Lower muscle protein synthesis in humans with obesity concurrent with lower expression of muscle IGF1 splice variants.
Journal
Obesity (Silver Spring, Md.)
ISSN: 1930-739X
Titre abrégé: Obesity (Silver Spring)
Pays: United States
ID NLM: 101264860
Informations de publication
Date de publication:
11 2023
11 2023
Historique:
revised:
02
08
2023
received:
01
06
2023
accepted:
07
08
2023
pmc-release:
01
11
2024
medline:
23
10
2023
pubmed:
16
10
2023
entrez:
16
10
2023
Statut:
ppublish
Résumé
This study tested the hypothesis that expression of insulin-like growth factor 1 (IGF-1) protein and mRNA splice variants is lower in skeletal muscle of humans with obesity who have a lower mixed-muscle protein fractional synthesis rate (MMP-FSR) when compared with individuals without obesity. The study included nine participants with obesity (OB, mean [SD], BMI = 35 [3] kg/m Along with lower MMP-FSR, OB participants displayed lower mitochondrial protein FSR (p = 0.03) compared with W-OB participants. Expression of IGF-1 (p = 0.04) and IGF-1 receptor (p < 0.01) proteins was lower in muscle of OB participants. In addition, OB participants had lower (p < 0.05) mRNA expression of IGF1 variants Eb and Ec. This study demonstrates that lower protein synthesis in muscle of humans with obesity occurs concurrently with lower expression of muscle IGF-1 and IGF-1 receptor proteins, as well as lower mRNA expression of the IGF1 splice variants. These findings indicate that lower protein synthesis observed in muscle of humans with obesity may result from diminished muscle IGF1 gene expression.
Identifiants
pubmed: 37840435
doi: 10.1002/oby.23896
pmc: PMC10650963
mid: NIHMS1940175
doi:
Substances chimiques
Muscle Proteins
0
Insulin-Like Growth Factor I
67763-96-6
Receptor, IGF Type 1
EC 2.7.10.1
RNA, Messenger
0
Mitochondrial Proteins
0
IGF1 protein, human
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
2689-2698Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK123441
Pays : United States
Informations de copyright
© 2023 The Obesity Society.
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