Tick salivary glycans - a sugar-coated tick bite.
Th2 response
acquired tick resistance
alpha-Gal
alpha-Gal syndrome
glycosylation
tick saliva
Journal
Trends in parasitology
ISSN: 1471-5007
Titre abrégé: Trends Parasitol
Pays: England
ID NLM: 100966034
Informations de publication
Date de publication:
12 2023
12 2023
Historique:
received:
21
07
2023
revised:
22
09
2023
accepted:
22
09
2023
medline:
13
11
2023
pubmed:
15
10
2023
entrez:
14
10
2023
Statut:
ppublish
Résumé
Ticks are hematophagous arthropods that transmit disease-causing pathogens worldwide. Tick saliva deposited into the tick-bite site is composed of an array of immunomodulatory proteins that ensure successful feeding and pathogen transmission. These salivary proteins are often glycosylated, and glycosylation is potentially critical for the function of these proteins. Some salivary glycans are linked to the phenomenon of red meat allergy - an allergic response to red meat consumption in humans exposed to certain tick species. Tick salivary glycans are also invoked in the phenomenon of acquired tick resistance wherein non-natural host species exposed to tick bites develop an immune response that thwarts subsequent tick feeding. This review dwells on our current knowledge of these two phenomena, thematically linked by salivary glycans.
Identifiants
pubmed: 37838514
pii: S1471-4922(23)00233-7
doi: 10.1016/j.pt.2023.09.012
pii:
doi:
Substances chimiques
Sugars
0
Polysaccharides
0
Types de publication
Journal Article
Review
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1100-1113Subventions
Organisme : NIAID NIH HHS
ID : R21 AI128182
Pays : United States
Informations de copyright
Copyright © 2023 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.