Emerging role of cyclophilin A in HIV-1 infection: from producer cell to the target cell nucleus.
capsid
cyclophilin A (CypA)
human immunodeficiency virus (HIV)
integration
reverse transcription nuclear entry
Journal
Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724
Informations de publication
Date de publication:
30 Nov 2023
30 Nov 2023
Historique:
medline:
1
12
2023
pubmed:
16
10
2023
entrez:
16
10
2023
Statut:
ppublish
Résumé
The HIV-1 genome encodes a small number of proteins with structural, enzymatic, regulatory, and accessory functions. These viral proteins interact with a number of host factors to promote the early and late stages of HIV-1 infection. During the early stages of infection, interactions between the viral proteins and host factors enable HIV-1 to enter the target cell, traverse the cytosol, dock at the nuclear pore, gain access to the nucleus, and integrate into the host genome. Similarly, the viral proteins recruit another set of host factors during the late stages of infection to orchestrate HIV-1 transcription, translation, assembly, and release of progeny virions. Among the host factors implicated in HIV-1 infection, Cyclophilin A (CypA) was identified as the first host factor to be packaged within HIV-1 particles. It is now well established that CypA promotes HIV-1 infection by directly binding to the viral capsid. Mechanistic models to pinpoint CypA's role have spanned from an effect in the producer cell to the early steps of infection in the target cell. In this review, we will describe our understanding of the role(s) of CypA in HIV-1 infection, highlight the current knowledge gaps, and discuss the potential role of this host factor in the post-nuclear entry steps of HIV-1 infection.
Identifiants
pubmed: 37843371
doi: 10.1128/jvi.00732-23
pmc: PMC10688351
doi:
Substances chimiques
Capsid Proteins
0
Cyclophilin A
EC 5.2.1.-
Viral Proteins
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0073223Subventions
Organisme : NIAID NIH HHS
ID : R01 AI136740
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI162694
Pays : United States
Organisme : NIAID NIH HHS
ID : R56 AI122960
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA057204
Pays : United States
Organisme : NIAID NIH HHS
ID : P30 AI117970
Pays : United States
Organisme : NIAID NIH HHS
ID : R25 AI164610
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI170228
Pays : United States
Organisme : NIMHD NIH HHS
ID : U54 MD007586
Pays : United States
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
Physiology (Bethesda). 2011 Aug;26(4):236-51
pubmed: 21841072
Nat Rev Microbiol. 2015 Aug;13(8):471-83
pubmed: 26179359
Transplantation. 1993 Jan;55(1):95-103
pubmed: 8420072
Nat Rev Microbiol. 2012 Mar 16;10(4):279-90
