Do autologous platelet concentrates (APCs) have a role in intra-oral bone regeneration? A critical review of clinical guidelines on decision-making process.
APCs
ARP
GBR
GTR
L-PRF
PRGF
PRP
alveolar ridge preservation
autologous platelet concentrates
guided bone regeneration
guided tissue regeneration
intra-bony defects
lateral window technique
leukocyte- and platelet-rich fibrin
plasma rich in growth factor
platelet-rich plasma
sinus floor elevation
transcrestal technique
Journal
Periodontology 2000
ISSN: 1600-0757
Titre abrégé: Periodontol 2000
Pays: Denmark
ID NLM: 9313276
Informations de publication
Date de publication:
16 Oct 2023
16 Oct 2023
Historique:
revised:
05
07
2023
received:
22
07
2022
accepted:
15
08
2023
medline:
17
10
2023
pubmed:
17
10
2023
entrez:
17
10
2023
Statut:
aheadofprint
Résumé
In the past decades, personalized regenerative medicine has gained increased attention. Autologous platelet concentrates (APCs) such as PRP, PRGF, and L-PRF, all serving as a source of a large variety of cells and growth factors that participate in hard and soft tissue healing and regeneration, could play a significant role in regenerative periodontal procedures. This narrative review evaluated the relative impact of APCs in alveolar ridge preservation, sinus floor augmentation, and the regeneration of bony craters around teeth, both as a single substitute or in combination with a xenograft. L-PRF has a significant beneficial effect on alveolar ridge preservation (<alveolar bone resorption, >bone quality). The data for PRGF are less convincing, and PRP is controversial. L-PRF can successfully be used as a single substitute during transcrestal (≥3.5 mm bone gain) as well as 1-stage lateral window sinus floor elevation (>5 mm bone gain). For PRGF and especially PRP the data are very scarce. In the treatment of bony craters around teeth, during open flap debridement, L-PRF as a single substitute showed significant adjunctive benefits (e.g., >PPD reduction, >CAL gain, >crater depth reduction). The data for PRP and PRGF were non-conclusive. Adding PRP or L-PRF to a xenograft during OFD resulted in additional improvements (>PPD reduction, >CAL gain, >bone fill), for PRGF no data were found. Autologous platelet concentrates demonstrated to enhance bone and soft tissue healing in periodontal regenerative procedures. The data for L-PRF were most convincing. L-PRF also has the advantage of a greater simplicity of production, and its 100% autologous character.
Types de publication
Journal Article
Review
Langues
eng
Informations de copyright
© 2023 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Références
Yung YL, Fu SC, Cheuk YC, et al. Optimisation of platelet concentrates therapy: composition, localisation, and duration of action. Asia Pac J Sports Med Arthrosc Rehabil Technol. 2017;7:27-36.
Dohan Ehrenfest DM, Rasmusson L, Albrektsson T. Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyte- and platelet- rich fibrin (L-PRF). Trends Biotechnol. 2009;27(3):158-167.
Dohan Ehrenfest DM, Andia I, Zumstein MA, Zhang CQ, Pinto NR, Bielecki T. Classification of platelet concentrates (platelet-rich plasma-PRP, platelet-rich fibrin-PRF) for topical and infiltrative use in orthopedic and sports medicine: current consensus, clinical implications and perspectives. Muscles Ligaments Tendons J. 2014;4(1):3-9.
Varshney S, Dwivedi A, Pandey V. Antimicrobial effects of various platelet rich concentrates-vibes from in-vitro studies-a systematic review. J Oral Biol Craniofac Res. 2019;9(4):299-305.
Pietruszka P, Chruścicka I, Duś-Ilnicka I, Paradowska-Stolarz A. PRP and PRF-subgroups and divisions when used in dentistry. J Pers Med. 2021;11(10):944.
Oudelaar BW, Peerbooms JC, Huis In't Veld R, Vochteloo AJH. Concentrations of blood components in commercial platelet-rich plasma separation systems: a review of the literature. Am J Sports Med. 2019;47(2):479-487.
Whitman DH, Berry RL, Green DM. Platelet gel: an autologous alternative to fibrin glue with applications in oral and maxillofacial surgery. J Oral Maxillofac Surg. 1997;55(11):1294-1299.
Marx RE, Carlson ER, Eichstaedt RM, Schimmele SR, Strauss JE, Georgeff KR. Platelet-rich plasma: growth factor enhancement for bone grafts. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998;85(6):638-646.
Anitua E. Plasma rich in growth factors: preliminary results of use in the preparation of future sites for implants. Int J Oral Maxillofac Implants. 1999;14(4):529-535.
