Pan-Cancer Analysis of Patient Tumor Single-Cell Transcriptomes Identifies Promising Selective and Safe Chimeric Antigen Receptor Targets in Head and Neck Cancer.

CAR-T cell surface targets clinical trials glioblastoma head and neck cancer immunoreceptors immunotherapy single-cell RNA sequencing solid tumors

Journal

Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829

Informations de publication

Date de publication:
08 Oct 2023
Historique:
received: 23 08 2023
revised: 30 09 2023
accepted: 05 10 2023
medline: 14 10 2023
pubmed: 14 10 2023
entrez: 14 10 2023
Statut: epublish

Résumé

Chimeric antigen receptor (CAR) T cell therapies have yielded transformative clinical successes for patients with blood tumors, but their full potential remains to be unleashed against solid tumors. One challenge is finding

Identifiants

pubmed: 37835579
pii: cancers15194885
doi: 10.3390/cancers15194885
pmc: PMC10571718
pii:
doi:

Types de publication

Journal Article

Langues

eng

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Auteurs

Sanna Madan (S)

Cancer Data Science Laboratory, National Cancer Institute, Bethesda, MD 20892, USA.
Department of Computer Science, University of Maryland, College Park, MD 20742, USA.

Sanju Sinha (S)

Cancer Data Science Laboratory, National Cancer Institute, Bethesda, MD 20892, USA.

Tiangen Chang (T)

Cancer Data Science Laboratory, National Cancer Institute, Bethesda, MD 20892, USA.

J Silvio Gutkind (JS)

Moores Cancer Center, University of California San Diego, La Jolla, CA 92093, USA.
Department of Pharmacology, University of California San Diego, La Jolla, CA 92093, USA.

Ezra E W Cohen (EEW)

Moores Cancer Center, University of California San Diego, La Jolla, CA 92093, USA.
Department of Medicine, University of California San Diego, La Jolla, CA 92037, USA.

Alejandro A Schäffer (AA)

Cancer Data Science Laboratory, National Cancer Institute, Bethesda, MD 20892, USA.

Eytan Ruppin (E)

Cancer Data Science Laboratory, National Cancer Institute, Bethesda, MD 20892, USA.

Classifications MeSH