Prognostic value of the combined effect of nutritional status and body water component in patients with colorectal cancer.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
16 10 2023
16 10 2023
Historique:
received:
09
06
2023
accepted:
27
09
2023
medline:
23
10
2023
pubmed:
17
10
2023
entrez:
16
10
2023
Statut:
epublish
Résumé
The aim of this study was to explore the impact of Geriatric Nutritional Risk Index (GNRI) and body water component (BWC) on the survival of colorectal cancer (CRC) patients and whether the combined effect had a potential prognostic and predictive efficacy. We evaluated the accuracy of GNRI for malnutrition and estimated the predictive capacity of BWC for survival. Kaplan-Meier survival curves and cox regression analyses were used to examine the prognostic effects. A nutrition-water score (NWS) model was developed and evaluated the survival predictive power. GNRI and extracellular water-to-intracellular water ratio (ECW/ICW) were integrated, with the cut-off values of 103.5 and 63.7%. Lower GNRI and higher ECW/ICW were independent risk factors for poor prognosis in CRC patients. The combination of the two into the NWS model demonstrated a higher risk of death for patients with NWS ≥ 1 compared to those with NWS of 0. NWS showed a better predictive capability compared to GNRI and ECW/ICW, with the concordance index of 0.681. Our study demonstrates GNRI and ECW/ICW's prognostic utility in CRC, with their combination improving survival prediction to help guide patient-centered treatment.
Identifiants
pubmed: 37845294
doi: 10.1038/s41598-023-43736-0
pii: 10.1038/s41598-023-43736-0
pmc: PMC10579348
doi:
Substances chimiques
Water
059QF0KO0R
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
17570Informations de copyright
© 2023. Springer Nature Limited.
Références
PLoS One. 2017 Jan 18;12(1):e0170272
pubmed: 28099511
Am J Clin Nutr. 2005 Oct;82(4):777-83
pubmed: 16210706
Cancer Manag Res. 2021 Apr 09;13:3133-3143
pubmed: 33859499
Anticancer Res. 2017 Jan;37(1):197-202
pubmed: 28011491
Obes Rev. 2008 Mar;9 Suppl 1:14-21
pubmed: 18307694
JPEN J Parenter Enteral Nutr. 2023 Mar;47(3):408-419
pubmed: 36587281
Clin Nutr. 2021 Jun;40(6):4225-4233
pubmed: 33579553
Nutrients. 2019 Aug 09;11(8):
pubmed: 31405072
JPEN J Parenter Enteral Nutr. 2023 Mar;47(3):420-428
pubmed: 36645343
Front Nutr. 2022 Nov 15;9:1061944
pubmed: 36458177
J Nutr Health Aging. 2019;23(1):96-101
pubmed: 30569076
Clin Nutr. 2019 Apr;38(2):644-651
pubmed: 29789167
Front Nutr. 2022 Dec 15;9:1060224
pubmed: 36590205
Sci Rep. 2021 Apr 27;11(1):9038
pubmed: 33907232
Ann Ital Chir. 2023;94:73-81
pubmed: 36810299
Osteoporos Int. 2010 Apr;21(4):543-59
pubmed: 19779761
Nutrients. 2019 Mar 19;11(3):
pubmed: 30893821
CA Cancer J Clin. 2021 May;71(3):209-249
pubmed: 33538338
Acupunct Med. 2020 Feb;38(1):53-60
pubmed: 31544469
Clin Nutr. 2021 Mar;40(3):1224-1232
pubmed: 32826109
Curr Opin Clin Nutr Metab Care. 2003 Mar;6(2):211-6
pubmed: 12589191
Nutr Cancer. 2022;74(1):168-174
pubmed: 33570437
Int J Inflam. 2020 May 20;2020:3254017
pubmed: 32518615
Front Nutr. 2022 Jun 21;9:920714
pubmed: 35799588
PLoS One. 2020 Dec 15;15(12):e0241305
pubmed: 33320857
BMJ Open. 2017 Nov 12;7(11):e018443
pubmed: 29133331
Clin Nutr. 2014 Oct;33(5):737-48
pubmed: 24785098
Arch Biochem Biophys. 2007 Jun 15;462(2):176-88
pubmed: 17321483
J Clin Med. 2020 Nov 10;9(11):
pubmed: 33182670
J Nutr Health Aging. 2015 Dec;19(10):986-93
pubmed: 26624209
Support Care Cancer. 2022 Oct;30(10):7845-7852
pubmed: 35716261
Cancer Med. 2018 Aug;7(8):3695-3703
pubmed: 29971962
Front Oncol. 2022 Nov 23;12:1066417
pubmed: 36518324
Eur J Appl Physiol. 2017 Oct;117(10):2001-2007
pubmed: 28755131
Front Oncol. 2022 Oct 24;12:896160
pubmed: 36353554
Blood Purif. 2007;25(3):260-6
pubmed: 17429200