Anitua E, Sánchez M, Orive G, Andía I. The potential impact of the preparation rich in growth factors (PRGF) in different medical fields. Biomaterials. 2007;28(31):4551-4560.
Giusto G, Vercelli C, Iussich S, Tursi M, Perona G, Gandini M. Comparison of the effects of platelet-rich or growth factor-rich plasma on intestinal anastomosis healing in pigs. BMC Vet Res. 2017;13(1):188.
Nishiyama K, Okudera T, Watanabe T, et al. Basic characteristics of plasma rich in growth factors (PRGF): blood cell components and biological effects. Clin Exp Dent Res. 2016;2(2):96-103.
Giannini S, Cielo A, Bonanome L, et al. Comparison between PRP, PRGF and PRF: lights and shadows in three similar but different protocols. Eur Rev Med Pharmacol Sci. 2015;19(6):927-930.
Dohan Ehrenfest DM, Del Corso M, Diss A, Mouhyi J, Charrier JB. Three- dimensional architecture and cell composition of a Choukroun's platelet-rich fibrin clot and membrane. J Periodontol. 2010;81(4):546-555.
Anitua E, Alkhraisat MH, Orive G. Perspectives and challenges in regenerative medicine using plasma rich in growth factors. J Control Release. 2012;157(1):29-38.
Li Q, Pan S, Dangaria SJ, et al. Platelet-rich fibrin promotes periodontal regeneration and enhances alveolar bone augmentation. Biomed Res Int. 2013;2013:638043.
Castro AB, Andrade C, Li X, Pinto N, Teughels W, Quirynen M. Impact of g force and timing on the characteristics of platelet-rich fibrin matrices. Sci Rep. 2021;11(1):6038.
Yu S, Wang Y, Miron RJ, Zhang Y. Structure, barrier function, and bioactivity of platelet-rich fibrin following thermal processing. Tissue Eng Part C Methods. 2021;27(11):605-615.
Ratajczak J, Vangansewinkel T, Gervois P, et al. Angiogenic properties of ‘Leukocyte- and platelet-rich Fibrin’. Sci Rep. 2018;8(1):14632.
Castro AB, Herrero ER, Slomka V, Pinto N, Teughels W, Quirynen M. Antimicrobial capacity of leucocyte-and platelet rich fibrin against periodontal pathogens. Sci Rep. 2019;9(1):8188.
Kargarpour Z, Nasirzade J, Strauss FJ, et al. Platelet-rich fibrin suppresses in vitro osteoclastogenesis. J Periodontol. 2020;91(3):413-421.
Pitzurra L, Jansen IDC, de Vries TJ, Hoogenkamp MA, Loos BG. Effects of L-PRF and A-PRF+ on periodontal fibroblasts in in vitro wound healing experiments. J Periodontal Res. 2020;55(2):287-295.
Choukroun J, Diss A, Simonpieri A, et al. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part IV: clinical effects on tissue healing. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006a;101(3):e56-e60.
Choukroun J, Diss A, Simonpieri A, et al. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part V: histologic evaluations of PRF effects on bone allograft maturation in sinus lift. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006b;101(3):299-303.
Dohan DM, Choukroun J, Diss A, et al. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part I: technological concepts and evolution. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006a;101(3):e37-e44.
Dohan DM, Choukroun J, Diss A, et al. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part II: platelet-related biologic features. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006b;101(3):e45-e50.
Dohan DM, Choukroun J, Diss A, et al. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part III: leucocyte activation: a new feature for platelet concentrates? Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006c;101(3):e51-e55.
Andrade C, Camino J, Nally M, Quirynen M, Martínez B, Pinto N. Combining autologous particulate dentin, L-PRF, and fibrinogen to create a matrix for predictable ridge preservation: a pilot clinical study. Clin Oral Investig. 2020;24(3):1151-1160.
Oneto P, Zubiry PR, Schattner M, Etulain J. Anticoagulants interfere with the Angiogenic and regenerative responses mediated by platelets. Front Bioeng Biotechnol. 2020;8:223.
Castro AB, Cortellini S, Temmerman A, et al. Characterization of the leukocyte- and platelet-rich fibrin block: release of growth factors, cellular content, and structure. Int J Oral Maxillofac Implants. 2019;34(4):855-864.
Upadhayayaa V, Arorab A, Goyal A. Bioactive platelet aggregates: Prp, Prgf, Prf, Cgf and sticky bone. IOSR J Dent Med Sci. 2017;16(5):5-11.
Kobayashi E, Flückiger L, Fujioka-Kobayashi M, et al. Comparative release of growth factors from PRP, PRF, and advanced-PRF. Clin Oral Investig. 2016;20(9):2353-2360.
