68 Ga-DOTATATE PET/CT of Metastatic Lymphoepithelial Carcinoma of Parotid Gland.


Journal

Clinical nuclear medicine
ISSN: 1536-0229
Titre abrégé: Clin Nucl Med
Pays: United States
ID NLM: 7611109

Informations de publication

Date de publication:
01 Dec 2023
Historique:
medline: 8 11 2023
pubmed: 17 10 2023
entrez: 16 10 2023
Statut: ppublish

Résumé

We present a case of a 59-year-old woman with lymphoepithelial carcinoma of left parotid gland. She was treated with radical radiotherapy, but her plasma Epstein-Barr virus DNA load continued to increase despite good locoregional response. As her primary tumor was positive for somatostatin receptor type 2, we performed 68 Ga-DOTATATE PET/CT, which revealed multiple DOTATATE-avid distant metastases.

Identifiants

pubmed: 37844551
doi: 10.1097/RLU.0000000000004899
pii: 00003072-990000000-00754
doi:

Substances chimiques

copper dotatate CU-64 0
Gallium-68 98B30EPP5S
Organometallic Compounds 0

Types de publication

Case Reports Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1056-1058

Informations de copyright

Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.

Déclaration de conflit d'intérêts

Conflicts of interest and sources of funding: none declared. This study received funding from National Cancer Centre Singapore Research Fund.

Références

Thompson LDR, Whaley RD. Lymphoepithelial carcinoma of salivary glands. Surg Pathol Clin . 2021;14:75–96.
Zhao W, Deng N, Gao X, et al. Primary lymphoepithelioma-like carcinoma of salivary glands: a clinicopathological study of 21 cases. Int J Clin Exp Pathol . 2014;7:7951–7956.
Lechner M, Schartinger VH, Steele CD, et al. Somatostatin receptor 2 expression in nasopharyngeal cancer is induced by Epstein Barr virus infection: impact on prognosis, imaging and therapy. Nat Commun . 2021;12:117.
Khor LK, Loi HY, Sinha AK, et al. (68)Ga-DOTA-peptide: a novel molecular biomarker for nasopharyngeal carcinoma. Head Neck . 2016;38:E76–E80.
Zhao L, Pang Y, Wang Y, et al. Somatostatin receptor imaging with [ 68 Ga]Ga-DOTATATE positron emission tomography/computed tomography (PET/CT) in patients with nasopharyngeal carcinoma. Eur J Nucl Med Mol Imaging . 2022;49:1360–1373.
Shang Q, Pang Y, Meng T, et al. 68 Ga-DOTATATE PET/CT in primary pulmonary lymphoepithelioma-like carcinoma. Clin Nucl Med . 2022;47:187–189.
Tao L, Chen Y, Huang Y, et al. SSTR2a is constantly expressed in lymphoepithelioma-like carcinoma with squamous differentiation other than that with glandular differentiation. J Clin Pathol . 2021;74:704–708.
Punjabi LS, Daryl Seow MK, Ahmed SS. Lymphoepithelial carcinoma of the salivary gland—a great cytologic mimicker in the head and neck region, and the first report of SSTR2 expression on cytologic material. Diagn Cytopathol . 2022;50:525–528.

Auteurs

Han Chung Low (HC)

From the Department of Nuclear Medicine and Molecular Imaging, Singapore General Hospital.

Kelvin Siu Hoong Loke (KSH)

From the Department of Nuclear Medicine and Molecular Imaging, Singapore General Hospital.

Fu Qiang Wang (FQ)

Divisions of Radiation Oncology.

Shuting Han (S)

Medical Oncology, National Cancer Centre Singapore, Singapore.

Wen Long Nei (WL)

Divisions of Radiation Oncology.

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Classifications MeSH