pubmed: 22421880
Cell. 1996 Dec 27;87(7):1285-94
pubmed: 8980234
FEBS Lett. 2001 Apr 20;495(1-2):1-6
pubmed: 11322937
J Virol. 1996 Jun;70(6):3551-60
pubmed: 8648689
Retrovirology. 2015 Jan 09;12:1
pubmed: 25571928
Blood. 1988 Dec;72(6):1904-10
pubmed: 2904290
Science. 1996 Jul 12;273(5272):231-5
pubmed: 8662505
Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14849-53
pubmed: 16203999
Cell Rep. 2020 Mar 17;30(11):3766-3777.e6
pubmed: 32187548
PLoS Pathog. 2013;9(10):e1003693
pubmed: 24130490
Cell Death Dis. 2013 Oct 31;4:e888
pubmed: 24176846
Proc Natl Acad Sci U S A. 1991 Nov 1;88(21):9483-7
pubmed: 1946361
Nature. 2013 Oct 24;502(7472):559-62
pubmed: 24048477
Cell Rep. 2019 Aug 27;28(9):2373-2385.e7
pubmed: 31422020
Trends Microbiol. 2017 Sep;25(9):741-755
pubmed: 28528781
Nature. 1994 Nov 24;372(6504):359-62
pubmed: 7969494
Antimicrob Agents Chemother. 2013 Oct;57(10):4622-31
pubmed: 23817385
Nature. 1984 Dec 20-1985 Jan 2;312(5996):763-7
pubmed: 6096719
J Biol Chem. 2016 May 27;291(22):11809-19
pubmed: 26994143
PLoS Pathog. 2014 Aug 07;10(8):e1004254
pubmed: 25101974
Proc Natl Acad Sci U S A. 2009 Jul 7;106(27):11090-5
pubmed: 19549863
Virology. 2000 Mar 15;268(2):294-307
pubmed: 10704338
J Virol. 2002 Jun;76(11):5667-77
pubmed: 11991995
Nat Microbiol. 2019 Nov;4(11):1840-1850
pubmed: 31611641
J Cell Sci. 2021 Feb 8;134(3):
pubmed: 33361281
Annu Rev Virol. 2017 Sep 29;4(1):309-325
pubmed: 28715971
Nature. 2010 Sep 9;467(7312):214-7
pubmed: 20829794
J Exp Med. 1998 Dec 7;188(11):2113-25
pubmed: 9841925
Cold Spring Harb Perspect Med. 2012 Aug 01;2(8):
pubmed: 22908191
J Virol. 1995 Apr;69(4):2451-61
pubmed: 7884893
Cell Host Microbe. 2018 Apr 11;23(4):536-548.e6
pubmed: 29649444
J Biol Chem. 1992 Jun 15;267(17):11968-71
pubmed: 1601866
Viruses. 2018 Nov 15;10(11):
pubmed: 30445742
Nat Med. 2005 Dec;11(12):1287-9
pubmed: 16311605
Cold Spring Harb Perspect Med. 2012 Feb;2(2):a006916
pubmed: 22355797
Cell Host Microbe. 2010 Mar 18;7(3):221-33
pubmed: 20227665
Science. 2020 Oct 9;370(6513):
pubmed: 33033190
Cold Spring Harb Perspect Med. 2012 Jul;2(7):a006890
pubmed: 22762018
Proc Natl Acad Sci U S A. 2011 Jun 14;108(24):9975-80
pubmed: 21628558
Nature. 2018 Aug;560(7719):509-512
pubmed: 30069050
J Virol. 2016 May 27;90(12):5808-5823
pubmed: 27076642
PLoS Pathog. 2014 Oct 30;10(10):e1004459
pubmed: 25356722
Antiviral Res. 2010 Jan;85(1):119-41
pubmed: 19782103
J Biol Chem. 2010 Dec 10;285(50):39314-28
pubmed: 20937817
Nat Rev Microbiol. 2014 Aug;12(8):563-74
pubmed: 25029025
J Virol. 2005 Jan;79(1):176-83
pubmed: 15596813
J Virol. 2001 Oct;75(19):9357-66
pubmed: 11533199
Immunity. 2018 Aug 21;49(2):235-246.e4
pubmed: 30076100
Viruses. 2020 Oct 30;12(11):
pubmed: 33143125
Proc Natl Acad Sci U S A. 1992 Sep 1;89(17):8351-5