Anitua E, Zalduendo MM, Alkhraisat MH, Orive G. Release kinetics of platelet-derived and plasma-derived growth factors from autologous plasma rich in growth factors. Ann Anat. 2013;195(5):461-466.
Miron RJ, Choukroun J. Platelet Rich Fibrin in Regenerative Dentistry: Biological Background and Clinical Indications. John Wiley & Sons; 2017.
Bai MY, Wang CW, Wang JY, Lin MF, Chan WP. Three-dimensional structure and cytokine distribution of platelet-rich fibrin. Clinics (Sao Paulo). 2017;72(2):116-124.
Rodella LF, Favero G, Boninsegna R, et al. Growth factors, CD34 positive cells, and fibrin network analysis in concentrated growth factors fraction. Microsc Res Tech. 2011;74(8):772-777.
Lee HM, Shen EC, Shen JT, Fu E, Chiu HC, Hsia YJ. Tensile strength, growth factor content and proliferation activities for two platelet concentrates of platelet-rich fibrin and concentrated growth factor. J Dent Sci. 2020;15(2):141-146.
Fujioka-Kobayashi M, Miron RJ, Hernandez M, Kandalam U, Zhang Y, Choukroun J. Optimized platelet-rich fibrin with the low-speed concept: growth factor release, biocompatibility, and cellular response. J Periodontol. 2017;88(1):112-121.
Tunalı M, Özdemir H, Küçükodacı Z, et al. A novel platelet concentrate: titanium-prepared platelet-rich fibrin. Biomed Res Int. 2014;2014:209548.
Miron RJ, Chai J, Zheng S, Feng M, Sculean A, Zhang Y. A novel method for evaluating and quantifying cell types in platelet rich fibrin and an introduction to horizontal centrifugation. J Biomed Mater Res A. 2019;107(10):2257-2271.
Ghanaati S, Booms P, Orlowska A, et al. Advanced platelet-rich fibrin: a new concept for cell-based tissue engineering by means of inflammatory cells. J Oral Implantol. 2014;40(6):679-689.
Varela HA, Souza JCM, Nascimento RM, et al. Injectable platelet rich fibrin: cell content, morphological, and protein characterization. Clin Oral Investig. 2019;23(3):1309-1318.
Cortellini S, Castro AB, Temmerman A, et al. Leucocyte- and platelet-rich fibrin block for bone augmentation procedure: a proof-of-concept study. J Clin Periodontol. 2018;45(5):624-634.
Miron RJ, Chai J, Zhang P, et al. A novel method for harvesting concentrated platelet-rich fibrin (C-PRF) with a 10-fold increase in platelet and leukocyte yields. Clin Oral Investig. 2020;24(8):2819-2828.
Pinto N, Quirynen M. Letter to the editor: RE: optimized platelet-rich fibrin with the low-speed concept: growth factor release, biocompatibility, and cellular response. J Periodontol. 2019;90(2):119-121.
Miron RJ, Pinto NR, Quirynen M, Ghanaati S. Standardization of relative centrifugal forces in studies related to platelet-rich fibrin. J Periodontol. 2019b;90(8):817-820.
Woodman R, Ferrucci L, Guralnik J. Anemia in older adults. Curr Opin Hematol. 2005;12(2):123-128.
Zeng SM, Yankowitz J, Widness JA, Strauss RG. Etiology of differences in hematocrit between males and females: sequence-based polymorphisms in erythropoietin and its receptor. J Gend Specif Med. 2001;4(1):35-40.
Miron RJ, Dham A, Dham U, Zhang Y, Pikos MA, Sculean A. The effect of age, gender, and time between blood draw and start of centrifugation on the size outcomes of platelet-rich fibrin (PRF) membranes. Clin Oral Investig. 2019;23(5):2179-2185.
Yajamanya SR, Chatterjee A, Babu CN, Karunanithi D. Fibrin network pattern changes of platelet-rich fibrin in young versus old age group of individuals: a cell block cytology study. J Indian Soc Periodontol. 2016;20(2):151-156.
Mishra A, Randelli P, Barr C, Talamonti T, Ragone V, Cabitza P. Platelet-rich plasma and the upper extremity. Hand Clin. 2012;28(4):481-491.
Bielecki T, Dohan Ehrenfest DM, Everts PA, Wiczkowski A. The role of leukocytes from L-PRP/L-PRF in wound healing and immune defense: new perspectives. Curr Pharm Biotechnol. 2012;13(7):1153-1162.
Moojen DJ, Everts PA, Schure RM, et al. Antimicrobial activity of platelet-leukocyte gel against Staphylococcus aureus. J Orthop Res. 2008;26(3):404-410.
