Maternal prenatal social experiences and offspring epigenetic age acceleration from birth to mid-childhood.
Cohort study
Epigenetic age acceleration
Experiences of discrimination
Maternal-offspring dyads
Prenatal period
Social exposures
Journal
Annals of epidemiology
ISSN: 1873-2585
Titre abrégé: Ann Epidemiol
Pays: United States
ID NLM: 9100013
Informations de publication
Date de publication:
Feb 2024
Feb 2024
Historique:
received:
12
07
2023
revised:
27
09
2023
accepted:
10
10
2023
medline:
29
1
2024
pubmed:
16
10
2023
entrez:
15
10
2023
Statut:
ppublish
Résumé
Investigate associations of maternal social experiences with offspring epigenetic age acceleration (EAA) from birth through mid-childhood among 205 mother-offspring dyads of minoritized racial and ethnic groups. We used linear regression to examine associations of maternal experiences of racial bias or discrimination (0 = none, 1-2 = intermediate, or 3+ = high), social support (tertile 1 = low, 2 = intermediate, 3 = high), and socioeconomic status index (tertile 1 = low, 2 = intermediate, 3 = high) during the prenatal period with offspring EAA according to Horvath's Pan-Tissue, Horvath's Skin and Blood, and Intrinsic EAA clocks at birth, 3 years, and 7 years. In comparison to children of women who did not experience any racial bias or discrimination, those whose mothers reported highest levels of racial bias or discrimination had lower Pan-Tissue clock EAA in early (-0.50 years; 90% CI: -0.91, -0.09) and mid-childhood (-0.75 years; -1.41, -0.08). We observed similar associations for the Skin and Blood clock and Intrinsic EAA. Maternal experiences of discrimination were not associated with Pan-Tissue EAA at birth. Neither maternal social support nor socioeconomic status predicted offspring EAA. Children whose mothers experienced higher racial bias or discrimination exhibited slower EAA. Future studies are warranted to confirm these findings and establish associations of early-life EAA with long-term health outcomes.
Identifiants
pubmed: 37839726
pii: S1047-2797(23)00192-8
doi: 10.1016/j.annepidem.2023.10.003
pmc: PMC10842218
mid: NIHMS1940244
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
28-34Subventions
Organisme : NIMHD NIH HHS
ID : R01 MD016595
Pays : United States
Organisme : NIEHS NIH HHS
ID : R24 ES030894
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD034568
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES031259
Pays : United States
Organisme : NIH HHS
ID : UH3 OD023286
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK134981
Pays : United States
Organisme : NIGMS NIH HHS
ID : R25 GM143298
Pays : United States
Informations de copyright
Copyright © 2023 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Wei Perng, Marie-France Hivert, Andres Cardenas, and Anne Bozack report financial support was provided by National Institutes of Health. Zachary Laubach reports financial support was provided by National Science Foundation. Wei Perng reports financial support was provided by American Diabetes Association.
Références
Hum Mol Genet. 2013 Oct 15;22(R1):R7-R15
pubmed: 23918660
Clin Epigenetics. 2019 Apr 11;11(1):62
pubmed: 30975202
Perspect Psychol Sci. 2010 Sep;5(5):564-74
pubmed: 26162197
Semin Reprod Med. 2009 Sep;27(5):358-68
pubmed: 19711246
PLoS One. 2009 Aug 26;4(8):e6767
pubmed: 19774229
Aging (Albany NY). 2021 Dec 18;13(24):25653-25669
