Killer Cell Immunoglobulin-like Receptor Genotypes and Reproductive Outcomes in a Group of Infertile Women: A Romanian Study.
NK cells
Romania
endometrium disorder
infertility
killer cell immunoglobulin-like receptor polymorphism
Journal
Diagnostics (Basel, Switzerland)
ISSN: 2075-4418
Titre abrégé: Diagnostics (Basel)
Pays: Switzerland
ID NLM: 101658402
Informations de publication
Date de publication:
25 Sep 2023
25 Sep 2023
Historique:
received:
14
08
2023
revised:
19
09
2023
accepted:
21
09
2023
medline:
14
10
2023
pubmed:
14
10
2023
entrez:
14
10
2023
Statut:
epublish
Résumé
A growing body of evidence suggests that endometrial immune disorders may be responsible for endometrial dysfunctions that can lead to gynecological and obstetrical pathology. The aim of this study was to explore the potential relationship between different killer cell immunoglobulin-like receptor (KIR) genotypes and reproductive outcomes. We conducted a prospective cohort study that included 104 infertile patients undergoing an in vitro fertilization procedure. All participants underwent clinical and ultrasound examination, genetic evaluation (KIR genotyping), endometrial washing fluid sampling for cytokine determination, endometrial tissue sampling for histologic assessment and hysteroscopic evaluation. Our analysis showed statistically significant lower levels of uterine cytokines TNF-α (
Identifiants
pubmed: 37835791
pii: diagnostics13193048
doi: 10.3390/diagnostics13193048
pmc: PMC10572162
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Ministry of Research, Innovation and Digitization, CCCDI - Executive Agency for Higher Educa-tion, Research, Development & Innovation Funding (UEFISCDI)
ID : PN-III-P2-2.1-PTE-2021-0176
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