Martin P, Leibovich SJ. Inflammatory cells during wound repair: the good, the bad and the ugly. Trends Cell Biol. 2005;15(11):599-607.
Tsirogianni AK, Moutsopoulos NM, Moutsopoulos HM. Wound healing: immunological aspects. Injury. 2006;37(Suppl 1):S5-S12.
Barrick B, Campbell EJ, Owen CA. Leukocyte proteinases in wound healing: roles in physiologic and pathologic processes. Wound Repair Regen. 1999;7(6):410-422.
Lingen MW. Role of leukocytes and endothelial cells in the development of angiogenesis in inflammation and wound healing. Arch Pathol Lab Med. 2001;125(1):67-71.
Adamson R. Role of macrophages in normal wound healing: an overview. J Wound Care. 2009;18(8):349-351.
Eming SA, Hammerschmidt M, Krieg T, Roers A. Interrelation of immunity and tissue repair or regeneration. Semin Cell Dev Biol. 2009;20(5):517-527.
Schultz GS, Wysocki A. Interactions between extracellular matrix and growth factors in wound healing. Wound Repair Regen. 2009;17(2):153-162.
Barrientos S, Stojadinovic O, Golinko MS, Brem H, Tomic-Canic M. Growth factors and cytokines in wound healing. Wound Repair Regen. 2008;16(5):585-601.
Cieslik-Bielecka A, Dohan Ehrenfest DM, Lubkowska A, Bielecki T. Microbicidal properties of leukocyte- and platelet-rich plasma/fibrin (L-PRP/L-PRF): new perspectives. J Biol Regul Homeost Agents. 2012;26(2 Suppl 1):43S-52S.
Nasirzade J, Kargarpour Z, Hasannia S, Strauss FJ, Gruber R. Platelet-rich fibrin elicits an anti-inflammatory response in macrophages in vitro. J Periodontol. 2020;91(2):244-252.
Toffler M, Toscano N, Holtzclaw D. Osteotome-mediated sinus floor elevation using only platelet-rich fibrin: an early report on 110 patients. Implant Dent. 2010;19(5):447-456.
Tan WL, Wong TL, Wong MC, Lang NP. A systematic review of post-extractional alveolar hard and soft tissue dimensional changes in humans. Clin Oral Implants Res. 2012;23(Suppl 5):1-21.
Couso-Queiruga E, Stuhr S, Tattan M, Chambrone L, Avila-Ortiz G. Post-extraction dimensional changes: a systematic review and meta-analysis. J Clin Periodontol. 2021;48(1):126-144.
García-González S, Galve-Huertas A, Aboul-Hosn Centenero S, Mareque-Bueno S, Satorres-Nieto M, Hernández-Alfaro F. Volumetric changes in alveolar ridge preservation with a compromised buccal wall: a systematic review and meta-analysis. Med Oral Patol Oral Cir Bucal. 2020;25(5):e565-e575.
Barootchi S, Wang HL, Ravida A, et al. Ridge preservation techniques to avoid invasive bone reconstruction: a systematic review and meta-analysis: Naples consensus report working group C. Int J Oral Implantol (Berl). 2019;12(4):399-416.
Troiano G, Zhurakivska K, Lo Muzio L, Laino L, Cicciù M, Lo Russo L. Combination of bone graft and resorbable membrane for alveolar ridge preservation: a systematic review, meta-analysis, and trial sequential analysis. J Periodontol. 2018;89(1):46-57.
Vignoletti F, Matesanz P, Rodrigo D, Figuero E, Martin C, Sanz M. Surgical protocols for ridge preservation after tooth extraction. A systematic review. Clin Oral Implants Res. 2012;23(Suppl 5):22-38.
Dragonas P, Katsaros T, Avila-Ortiz G, Chambrone L, Schiavo JH, Palaiologou A. Effects of leukocyte-platelet-rich fibrin (L-PRF) in different intraoral bone grafting procedures: a systematic review. Int J Oral Maxillofac Surg. 2019;48(2):250-262.
Dragonas P, Schiavo JH, Avila-Ortiz G, Palaiologou A, Katsaros T. Plasma rich in growth factors (PRGF) in intraoral bone grafting procedures: a systematic review. J Craniomaxillofac Surg. 2019;47(3):443-453.
Temmerman A, Vandessel J, Castro A, et al. The use of leucocyte and platelet-rich fibrin in socket management and ridge preservation: a split-mouth, randomized, controlled clinical trial. J Clin Periodontol. 2016;43(11):990-999.
