Serum concentration of continuously administered vancomycin influences efficacy and safety in critically ill adults: a systematic review.
Acute kidney injury
Continuous infusion
Intensive care unit
Mortality
Sepsis
Vancomycin concentration
Journal
International journal of antimicrobial agents
ISSN: 1872-7913
Titre abrégé: Int J Antimicrob Agents
Pays: Netherlands
ID NLM: 9111860
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
received:
27
07
2023
revised:
12
09
2023
accepted:
29
09
2023
medline:
4
12
2023
pubmed:
16
10
2023
entrez:
15
10
2023
Statut:
ppublish
Résumé
Vancomycin is used to treat Gram-positive infections in critically ill adults. For vancomycin administered by continuous infusion (CI), various target ranges have been used, ranging from 15-20 mg/L to 30-40 mg/L. This systematic literature review was conducted to investigate the impact of steady-state serum concentration (C Relevant literature was identified by searching two electronic databases (PubMed, Cochrane Library) and Google Scholar from inception until July 2023, focusing on studies reporting measured C Twenty-one publications were included with a total of 2949 patients. Mortality was higher (two studies, n = 388 patients) and clinical cure was lower (one study, n = 40 patients) with C Despite sparse data availability, the target range of 15-25 mg/L in CI may increase clinical cure and reduce mortality and AKI. In future research, vancomycin C
Identifiants
pubmed: 37839714
pii: S0924-8579(23)00279-0
doi: 10.1016/j.ijantimicag.2023.107005
pii:
doi:
Substances chimiques
Vancomycin
6Q205EH1VU
Anti-Bacterial Agents
0
Types de publication
Systematic Review
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
107005Informations de copyright
Copyright © 2023 Elsevier Ltd and International Society of Antimicrobial Chemotherapy. All rights reserved.