Pathogenic variants in SMARCA1 cause an X-linked neurodevelopmental disorder modulated by NURF complex composition.

NURF complex SMARCA1 brain overgrowth epigenetics exome sequencing

Journal

Research square
Titre abrégé: Res Sq
Pays: United States
ID NLM: 101768035

Informations de publication

Date de publication:
29 Sep 2023
Historique:
medline: 16 10 2023
pubmed: 16 10 2023
entrez: 16 10 2023
Statut: epublish

Résumé

Pathogenic variants in ATP-dependent chromatin remodeling proteins are a recurrent cause of neurodevelopmental disorders (NDDs). The NURF complex consists of BPTF and either the SNF2H (

Identifiants

pubmed: 37841849
doi: 10.21203/rs.3.rs-3317938/v1
pmc: PMC10571636
pii:
doi:

Types de publication

Preprint

Langues

eng

Subventions

Organisme : NHGRI NIH HHS
ID : R01 HG009141
Pays : United States
Organisme : NIMH NIH HHS
ID : U01 MH119689
Pays : United States

Déclaration de conflit d'intérêts

KGM and MJGS are employees of GeneDX, LLC. All remaining authors declare no competing financial interests.

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Auteurs

David Picketts (D)

Ottawa Hospital Research Institute.

Ghayda Mirzaa (G)

Seattle Children's Hospital.

Keqin Yan (K)

Ottawa Hospital Research Institute.

Raissa Relator (R)

London Health Sciences Centre.

Sara Timpano (S)

Ottawa Hospital Research Institute.

Stephan Collins (S)

INSERM UMR-S 1231, University of Bourgogne Franche-Comté.

Alban Ziegler (A)

University Hospital of Angers.

Emily Pao (E)

Seattle Children's Research Institute.

Nora Oyama (N)

Seattle Children's Research Institute.

Elise Brischoux-Boucher (E)

Université de Franche-Comté.

Maria Guillen Sacoto (MG)

GeneDx, Gaithersburg, MD.

Kristen Park (K)

University of Colorado Denver School of Medicine.

Daniel Fernández-Mayoralas (D)

Hospital Universitario Quirónsalud.

Alberto Fernández-Jaén (A)

Department of Pediatrics and Neurology, Hospital Universitario Quirónsalud, School of Medicine, Universidad Europea de Madrid.

Parul Jayakar (P)

Division of Genetics and Metabolism, Nicklaus Children's Hospital.

Vincenzo Antona (V)

University of Palermo.

Elisa Giorgio (E)

University of Pavia.

Malin Kvarnung (M)

Karolinska Institutet.

Bertrand Isidor (B)

CHU de Nantes.

Solène Conrad (S)

Nantes Université.

Wallid Deb (W)

Nantes Université.

K E Stuurman (KE)

Department of Clinical Genetics, Erasmus University Medical Center.

Katalin Sterbova (K)

Charles University and Motol Hospital.

Noor Smal (N)

VIB Center for Molecular Neurology.

Sarah Weckhuysen (S)

VIB Center for Molecular Neurology.

Renske Oegema (R)

University Medical Center Utrecht.

Maeson Latsko (M)

The Steve and Cindy Rasmussen Institute for Genomic Medicine.

Tawfeg Ben-Omran (T)

Hamad Medical Corporation.

Rebecca Yeh (R)

Boston Children's Hospital.

Michael Kruer (M)

Phoenix Children's Hospital.

Somayeh Bakhtiari (S)

University of Arizona College of Medicine.

Antigone Papavasiliou (A)

IASO Children's Hospital.

Sébastien Moutton (S)

CHU François Mitterrand.

Sophie Nambot (S)

Centre de Génétique et Centre de référence «Anomalies du Développement et Syndromes Malformatifs», Hôpital d'Enfants, Centre Hospitalier.

Sirisak Chanprasert (S)

University of Washington.

Sarah Paolucci (S)

University of Washington.

Kait Miller (K)

University of Washington School of Medicine.

Barbara Burton (B)

Northwestern University Feinberg School of Medicine.

Katherine Kim (K)

Northwestern University Feinberg School of Medicine.

Emily O'Heir (E)

Broad Institute of MIT and Harvard.

Zandre Bruwer (Z)

University of Cape Town.

Kirsten Donald (K)

Division of Developmental Paediatrics, Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, Klipfontein Road/Private Bag, Rondebosch, 7700/7701, Cape Town, South A.

Tjitske Kleefstra (T)

Radboud University Medical Centre.

Amy Goldstein (A)

Children's Hospital of Pittsburgh of UPMC.

Brad Angle (B)

Advocate Children's Hospital.

Kelly Bontempo (K)

Advocate Children's Hospital.

Peter Miny (P)

University Hospital Basel.

Pascal Joset (P)

University Hospital Basel.

Florence Demurger (F)

Institute of Genetics & Development of Rennes.

Emma Hobson (E)

Leeds Teaching Hospitals Trust.

Lewis Pang (L)

Royal Devon and Exeter.

Lori Carpenter (L)

St Francis Health Systems.

Dong Li (D)

The Children's Hospital of Philadelphia.

Dominique Bonneau (D)

Department of Biochemistry and Genetics, University Hospital of Angers, F-49000.

Classifications MeSH