Alissa R, Esposito M, Horner K, Oliver R. The influence of platelet-rich plasma on the healing of extraction sockets: an explorative randomised clinical trial. Eur J Oral Implantol. 2010;3(2):121-134.
Nisar N, Nilesh K, Parkar MI, Punde P. Extraction socket preservation using a collagen plug combined with platelet-rich plasma (PRP): a comparative clinico-radiographic study. J Dent Res Dent Clin Dent Prospects. 2020;14(2):139-145.
Farina R, Bressan E, Taut A, Cucchi A, Trombelli L. Plasma rich in growth factors in human extraction sockets: a radiographic and histomorphometric study on early bone deposition. Clin Oral Implants Res. 2013;24(12):1360-1368.
Anitua E, Murias-Freijo A, Alkhraisat MH, Orive G. Clinical, radiographical, and histological outcomes of plasma rich in growth factors in extraction socket: a randomized controlled clinical trial. Clin Oral Investig. 2015;19(3):589-600.
Cocero N, Caratori E, Martini S, Carossa S. Can plasma rich in growth factors expedite healing of Postextraction tooth sockets in patients undergoing urgent liver transplantation? J Oral Maxillofac Surg. 2021;79(2):305-312.
Mozzati M, Gallesio G, di Romana S, Bergamasco L, Pol R. Efficacy of plasma-rich growth factor in the healing of postextraction sockets in patients affected by insulin-dependent diabetes mellitus. J Oral Maxillofac Surg. 2014;72(3):456-462.
Stumbras A, Januzis G, Gervickas A, Kubilius R, Juodzbalys G. Randomized and controlled clinical trial of bone healing after alveolar ridge preservation using xenografts and allografts versus plasma rich in growth factors. J Oral Implantol. 2020;46(5):515-525.
Alzahrani AA, Murriky A, Shafik S. Influence of platelet rich fibrin on post- extraction socket healing: a clinical and radiographic study. Saudi Dent J. 2017;29(4):149-155.
Zhang Y, Ruan Z, Shen M, et al. Clinical effect of platelet-rich fibrin on the preservation of the alveolar ridge following tooth extraction. Exp Ther Med. 2018;15(3):2277-2286.
Canellas JVDS, da Costa RC, Breves RC, et al. Tomographic and histomorphometric evaluation of socket healing after tooth extraction using leukocyte- and platelet-rich fibrin: a randomized, single-blind, controlled clinical trial. J Craniomaxillofac Surg. 2020;48(1):24-32.
Ma F, Lin Y, Sun F, Jiang X, Wei T. The impact of autologous concentrated growth factors on the alveolar ridge preservation after posterior tooth extraction: a prospective, randomized controlled clinical trial. Clin Implant Dent Relat Res. 2021;23(4):579-592.
Hauser F, Gaydarov N, Badoud I, Vazquez L, Bernard JP, Ammann P. Clinical and histological evaluation of postextraction platelet-rich fibrin socket filling: a prospective randomized controlled study. Implant Dent. 2013;22(3):295-303.
Marenzi G, Riccitiello F, Tia M, di Lauro A, Sammartino G. Influence of leukocyte- and platelet-rich fibrin (L-PRF) in the healing of simple Postextraction sockets: a Split-mouth study. Biomed Res Int. 2015;2015:369273.
de Almeida Barros Mourão CF, Calasans-Maia MD, de Mello Machado RC, de Brito Resende RF, Alves GG. The use of platelet-rich fibrin as a hemostatic material in oral soft tissues. Oral Maxillofac Surg. 2018;22(3):329-333.
Liu YH, To M, Okudera T, et al. Advanced platelet-rich fibrin (A-PRF) has an impact on the initial healing of gingival regeneration after tooth extraction. J Oral Biosci. 2022;64(1):141-147.
Suttapreyasri S, Leepong N. Influence of platelet-rich fibrin on alveolar ridge preservation. J Craniofac Surg. 2013;24(4):1088-1094.
Girish Kumar N, Chaudhary R, Kumar I, Arora SS, Kumar N, Singh H. To assess the efficacy of socket plug technique using platelet rich fibrin with or without the use of bone substitute in alveolar ridge preservation: a prospective randomised controlled study. Oral Maxillofac Surg. 2018;22(2):135-142.
Srinivas B, Das P, Rana MM, Qureshi AQ, Vaidya KC, Ahmed Raziuddin SJ. Wound healing and bone regeneration in Postextraction sockets with and without platelet-rich fibrin. Ann Maxillofac Surg. 2018;8(1):28-34.
Areewong K, Chantaramungkorn M, Khongkhunthian P. Platelet-rich fibrin to preserve alveolar bone sockets following tooth extraction: a randomized controlled trial. Clin Implant Dent Relat Res. 2019;21(6):1156-1163.
