92
pubmed: 9514808
Gynecol Oncol. 2015 Apr;137(1):73-6
pubmed: 25598530
Chin Med J (Engl). 1988 Sep;101(9):637-42
pubmed: 3148406
Obstet Gynecol. 1980 Jan;55(1):89-94
pubmed: 6243407
Front Oncol. 2022 Apr 13;12:859071
pubmed: 35493999
Oncologist. 2010;15(6):593-600
pubmed: 20495216
J Reprod Med. 2012 Jul-Aug;57(7-8):288-92
pubmed: 22838242
Int J Gynecol Pathol. 2017 Mar;36(2):146-153
pubmed: 27362903
Biomed Pharmacother. 2019 Mar;111:119-130
pubmed: 30579251
Am J Obstet Gynecol. 1973 Feb 15;115(4):451-7
pubmed: 4346614
Gynecol Oncol. 1990 Aug;38(2):234-43
pubmed: 2167282
Best Pract Res Clin Obstet Gynaecol. 2012 Jun;26(3):357-70
pubmed: 22285526
Int J Gynaecol Obstet. 2018 Oct;143 Suppl 2:79-85
pubmed: 30306586
Clin Neurol Neurosurg. 1985;87(4):287-90
pubmed: 4092410
Radiat Res. 2000 May;153(5 Pt 1):487-96
pubmed: 10790268
Bull Exp Biol Med. 2019 Jan;166(3):321-325
pubmed: 30627907
Histopathology. 2019 Sep;75(3):421-430
pubmed: 31013360
J Natl Cancer Inst. 2013 Feb 20;105(4):256-65
pubmed: 23291374
Cancer J. 2002 Jan-Feb;8(1):47-54
pubmed: 11895203
Can Med Assoc J. 1968 Jan 6;98(1):1-7
pubmed: 5634572
Cancer Manag Res. 2018 Mar 23;10:557-563
pubmed: 29606889
Best Pract Res Clin Obstet Gynaecol. 2003 Dec;17(6):943-57
pubmed: 14614891
J Radiat Res. 2016 Aug;57 Suppl 1:i99-i105
pubmed: 26983985
Int J Gynecol Cancer. 2004 Sep-Oct;14(5):966-71
pubmed: 15361210
Res Integr Peer Rev. 2019 Mar 26;4:5
pubmed: 30962953
Lancet. 2010 Aug 28;376(9742):717-29
pubmed: 20673583
Cancer. 1996 Oct 15;78(8):1781-8
pubmed: 8859192
Cell Metab. 2018 Feb 6;27(2):281-298
pubmed: 29129785
Expert Rev Mol Med. 2022 Apr 27;24:e21
pubmed: 35586915
Int J Gynaecol Obstet. 2002 Jun;77(3):285-7
pubmed: 12065144
J Natl Compr Canc Netw. 2019 Nov 1;17(11):1374-1391
pubmed: 31693991
Br J Radiol. 2020 Mar;93(1107):20190224
pubmed: 31317768
J Clin Oncol. 2011 Jan 10;29(2):134-41
pubmed: 21041710
Int J Part Ther. 2016 Winter;2(3):428-438
pubmed: 31772953
World Neurosurg. 2018 Jul;115:170-175
pubmed: 29678709
Neuro Oncol. 2017 Apr 1;19(suppl_2):ii2-ii15
pubmed: 28380635
J Immunother Cancer. 2021 Apr;9(4):
pubmed: 33827904
Radiology. 1996 Jul;200(1):277-80
pubmed: 8657926
BJOG. 2021 Feb;128(3):e1-e27
pubmed: 32996207
Br J Cancer. 2012 Nov 20;107(11):1810-4
pubmed: 23059744
Cancers (Basel). 2023 Sep 09;15(18):
pubmed: 37760464
J Reprod Med. 2012 May-Jun;57(5-6):262-9
pubmed: 22696824
Gynecol Oncol. 2007 Mar;104(3):691-4
pubmed: 17137617
Pathol Res Pract. 2010 Jan 15;206(1):19-23
pubmed: 19836147
J Reprod Med. 2014 May-Jun;59(5-6):199-203
pubmed: 24937957
Cancer. 1985 Aug 15;56(4):880-2
pubmed: 4016680
Oncogene. 2007 Nov 29;26(54):7508-16
pubmed: 17563752
Gynecol Oncol. 1995 Nov;59(2):226-30
pubmed: 7590478
BMC Cancer. 2015 Apr 28;15:318
pubmed: 25927660
Mol Cancer. 2021 Jan 4;20(1):7
pubmed: 33397409
Gynecol Oncol. 1983 Apr;15(2):166-70
pubmed: 6682069
Curr Opin Genet Dev. 2001 Jun;11(3):293-9
pubmed: 11377966
Eur J Gynaecol Oncol. 2000;21(2):184-6
pubmed: 10843482
Sci Rep. 2020 Oct 1;10(1):16328
pubmed: 33004943
Int J Gynaecol Obstet. 2021 Oct;155 Suppl 1:86-93
pubmed: 34669197
Tumori. 2015 Sep-Oct;101(5):578-84
pubmed: 26350185
Gynecol Oncol. 1986 Sep;25(1):73-83
pubmed: 3732921