Associations between Sleep-Disordered Breathing and Serum Uric Acid and Their Sex Differences: The Nagahama Study.
diabetes mellitus
epidemiologic study
gender difference
sleep-disordered breathing
uric acid
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
30 Sep 2023
30 Sep 2023
Historique:
received:
25
08
2023
revised:
22
09
2023
accepted:
29
09
2023
medline:
23
10
2023
pubmed:
14
10
2023
entrez:
14
10
2023
Statut:
epublish
Résumé
Sleep-disordered breathing (SDB) is often accompanied by noncommunicable diseases (NCDs), including gout. However, the association between serum uric acid (sUA) levels and NCDs is complicated in patients with SDB. We aimed to clarify this issue utilizing large-scale epidemiological data. This community-based study included 9850 inhabitants. SDB and its severity were assessed by a 3% oxygen desaturation index (3% ODI) corrected for sleep duration using wrist actigraphy. The associations between sUA and moderate to severe SDB (MS-SDB) and sUA and NCDs in patients with MS-SDB were analyzed. A total of 7895 subjects were eligible. In females, the prevalence of MS-SDB increased according to an elevation in sUA levels even after adjusting for confounders, and sUA ≥ 5 mg/dL was the threshold. These were not found in males. There was a positive interaction between sUA ≥ 5 mg/dL and female sex for MS-SDB. In females with MS-SDB, the prevalence of diabetes mellitus (DM) increased according to an elevation in sUA levels, and those with sUA ≥ 5 mg/dL showed a higher prevalence of DM than their counterparts. There is a clear correlation between sUA levels and the severity of SDB, and elevated sUA poses a risk for DM in females with MS-SDB.
Identifiants
pubmed: 37836522
pii: nu15194237
doi: 10.3390/nu15194237
pmc: PMC10574205
pii:
doi:
Substances chimiques
Uric Acid
268B43MJ25
Oxygen
S88TT14065
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology in Japan
ID : 25293141, 26670313, 26293198, 17H04182, 17H04126, 17H04123, 18K18450
Organisme : Grants from the Center of Innovation Program and the Global University Project from Japan Science and Technology Agency, Japan Agency for Medical Research and Development (AMED)
ID : dk0207006, dk0207027, ek0109070, ek0109283, ek0109196, ek0109348, kk0205008, ek0210066, ek0210096, ek0210116, and le0110005
Organisme : The Intractable Respiratory Diseases and Pulmonary Hypertension Research Group from the Ministry of Health, Labour and Welfare of Japan
ID : H29-intractable diseases-general-027
Organisme : The Health, Labour and Welfare Sciences Research Grants, and Research on Region Medical
ID : H28-iryo-ippan-016, H30-iryo-ippan-009
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