pubmed: 1381509
Virus Res. 2012 Nov;169(2):388-410
pubmed: 22728445
Cell Host Microbe. 2008 Nov 13;4(5):495-504
pubmed: 18976975
Nat Microbiol. 2021 Apr;6(4):435-444
pubmed: 33649557
J Virol. 2004 Jun;78(11):5670-8
pubmed: 15140964
Nature. 2020 Aug;584(7822):614-618
pubmed: 32612233
Nat Microbiol. 2019 Dec;4(12):2044-2051
pubmed: 31636416
Eukaryot Cell. 2005 Jan;4(1):17-29
pubmed: 15643056
Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):E1054-63
pubmed: 26858452
Proc Natl Acad Sci U S A. 2012 May 29;109(22):8564-9
pubmed: 22586087
J Cell Sci. 2009 Apr 15;122(Pt 8):1100-10
pubmed: 19299463
Biochem Biophys Res Commun. 2012 Aug 10;424(4):647-50
pubmed: 22814107
Appl Microbiol Biotechnol. 2021 Feb;105(4):1365-1377
pubmed: 33492451
Annu Rev Virol. 2022 Sep 29;9(1):261-284
pubmed: 35704745
PLoS Pathog. 2017 Aug 21;13(8):e1006570
pubmed: 28827840
C R Acad Sci III. 1986;303(9):343-8
pubmed: 3096516
Cell Mol Life Sci. 2008 May;65(9):1403-24
pubmed: 18264802
J Virol. 2018 Sep 12;92(19):
pubmed: 29997211
PLoS Pathog. 2010 Dec 09;6(12):e1001220
pubmed: 21170360
Immunol Rev. 2017 Jan;275(1):161-182
pubmed: 28133806
Retrovirology. 2021 Oct 26;18(1):32
pubmed: 34702294
PLoS One. 2012;7(9):e46037
pubmed: 23049930
Retrovirology. 2011 Dec 16;8:104
pubmed: 22176773
Viruses. 2021 Jan 18;13(1):
pubmed: 33477441
PLoS One. 2017 Aug 2;12(8):e0182298
pubmed: 28767697
Cell Cycle. 2012 Apr 1;11(7):1340-53
pubmed: 22421161
EMBO J. 2007 Jun 20;26(12):3025-37
pubmed: 17557080
Annu Rev Biophys Biomol Struct. 1993;22:123-42
pubmed: 7688608
Retrovirology. 2018 Jan 12;15(1):5
pubmed: 29329553
Science. 2008 Feb 15;319(5865):921-6
pubmed: 18187620
mBio. 2020 Dec 1;11(6):
pubmed: 33262260
Proc Natl Acad Sci U S A. 1998 Feb 17;95(4):1758-63
pubmed: 9465090
J Virol. 2005 Dec;79(24):15567-72
pubmed: 16306627
J Virol. 1998 Jan;72(1):303-8
pubmed: 9420228
Nat Med. 2003 Sep;9(9):1138-43
pubmed: 12897779
Nature. 2017 Jul 20;547(7663):360-363
pubmed: 28700571
J Autoimmun. 1992 Apr;5 Suppl A:67-72
pubmed: 1380246
J Virol. 2010 Jan;84(1):397-406
pubmed: 19846519
Helv Chim Acta. 1976;59(4):1075-92
pubmed: 950308
Nature. 1998 Jun 18;393(6686):648-59
pubmed: 9641677
Nat Commun. 2016 Mar 04;7:10714
pubmed: 26940118
Adv Exp Med Biol. 2012;726:441-65
pubmed: 22297526
J Biol Chem. 2005 Jul 8;280(27):25517-23
pubmed: 15855167
J Virol. 2013 Jan;87(1):422-32
pubmed: 23097435
J Virol. 2007 Nov;81(21):11946-56
pubmed: 17715216
Nat Protoc. 2019 Jan;14(1):1-27
pubmed: 30559373
Retrovirology. 2006 Oct 12;3:70
pubmed: 17038183
Cell Rep. 2020 Sep 29;32(13):108201
pubmed: 32997983
Cell Mol Life Sci. 1999 Mar;55(3):423-36
pubmed: 10228556
Proc Natl Acad Sci U S A. 2020 Mar 10;117(10):5486-5493
pubmed: 32094182
Proc Natl Acad Sci U S A. 2002 Apr 16;99(8):5247-52
