Nitric oxide, thyroglobulin, and calcitonin: unraveling the nature of thyroid nodules.

Humans Thyroid Nodule / diagnosis Thyroglobulin Thyroid Neoplasms / diagnosis Calcitonin Nitric Oxide Lymph Nodes / pathology Biomarkers
calcitonin fine needle aspiration biopsy nitric oxide thyroglobulin thyroid nodules

Journal

Frontiers in endocrinology
ISSN: 1664-2392
Titre abrégé: Front Endocrinol (Lausanne)
Pays: Switzerland
ID NLM: 101555782

Informations de publication

Date de publication:
2023
Historique:
received: 16 06 2023
accepted: 11 09 2023
medline: 23 10 2023
pubmed: 16 10 2023
entrez: 16 10 2023
Statut: epublish

Résumé

Thyroid nodules (TN) are localized morphological changes in the thyroid gland and can be benign or malignant. The present study investigates the relationships between biochemical markers in serum (s) and their homologs in washout (w) after fine-needle aspiration biopsy (FNAB) of the TN of interest and their correlation with cytology specimen findings. We investigated the relationships between serum biochemical markers nitric oxide (NO), thyroglobulin (TG), and calcitonin (CT), their homologs in washout after FNAB of the TN of interest, and cytology findings of biopsy samples classified according to the Bethesda system for thyroid cytopathology in this study, which included 86 subjects. Washout TG (TGw) level positively correlates with the cytology finding of the biopsy. A higher level of TGw correlates with higher categories of the Bethesda classification and indicates a higher malignant potential. The levels of serum NO (NOs), serum TG (TGs), serum CT (CTs), and washout CT (CTw) do not correlate with the cytology finding of the biopsy, and the higher levels of washout NO (NOw) correspond to the more suspicious ultrasound findings. The findings of our study suggest that TGw and NOw could be used as potential predictors of malignancy in TN.

Sections du résumé

Background
Thyroid nodules (TN) are localized morphological changes in the thyroid gland and can be benign or malignant.
Objective
The present study investigates the relationships between biochemical markers in serum (s) and their homologs in washout (w) after fine-needle aspiration biopsy (FNAB) of the TN of interest and their correlation with cytology specimen findings.
Methods
We investigated the relationships between serum biochemical markers nitric oxide (NO), thyroglobulin (TG), and calcitonin (CT), their homologs in washout after FNAB of the TN of interest, and cytology findings of biopsy samples classified according to the Bethesda system for thyroid cytopathology in this study, which included 86 subjects.
Results
Washout TG (TGw) level positively correlates with the cytology finding of the biopsy. A higher level of TGw correlates with higher categories of the Bethesda classification and indicates a higher malignant potential. The levels of serum NO (NOs), serum TG (TGs), serum CT (CTs), and washout CT (CTw) do not correlate with the cytology finding of the biopsy, and the higher levels of washout NO (NOw) correspond to the more suspicious ultrasound findings.
Conclusion
The findings of our study suggest that TGw and NOw could be used as potential predictors of malignancy in TN.

Identifiants

DOI: 10.3389/fendo.2023.1241223 PMID: 37842300 PMC: PMC10569474
pubmed: 37842300
doi: 10.3389/fendo.2023.1241223
pmc: PMC10569474
doi:

Substances chimiques

Thyroglobulin 9010-34-8
Calcitonin 9007-12-9
Nitric Oxide 31C4KY9ESH
Biomarkers 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1241223

Informations de copyright

Copyright © 2023 Samardzic, Macvanin, Zafirovic, Obradovic, Gluvic, Grubin, Gao, Essack and Isenovic.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Vladimir S Samardzic (VS)

Clinic for Internal Medicine, Department of Endocrinology and Diabetes, Zemun Clinical Hospital, School of Medicine, University of Belgrade, Belgrade, Serbia.

Mirjana T Macvanin (MT)

Department of Radiobiology and Molecular Genetics, VINČA Institute of Nuclear Sciences - National Institute of the Republic of Serbia, University of Belgrade, Belgrade, Serbia.

Sonja S Zafirovic (SS)

Department of Radiobiology and Molecular Genetics, VINČA Institute of Nuclear Sciences - National Institute of the Republic of Serbia, University of Belgrade, Belgrade, Serbia.

Milan M Obradovic (MM)

Department of Radiobiology and Molecular Genetics, VINČA Institute of Nuclear Sciences - National Institute of the Republic of Serbia, University of Belgrade, Belgrade, Serbia.

Zoran M Gluvic (ZM)

Clinic for Internal Medicine, Department of Endocrinology and Diabetes, Zemun Clinical Hospital, School of Medicine, University of Belgrade, Belgrade, Serbia.

Jasmina Grubin (J)

Ministry of Science, Technological Development and Innovation of the Republic of Serbia, Belgrade, Serbia.

Xin Gao (X)

Computational Bioscience Research Center (CBRC), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.
Computer Science Program, Computer, Electrical and Mathematical Sciences and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.

Magbubah Essack (M)

Computational Bioscience Research Center (CBRC), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.
Computer Science Program, Computer, Electrical and Mathematical Sciences and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.

Esma R Isenovic (ER)

Department of Radiobiology and Molecular Genetics, VINČA Institute of Nuclear Sciences - National Institute of the Republic of Serbia, University of Belgrade, Belgrade, Serbia.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Nitric oxide, thyroglobulin, and calcitonin:...
questionsmedicales.fr › Maladies endocriniennes › Maladies de la thyroïde › Tumeurs de la thyroïde › Nodule thyroïdien › Nitric oxide, thyroglobulin, and calcitonin:...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Iodoprotéines › Thyroglobuline › Nitric oxide, thyroglobulin, and calcitonin:...
questionsmedicales.fr › Maladies endocriniennes › Maladies de la thyroïde › Tumeurs de la thyroïde › Nitric oxide, thyroglobulin, and calcitonin:...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Neuropeptides › Calcitonine › Nitric oxide, thyroglobulin, and calcitonin:...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Oxydes › Oxydes d'azote › Monoxyde d'azote › Nitric oxide, thyroglobulin, and calcitonin:...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Système lymphatique › Tissu lymphoïde › Noeuds lymphatiques › Nitric oxide, thyroglobulin, and calcitonin:...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Nitric oxide, thyroglobulin, and calcitonin:...