Lundgren S, Andersson S, Sennerby L. Spontaneous bone formation in the maxillary sinus after removal of a cyst: coincidence or consequence? Clin Implant Dent Relat Res. 2003;5(2):78-81.
Thor A, Sennerby L, Hirsch JM, Rasmusson L. Bone formation at the maxillary sinus floor following simultaneous elevation of the mucosal lining and implant installation without graft material: an evaluation of 20 patients treated with 44 Astra tech implants. J Oral Maxillofac Surg. 2007;65(7 Suppl 1):64-72.
Si MS, Shou YW, Shi YT, Yang GL, Wang HM, He FM. Long-term outcomes of osteotome sinus floor elevation without bone grafts: a clinical retrospective study of 4-9 years. Clin Oral Implants Res. 2016;27(11):1392-1400.
Borges FL, Dias RO, Piattelli A, et al. Simultaneous sinus membrane elevation and dental implant placement without bone graft: a 6-month follow-up study. J Periodontol. 2011;82(3):403-412.
Nedir R, Nurdin N, Khoury P, et al. Osteotome sinus floor elevation with and without grafting material in the severely atrophic maxilla. A 1-year prospective randomized controlled study. Clin Oral Implants Res. 2013;24(11):1257-1264.
Nedir R, Nurdin N, Abi Najm S, El Hage M, Bischof M. Short implants placed with or without grafting into atrophic sinuses: the 5-year results of a prospective randomized controlled study. Clin Oral Implants Res. 2017;28(7):877-886.
Nedir R, Nurdin N, Khoury P, Bischof M. Short implants placed with or without grafting in atrophic sinuses: the 3-year results of a prospective randomized controlled study. Clin Implant Dent Relat Res. 2016;18(1):10-18.
Duan DH, Fu JH, Qi W, Du Y, Pan J, Wang HL. Graft-free maxillary sinus floor elevation: a systematic review and meta-analysis. J Periodontol. 2017;88(6):550-564.
Anitua E, Flores J, Alkhraisat MH. Transcrestal sinus lift using platelet concentrates in association to short implant placement: a retrospective study of augmented bone height remodeling. Clin Implant Dent Relat Res. 2016;18(5):993-1002.
Diss A, Dohan DM, Mouhyi J, Mahler P. Osteotome sinus floor elevation using Choukroun's platelet-rich fibrin as grafting material: a 1-year prospective pilot study with microthreaded implants. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008;105(5):572-579.
Kanayama T, Horii K, Senga Y, Shibuya Y. Crestal approach to sinus floor elevation for atrophic maxilla using platelet-rich fibrin as the only grafting material: a 1-year prospective study. Implant Dent. 2016;25(1):32-38.
Molemans B, Cortellini S, Jacobs R, Pinto N, Teughels W, Quirynen M. Simultaneous sinus floor elevation and implant placement using leukocyte- and platelet-rich fibrin as a sole graft material. Int J Oral Maxillofac Implants. 2019;34(5):1195-1201.
Testori T, Panda S, Clauser T, et al. Short implants and platelet-rich fibrin for transcrestal sinus floor elevation: a prospective multicenter clinical study. J Biol Regul Homeost Agents. 2019;33(6 Suppl. 2):121-135.
Kim JM, Sohn DS, Bae MS, Moon JW, Lee JH, Park IS. Flapless transcrestal sinus augmentation using hydrodynamic piezoelectric internal sinus elevation with autologous concentrated growth factors alone. Implant Dent. 2014;23(2):168-174.
Chen Y, Cai Z, Zheng D, et al. Inlay osteotome sinus floor elevation with concentrated growth factor application and simultaneous short implant placement in severely atrophic maxilla. Sci Rep. 2016;6:27348.
Cho YS, Hwang KG, Jun SH, Tallarico M, Kwon AM, Park CJ. Radiologic comparative analysis between saline and platelet-rich fibrin filling after hydraulic transcrestal sinus lifting without adjunctive bone graft: a randomized controlled trial. Clin Oral Implants Res. 2020;31(11):1087-1093.
Mazor Z, Horowitz RA, Del Corso M, Prasad HS, Rohrer MD, Dohan Ehrenfest DM. Sinus floor augmentation with simultaneous implant placement using Choukroun's platelet-rich fibrin as the sole grafting material: a radiologic and histologic study at 6 months. J Periodontol. 2009;80(12):2056-2064.
Simonpieri A, Choukroun J, Del Corso M, Sammartino G, Dohan Ehrenfest DM. Simultaneous sinus-lift and implantation using microthreaded implants and leukocyte- and platelet-rich fibrin as sole grafting material: a six-year experience. Implant Dent. 2011;20(1):2-12.