pubmed: 11929983
Proc Natl Acad Sci U S A. 2001 May 22;98(11):6360-5
pubmed: 11353871
J Virol. 2019 Mar 5;93(6):
pubmed: 30567984
Immunol Today. 1992 Apr;13(4):136-42
pubmed: 1374612
Nature. 2008 Sep 4;455(7209):109-13
pubmed: 18668044
Science. 2020 Oct 16;370(6514):360-364
pubmed: 33060363
Nature. 1987 Sep 17-23;329(6136):268-70
pubmed: 3306408
Nat Med. 2019 Sep;25(9):1377-1384
pubmed: 31501601
Elife. 2020 Jun 17;9:
pubmed: 32553106
Nat Microbiol. 2020 Sep;5(9):1088-1095
pubmed: 32483230
J Virol. 1997 Aug;71(8):5871-7
pubmed: 9223476
Annu Rev Biochem. 2019 Jun 20;88:725-783
pubmed: 30883195
Cytogenet Cell Genet. 1996;74(4):262
pubmed: 8976380
J Virol. 2011 Aug;85(15):7818-27
pubmed: 21593146
Virology. 2013 May 25;440(1):8-18
pubmed: 23523133
PLoS Pathog. 2011 Mar;7(3):e1001313
pubmed: 21423673
Retrovirology. 2014 Jan 30;11:11
pubmed: 24479545
Nat Rev Microbiol. 2017 Feb;15(2):69-82
pubmed: 27941817
J Virol. 2011 Dec;85(24):12950-61
pubmed: 21976643
J Gen Virol. 2007 Jan;88(Pt 1):207-216
pubmed: 17170453
J Virol. 2023 Apr 27;97(4):e0027823
pubmed: 37129415
J Virol. 2015 Jan;89(1):643-51
pubmed: 25339776
Nucleic Acids Res. 2021 Jan 25;49(2):621-635
pubmed: 33337475
J Virol. 2013 Jan;87(1):648-58
pubmed: 23097450
CMAJ. 1989 Jun 15;140(12):1456-60
pubmed: 2720530
J Mol Biol. 1997 Jun 27;269(5):780-95
pubmed: 9223641
Cell. 2009 Nov 13;139(4):780-90
pubmed: 19914170
PLoS Pathog. 2021 Dec 30;17(12):e1010109
pubmed: 34968390
Curr Top Med Chem. 2003;3(12):1315-47
pubmed: 12871165
J Mol Biol. 2013 Apr 26;425(8):1318-29
pubmed: 23353830
PLoS Pathog. 2016 Jun 21;12(6):e1005700
pubmed: 27327622
J Virol. 1996 Jul;70(7):4220-7
pubmed: 8676442
Retrovirology. 2013 Feb 15;10:20
pubmed: 23414560
J Virol. 2018 Sep 26;92(20):
pubmed: 30068656
Proc Natl Acad Sci U S A. 1992 Apr 15;89(8):3511-5
pubmed: 1565646
Virus Res. 2012 Dec;170(1-2):15-24
pubmed: 23041358
AIDS Res. 1986 Summer;2(3):163-74
pubmed: 3489470
Cold Spring Harb Perspect Med. 2012 Oct 01;2(10):
pubmed: 23028129
Annu Rev Biochem. 1998;67:1-25
pubmed: 9759480
Nature. 2013 Oct 24;502(7472):563-6
pubmed: 24121441
mBio. 2016 Oct 25;7(5):
pubmed: 27795397
J Cell Biol. 2002 Nov 11;159(3):441-52
pubmed: 12417576
J Virol. 2009 Aug;83(15):7524-35
pubmed: 19457995
Cold Spring Harb Perspect Med. 2012 Jul;2(7):a006924
pubmed: 22762019
Antimicrob Agents Chemother. 1994 Aug;38(8):1763-72
pubmed: 7527198
Science. 1984 Nov 2;226(4674):544-7
pubmed: 6238408
Nature. 2013 May 30;497(7451):643-6
pubmed: 23719463
Methods. 2009 Apr;47(4):291-7
pubmed: 19232540
J Virol. 2011 Jan;85(1):542-9
pubmed: 20962083
Dev Cell. 2015 Jun 22;33(6):717-28
pubmed: 26051542
Retrovirology. 2013 Mar 06;10:29
pubmed: 23497318
Virology. 1999 Apr 25;257(1):261-74
pubmed: 10208939