pubmed: 34923483
Epigenomics. 2019 Sep;11(12):1413-1427
pubmed: 31509016
J Health Soc Behav. 1990 Mar;31(1):43-57
pubmed: 2313076
Aging Cell. 2023 Feb;22(2):e13779
pubmed: 36650913
Int J Epidemiol. 2015 Feb;44(1):37-48
pubmed: 24639442
Dev Psychopathol. 2001 Summer;13(3):419-49
pubmed: 11523842
Chin Med J (Engl). 2021 Sep 14;134(24):2901-2910
pubmed: 34520417
Int Rev Neurobiol. 2020;150:107-128
pubmed: 32204828
Horm Behav. 2006 Nov;50(4):623-31
pubmed: 16914153
Clin Epigenetics. 2023 Apr 12;15(1):62
pubmed: 37046280
Nat Rev Genet. 2018 Jun;19(6):371-384
pubmed: 29643443
JAMA. 2021 Aug 17;326(7):621-627
pubmed: 34402850
Nat Rev Cardiol. 2009 Nov;6(11):712-22
pubmed: 19770848
Nature. 1977 Nov 24;270(5635):301-4
pubmed: 593350
Int J Environ Res Public Health. 2019 Aug 28;16(17):
pubmed: 31466396
Aging (Albany NY). 2019 Nov 22;11(22):10031-10051
pubmed: 31756171
Sci Rep. 2017 Aug 21;7(1):8962
pubmed: 28827677
EBioMedicine. 2017 Jul;21:29-36
pubmed: 28396265
Sci Rep. 2017 Nov 24;7(1):16266
pubmed: 29176660
Epigenetics. 2022 Jun;17(6):589-611
pubmed: 34227900
Environ Health Perspect. 2017 Apr;125(4):511-526
pubmed: 28362264
Ageing Res Rev. 2022 Jan;73:101536
pubmed: 34883202
Epidemiology. 2009 Jul;20(4):488-95
pubmed: 19525685
Environ Health Perspect. 2017 Aug 25;125(8):087019
pubmed: 28858830
Genome Biol. 2016 Aug 11;17(1):171
pubmed: 27511193
Biol Psychiatry. 2022 Feb 1;91(3):303-312
pubmed: 34756561
EBioMedicine. 2016 Feb 08;5:68-73
pubmed: 27077113
Proc Natl Acad Sci U S A. 2005 Jul 26;102(30):10604-9
pubmed: 16009939
Psychoneuroendocrinology. 2019 Jun;104:18-24
pubmed: 30784901
Genome Biol. 2016 Oct 7;17(1):207
pubmed: 27717397
Int J Mol Sci. 2020 Sep 29;21(19):
pubmed: 33003605
Sleep Health. 2020 Aug;6(4):463-468
pubmed: 32331867
Brain Behav Immun. 2022 Jul;103:28-36
pubmed: 35381348
Curr Environ Health Rep. 2018 Sep;5(3):317-327
pubmed: 30047075
Cell. 2005 Feb 25;120(4):437-47
pubmed: 15734677
Genome Biol. 2015 Jan 30;16:25
pubmed: 25633388
Aging (Albany NY). 2016 Sep 28;8(9):1844-1865
pubmed: 27690265
Epigenomics. 2021 Nov;13(21):1677-1699
pubmed: 33749330
J Am Acad Child Adolesc Psychiatry. 2018 May;57(5):321-328.e2
pubmed: 29706161
Clin Epigenetics. 2023 Sep 2;15(1):142
pubmed: 37660147
Dev Psychobiol. 2020 Mar;62(2):138-153
pubmed: 31724171
Trends Genet. 2007 Aug;23(8):413-8
pubmed: 17559965
JAMA. 2008 Jun 25;299(24):2877-83
pubmed: 18577732
Psychoneuroendocrinology. 2018 Nov;97:131-134
pubmed: 30016711
Proc Natl Acad Sci U S A. 2013 Aug 27;110(35):14138-43
pubmed: 23940324
Clin Genet. 2012 Apr;81(4):341-9
pubmed: 22236068
Soc Sci Med. 2005 Oct;61(7):1576-96
pubmed: 16005789
Genome Biol. 2019 Nov 25;20(1):249
pubmed: 31767039
Proc Biol Sci. 2021 Jan 27;288(1943):20202815
pubmed: 33499782
Clin Epigenetics. 2017 May 8;9:49
pubmed: 28503212
Radiol Clin North Am. 2008 Jul;46(4):643-52, v
pubmed: 18922285
Ageing Res Rev. 2021 Aug;69:101348
pubmed: 33930583
Epigenetics. 2011 Jun;6(6):692-702
pubmed: 21593595
JAMA. 2009 Jun 3;301(21):2252-9
pubmed: 19491187
Aging (Albany NY). 2018 Jul 26;10(7):1758-1775
pubmed: 30048243
Genome Biol. 2016 Sep 22;17(1):191
pubmed: 27654999
Genome Biol. 2013;14(10):R115
pubmed: 24138928
Curr Opin Behav Sci. 2016 Feb 1;7:40-46
pubmed: 26858971
Genome Biol. 2016 Oct 7;17(1):206
pubmed: 27717399
Evol Appl. 2008 Feb;1(1):28-48
pubmed: 25567489
JAMA Netw Open. 2020 Nov 2;3(11):e2024329
pubmed: 33146735