Quantitative analysis of gastrointestinal fluid absorption and secretion to estimate luminal fluid dynamics in rats.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
14 10 2023
14 10 2023
Historique:
received:
12
01
2023
accepted:
11
10
2023
medline:
23
10
2023
pubmed:
15
10
2023
entrez:
14
10
2023
Statut:
epublish
Résumé
The drug absorption profile is dependent on the luminal drug concentration, which in turn is influenced by the gastrointestinal (GI) fluid dynamics. In the present study, therefore, we aimed to examine the luminal fluid dynamics by kinetically analyzing fluid absorption and secretion along the GI tract in rats using the in situ closed-loop technique with non-absorbable fluorescein isothiocyanate-dextran 4000 (FD-4) and tritium water labeling ([
Identifiants
pubmed: 37838772
doi: 10.1038/s41598-023-44742-y
pii: 10.1038/s41598-023-44742-y
pmc: PMC10576741
doi:
Substances chimiques
Water
059QF0KO0R
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
17454Informations de copyright
© 2023. Springer Nature Limited.
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