Positive factors on survival of head and neck cancer of unknown primary: what the clinician can do.
CUP
cancer
cancer of unknown primary
hNCUP
hNSCC
head and neck
squamous cell carcinoma
survival
Journal
Acta oto-laryngologica
ISSN: 1651-2251
Titre abrégé: Acta Otolaryngol
Pays: England
ID NLM: 0370354
Informations de publication
Date de publication:
Sep 2023
Sep 2023
Historique:
medline:
9
11
2023
pubmed:
16
10
2023
entrez:
16
10
2023
Statut:
ppublish
Résumé
Management of patients with head and neck cancer of unknown primary (HNCUP) is challenging. To provide a long-term analysis focusing on protective survival factors for clinical decision-making. Furthermore, the prognostic value of the current N classification system was evaluated. We retrospectively analyzed patients with HNCUP between 2003 and 2016. Univariate and multivariate analyses were used to investigate predictors of overall survival (OS). A primary tumor was found in 67 of 290 patients with suspected HNCUP, leaving after exclusion 141 HNCUP cases for analysis, who received multi-step therapy (MST) ( Aspects for clinical decision-making: Curative MST and SCC histology were the most significant predictors for improved OS. Categorizing LN into 1, 2-3, and >3 LNs was more significant than the traditional N classification. The addition of CT to curative MST has a stronger impact on survival than HPV and N classifications.
Sections du résumé
BACKGROUND
UNASSIGNED
Management of patients with head and neck cancer of unknown primary (HNCUP) is challenging.
AIMS/OBJECTIVES
UNASSIGNED
To provide a long-term analysis focusing on protective survival factors for clinical decision-making. Furthermore, the prognostic value of the current N classification system was evaluated.
MATERIAL AND METHODS
UNASSIGNED
We retrospectively analyzed patients with HNCUP between 2003 and 2016. Univariate and multivariate analyses were used to investigate predictors of overall survival (OS).
RESULTS
UNASSIGNED
A primary tumor was found in 67 of 290 patients with suspected HNCUP, leaving after exclusion 141 HNCUP cases for analysis, who received multi-step therapy (MST) (
CONCLUSION AND SIGNIFICANCE
UNASSIGNED
Aspects for clinical decision-making: Curative MST and SCC histology were the most significant predictors for improved OS. Categorizing LN into 1, 2-3, and >3 LNs was more significant than the traditional N classification. The addition of CT to curative MST has a stronger impact on survival than HPV and N classifications.
Identifiants
pubmed: 37842931
doi: 10.1080/00016489.2023.2265937
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM