Parietal resting-state EEG alpha source connectivity is associated with subcortical white matter lesions in HIV-positive people.
Human immunodeficiency virus (HIV)
Low-resolution brain electromagnetic source tomography (LORETA)
Magnetic resonance imaging (MRI)
Resting state EEG rhythms
Journal
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
ISSN: 1872-8952
Titre abrégé: Clin Neurophysiol
Pays: Netherlands
ID NLM: 100883319
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
received:
25
02
2020
revised:
07
08
2023
accepted:
21
09
2023
pubmed:
17
10
2023
medline:
17
10
2023
entrez:
16
10
2023
Statut:
ppublish
Résumé
Parietal resting-state electroencephalographic (rsEEG) alpha (8-10 Hz) source connectivity is abnormal in HIV-positive persons. Here we tested whether this abnormality may be associated with subcortical white matter vascular lesions in the cerebral hemispheres. Clinical, rsEEG, and magnetic resonance imaging (MRI) datasets in 38 HIV-positive persons and clinical and rsEEG datasets in 13 healthy controls were analyzed. Radiologists visually evaluated the subcortical white matter hyperintensities from T2-weighted FLAIR MRIs (i.e., Fazekas scale). In parallel, neurophysiologists estimated the eLORETA rsEEG source lagged linear connectivity from parietal cortical regions of interest. Compared to the HIV participants with no/negligible subcortical white matter hyperintensities, the HIV participants with mild/moderate subcortical white matter hyperintensities showed lower parietal interhemispheric rsEEG alpha lagged linear connectivity. This effect was also observed in HIV-positive persons with unimpaired cognition. This rsEEG marker allowed good discrimination (area under the receiver operating characteristic curve > 0.80) between the HIV-positive individuals with different amounts of subcortical white matter hyperintensities. The parietal rsEEG alpha source connectivity is associated with subcortical white matter vascular lesions in HIV-positive persons, even without neurocognitive disorders. Those MRI-rsEEG markers may be used to screen HIV-positive persons at risk of neurocognitive disorders.
Identifiants
pubmed: 37844524
pii: S1388-2457(23)00733-2
doi: 10.1016/j.clinph.2023.09.006
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
19-27Informations de copyright
Copyright © 2023 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.