Effects of Dextrose Supplementation on Chloral Hydrate Sedation: A Double-Blinded, Randomized, Prospective Study.
Chloral Hydrate
Dextrose
Sedation
Journal
Chonnam medical journal
ISSN: 2233-7385
Titre abrégé: Chonnam Med J
Pays: Korea (South)
ID NLM: 101564659
Informations de publication
Date de publication:
Sep 2023
Sep 2023
Historique:
received:
21
07
2023
revised:
10
08
2023
accepted:
29
08
2023
medline:
16
10
2023
pubmed:
16
10
2023
entrez:
16
10
2023
Statut:
ppublish
Résumé
Sedation plays a crucial role in successful pediatric imaging, and chloral hydrate is commonly used for this purpose. However, the challenges associated with chloral hydrate administration, such as its unpleasant taste and potential induction of vomiting, remain a concern. Sweet oral solutions have emerged as potential solutions for reducing distress and providing analgesia. This study compared the efficacy of dextrose combined with chloral hydrate with that of conventional sedation methods. This prospective, double-blind, randomized controlled clinical study enrolled 160 pediatric outpatients scheduled for echocardiography. Chloral hydrate syrup (100 mg/mL) was supplemented with a dextrose solution (dextrose group) or distilled water (control group) in a 1:10 volume ratio. The sedation achievement time, Skeie scale score, revised Face, Legs, Activity, Cry, and Consolability (FLACC) score, and side effects (nausea, vomiting, hypoxia, and respiratory depression) were assessed. No significant difference in average time to achieve sedation was observed between the dextrose and control groups (24.4±17.8 vs. 24.7±17.1 min, p=0.92). Both groups demonstrated similar levels of sedation according to the Skeie scale and mean revised FLACC score. Although the occurrence rates of nausea and vomiting had no significant differences, the dextrose group had no cases of vomiting in children aged >24 months compared to the control group, which had three cases (30%). In conclusion, the addition of dextrose to chloral hydrate did not significantly affect sedation time, anxiety, pain reduction, or occurrence of gastrointestinal complications during sedation.
Identifiants
pubmed: 37840674
doi: 10.4068/cmj.2023.59.3.174
pmc: PMC10570855
doi:
Types de publication
Journal Article
Langues
eng
Pagination
174-179Informations de copyright
© Chonnam Medical Journal, 2023.
Déclaration de conflit d'intérêts
CONFLICT OF INTEREST STATEMENT: None declared.
Références
J Pedod. 1977 Summer;1(4):272-80
pubmed: 270579
Paediatr Anaesth. 2001 Jul;11(4):453-8
pubmed: 11442864
Pain Res Manag. 2013 May-Jun;18(3):153-61
pubmed: 23748256
AJR Am J Roentgenol. 1995 Oct;165(4):905-9
pubmed: 7676990
Radiology. 2004 Feb;230(2):537-42
pubmed: 14699175
BMJ. 1999 Nov 27;319(7222):1393-7
pubmed: 10574854
Acta Anaesthesiol Scand. 1988 May;32(4):290-4
pubmed: 3134786
J Pain. 2000 Winter;1(4):275-8
pubmed: 14622610
AJR Am J Roentgenol. 1994 Jul;163(1):165-8
pubmed: 8010205
J Pediatr. 1996 Aug;129(2):287-91
pubmed: 8765629
J Pain. 2002 Jun;3(3):199-202
pubmed: 14622773
Arch Dis Child Fetal Neonatal Ed. 1999 Mar;80(2):F146-7
pubmed: 10325795
Chem Senses. 1994 Jun;19(3):239-49
pubmed: 7914461
Paediatr Anaesth. 2006 Mar;16(3):258-65
pubmed: 16490089
Pediatr Radiol. 2000 May;30(5):332-5
pubmed: 10836598
AJR Am J Roentgenol. 1993 Sep;161(3):639-41
pubmed: 8352124
J Am Assoc Lab Anim Sci. 2010 May;49(3):329-34
pubmed: 20587165
Pediatrics. 2002 Sep;110(3):523-8
pubmed: 12205254