Intima-media thickness at the near or far wall of the common carotid artery in cardiovascular risk assessment.
Cardiovascular risk
Common carotid artery intima-media thickness
Individual-participant-data meta-analysis
Journal
European heart journal open
ISSN: 2752-4191
Titre abrégé: Eur Heart J Open
Pays: England
ID NLM: 9918282081406676
Informations de publication
Date de publication:
Sep 2023
Sep 2023
Historique:
received:
28
03
2023
revised:
03
08
2023
accepted:
12
09
2023
medline:
16
10
2023
pubmed:
16
10
2023
entrez:
16
10
2023
Statut:
epublish
Résumé
Current guidelines recommend measuring carotid intima-media thickness (IMT) at the far wall of the common carotid artery (CCA). We aimed to precisely quantify associations of near vs. far wall CCA-IMT with the risk for atherosclerotic cardiovascular disease (CVD, defined as coronary heart disease or stroke) and their added predictive values. We analysed individual records of 41 941 participants from 16 prospective studies in the Proof-ATHERO consortium {mean age 61 years [standard deviation (SD) = 11]; 53% female; 16% prior CVD}. Mean baseline values of near and far wall CCA-IMT were 0.83 (SD = 0.28) and 0.82 (SD = 0.27) mm, differed by a mean of 0.02 mm (95% limits of agreement: -0.40 to 0.43), and were moderately correlated [ The associations of near and far wall CCA-IMT with incident CVD were positive, approximately linear, and similarly strong. Improvement in risk discrimination was highest when CCA-IMT was measured at both walls.
Identifiants
pubmed: 37840587
doi: 10.1093/ehjopen/oead089
pii: oead089
pmc: PMC10575622
doi:
Types de publication
Journal Article
Langues
eng
Pagination
oead089Informations de copyright
© The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology.
Déclaration de conflit d'intérêts
Conflict of interest: M.J.S. is a full-time employee of AstraZeneca. The other authors have reported that they have no relationships relevant to the contents of this paper to disclose.
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