Tajima N, Ohba S, Sawase T, Asahina I. Evaluation of sinus floor augmentation with simultaneous implant placement using platelet-rich fibrin as sole grafting material. Int J Oral Maxillofac Implants. 2013;28(1):77-83.
Dominiak S, Karuga-Kuźniewska E, Popecki P, Kubasiewicz-Ross P. PRF versus xenograft in sinus augmentation in case of HA-coating implant placement: a 36-month retrospective study. Adv Clin Exp Med. 2021;30(6):633-640.
Merli M, Moscatelli M, Merli M, Mariotti G, Pagliaro U, Nieri M. Lateral sinus floor elevation in the severely atrophied maxilla: concentrated growth factors versus bone substitutes. A controlled clinical trial. Int J Periodontics Restorative Dent. 2022;42(1):65-72.
Cortellini P, Bowers GM. Periodontal regeneration of intrabony defects: an evidence-based treatment approach. Int J Periodontics Restorative Dent. 1995;15(2):128-145.
Palmer RM, Cortellini P, Group B of European Workshop on Periodontology. Periodontal tissue engineering and regeneration: consensus report of the sixth European workshop on periodontology. J Clin Periodontol. 2008;35(8 Suppl):83-86.
Cortellini P, Tonetti MS. Clinical concepts for regenerative therapy in intrabony defects. Periodontol 2000. 2015;68(1):282-307.
Reynolds MA, Kao RT, Camargo PM, et al. Periodontal regeneration - intrabony defects: a consensus report from the AAP regeneration workshop. J Periodontol. 2015;86(2 Suppl):S105-S107.
Kao RT, Nares S, Reynolds MA. Periodontal regeneration - intrabony defects: a systematic review from the AAP regeneration workshop. J Periodontol. 2015;86(2 Suppl):S77-S104.
Zhou S, Sun C, Huang S, et al. Efficacy of adjunctive bioactive materials in the treatment of periodontal intrabony defects: a systematic review and meta-analysis. Biomed Res Int. 2018;2018:8670832.
Miron RJ, Moraschini V, Fujioka-Kobayashi M, et al. Use of platelet-rich fibrin for the treatment of periodontal intrabony defects: a systematic review and meta-analysis. Clin Oral Investig. 2021;25(5):2461-2478.
Pradeep AR, Rao NS, Agarwal E, Bajaj P, Kumari M, Naik SB. Comparative evaluation of autologous platelet-rich fibrin and platelet-rich plasma in the treatment of 3-wall intrabony defects in chronic periodontitis: a randomized controlled clinical trial. J Periodontol. 2012;83(12):1499-1507.
Khalifehzadeh S, Haghanifar S, Jenabian N, Kazemi S, Hajiahmadi M. Clinical and radiographic evaluation of applying 1% metformin biofilm with plasma rich in growth factor (PRGF) for treatment of two-wall intrabony periodontal defects: a randomized clinical trial. J Dent Res Dent Clin Dent Prospects. 2019;13(1):51-56.
Arabaci T, Albayrak M. Titanium-prepared platelet-rich fibrin provides advantages on periodontal healing: a randomized split-mouth clinical study. J Periodontol. 2018;89(3):255-264.
Ustaoğlu G, Uğur Aydin Z, Özelçi F. Comparison of GTR, T-PRF and open-flap debridement in the treatment of intrabony defects with endo-perio lesions: a randomized controlled trial. Med Oral Patol Oral Cir Bucal. 2020;25(1):e117-e123.
Kizildağ A, Taşdemir U, Arabaci T, Özmen Ö, Kizildağ CA, Iyilikci B. Evaluation of new bone formation using autogenous tooth bone graft combined with platelet-rich fibrin in Calvarial defects. J Craniofac Surg. 2019;30(6):1662-1666.
Rosamma Joseph V, Raghunath A, Sharma N. Clinical effectiveness of autologous platelet rich fibrin in the management of infrabony periodontal defects. Singapore Dent J. 2012;33(1):5-12.
Pradeep AR, Garg V, Kanoriya D, Singhal S. Platelet-rich fibrin with 1.2% Rosuvastatin for treatment of Intrabony defects in chronic periodontitis: a randomized controlled clinical trial. J Periodontol. 2016;87(12):1468-1473.
Martande SS, Kumari M, Pradeep AR, Singh SP, Suke DK, Guruprasad CN. Platelet-rich fibrin combined with 1.2% atorvastatin for treatment of Intrabony defects in chronic periodontitis: a randomized controlled clinical trial. J Periodontol. 2016;87(9):1039-1046.