PLoS Pathog. 2011 Dec;7(12):e1002439
pubmed: 22174692
Cell. 1993 Jun 18;73(6):1067-78
pubmed: 8513493
EMBO J. 2021 Jan 4;40(1):e105247
pubmed: 33270250
Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2728-33
pubmed: 24449914
J Immunol. 1986 Aug 1;137(3):1054-9
pubmed: 3522735
PLoS Pathog. 2007 Oct 26;3(10):1502-10
pubmed: 17967060
Protein Sci. 1997 Nov;6(11):2297-307
pubmed: 9385632
Proc Natl Acad Sci U S A. 2017 Dec 12;114(50):E10707-E10716
pubmed: 29180435
Cell. 2008 Oct 3;135(1):49-60
pubmed: 18854154
J Virol. 2006 Apr;80(8):3712-20
pubmed: 16571788
Semin Cell Dev Biol. 2017 Aug;68:42-51
pubmed: 28506890
Front Biosci. 2004 Sep 01;9:2285-96
pubmed: 15353287
Cell Host Microbe. 2013 Oct 16;14(4):398-410
pubmed: 24055605
Retrovirology. 2013 Jul 31;10:81
pubmed: 23902822
J Virol. 2009 Feb;83(4):2044-7
pubmed: 19073742
PLoS Pathog. 2021 Sep 20;17(9):e1009484
pubmed: 34543344
J Virol. 2004 Dec;78(23):12800-8
pubmed: 15542632
EMBO J. 2001 Mar 15;20(6):1300-9
pubmed: 11250896
Biomed Biochim Acta. 1984;43(10):1101-11
pubmed: 6395866
J Virol. 1998 Aug;72(8):6430-6
pubmed: 9658084
Nature. 1984 Dec 20-1985 Jan 2;312(5996):767-8
pubmed: 6083454
PNAS Nexus. 2022 May 20;1(2):pgac064
pubmed: 35719891
J Biol Chem. 1992 Jul 5;267(19):13115-8
pubmed: 1618811
Science. 2014 Nov 7;346(6210):759-63
pubmed: 25298114
Annu Rev Biochem. 2007;76:647-71
pubmed: 17506639
Nat Rev Microbiol. 2015 Aug;13(8):484-96
pubmed: 26119571
Retrovirology. 2019 Apr 4;16(1):10
pubmed: 30947724
Nature. 2006 Jun 15;441(7095):847-52
pubmed: 16728975
J Virol. 1995 Feb;69(2):814-24
pubmed: 7815548
Cell Host Microbe. 2018 Sep 12;24(3):392-404.e8
pubmed: 30173955
Nature. 2009 Aug 6;460(7256):711-6
pubmed: 19661910
Nat Methods. 2006 Oct;3(10):817-24
pubmed: 16990814
Curr Biol. 2008 Aug 26;18(16):1192-202
pubmed: 18722123
mBio. 2021 Mar 23;12(2):
pubmed: 33758083
EMBO J. 1999 Dec 1;18(23):6771-85
pubmed: 10581250
Immunol Rev. 2017 Jan;275(1):21-32
pubmed: 28133813
Structure. 2019 Aug 6;27(8):1234-1245.e5
pubmed: 31155311
Nat Commun. 2015 Mar 30;6:6660
pubmed: 25818806
Cell Mol Life Sci. 2018 Jul;75(14):2491-2507
pubmed: 29417178
Elife. 2018 Aug 07;7:
pubmed: 30084827
Elife. 2018 May 31;7:
pubmed: 29848441
Elife. 2019 Jan 23;8:
pubmed: 30672737
Methods Mol Biol. 2014;1087:37-46
pubmed: 24158812
Nature. 1994 Nov 24;372(6504):363-5
pubmed: 7969495
Antimicrob Agents Chemother. 2008 Apr;52(4):1302-17
pubmed: 18212100
J Virol. 1996 Jul;70(7):4299-310
pubmed: 8676452
Retrovirology. 2009 Mar 02;6:21
pubmed: 19254360
Int Arch Allergy Immunol. 1992;98(4):293-8
pubmed: 1384862
Eur J Biochem. 1990 Jul 5;190(3):477-82
pubmed: 2197089
PLoS Pathog. 2021 Jan 21;17(1):e1009190
pubmed: 33476323
Elife. 2021 Apr 27;10:
pubmed: 33904396
Trends Cell Biol. 1992 Sep;2(9):272-6
pubmed: 14731520