Chandradas ND, Ravindra S, Rangaraju VM, Jain S, Dasappa S. Efficacy of platelet rich fibrin in the treatment of human intrabony defects with or without bone graft: a randomized controlled trial. J Int Soc Prev Community Dent. 2016;6(Suppl 2):S153-S169.
Chatterjee A, Pradeep AR, Garg V, Yajamanya S, Ali MM, Priya VS. Treatment of periodontal intrabony defects using autologous platelet-rich fibrin and titanium platelet-rich fibrin: a randomized, clinical, comparative study. J Investig Clin Dent. 2017;8(3):e12231.
Patel GK, Gaekwad SS, Gujjari SK, Veerendra Kumar SC. Platelet-rich fibrin in regeneration of Intrabony defects: a randomized controlled trial. J Periodontol. 2017;88(11):1192-1199.
Yajamanya SR, Chatterjee A, Hussain A, Coutinho A, Das S, Subbaiah S. Bioactive glass versus autologous platelet-rich fibrin for treating periodontal intrabony defects: a comparative clinical study. J Indian Soc Periodontol. 2017;21(1):32-36.
Thorat M, Pradeep AR, Pallavi B. Clinical effect of autologous platelet-rich fibrin in the treatment of intra-bony defects: a controlled clinical trial. J Clin Periodontol. 2011;38(10):925-932.
Sharma A, Pradeep AR. Treatment of 3-wall intrabony defects in patients with chronic periodontitis with autologous platelet-rich fibrin: a randomized controlled clinical trial. J Periodontol. 2011a;82(12):1705-1712.
Ajwani H, Shetty S, Gopalakrishnan D, et al. Comparative evaluation of platelet-rich fibrin biomaterial and open flap debridement in the treatment of two and three wall intrabony defects. J Int Oral Health. 2015;7(4):32-37.
Pradeep AR, Nagpal K, Karvekar S, Patnaik K, Naik SB, Guruprasad CN. Platelet-rich fibrin with 1% metformin for the treatment of intrabony defects in chronic periodontitis: a randomized controlled clinical trial. J Periodontol. 2015;86(6):729-737.
Bajaj P, Pradeep AR, Agarwal E, et al. Comparative evaluation of autologous platelet-rich fibrin and platelet-rich plasma in the treatment of mandibular degree II furcation defects: a randomized controlled clinical trial. J Periodontal Res. 2013;48(5):573-581.
Kanoriya D, Pradeep AR, Singhal S, Garg V, Guruprasad CN. Synergistic approach using platelet-rich fibrin and 1% alendronate for Intrabony defect treatment in chronic periodontitis: a randomized clinical trial. J Periodontol. 2016;87(12):1427-1435.
Pradeep AR, Bajaj P, Rao NS, Agarwal E, Naik SB. Platelet-rich fibrin combined with a porous hydroxyapatite graft for the treatment of 3-wall Intrabony defects in chronic periodontitis: a randomized controlled clinical trial. J Periodontol. 2017;88(12):1288-1296.
Thorat M, Baghele ON, Rakhewar PS. Adjunctive effect of autologous platelet-rich fibrin in the treatment of intrabony defects in localized aggressive periodontitis patients: a randomized controlled Split-mouth clinical trial. Int J Periodontics Restorative Dent. 2017;37(6):e302-e309.
Pham TAV. Intrabony defect treatment with platelet-rich fibrin, guided tissue regeneration and open-flap debridement: a randomized controlled trial. J Evid Based Dent Pract. 2021;21(3):101545.
Suchetha A, Lakshmi P, Bhat D, Mundinamane DB, Soorya KV, Bharwani GA. Platelet concentration in platelet concentrates and periodontal regeneration-unscrambling the ambiguity. Contemp Clin Dent. 2015;6(4):510-516.
Hanna R, Trejo PM, Weltman RL. Treatment of intrabony defects with bovine-derived xenograft alone and in combination with platelet-rich plasma: a randomized clinical trial. J Periodontol. 2004;75(12):1668-1677.
Ouyang XY, Qiao J. Effect of platelet-rich plasma in the treatment of periodontal intrabony defects in humans. Chin Med J (Engl). 2006;119(18):1511-1521.
Döri F, Kovács V, Arweiler NB, et al. Effect of platelet-rich plasma on the healing of intrabony defects treated with an anorganic bovine bone mineral: a pilot study. J Periodontol. 2009;80(10):1599-1605.
Sezgin Y, Uraz A, Taner IL, Çulhaoğlu R. Effects of platelet-rich fibrin on healing of intra-bony defects treated with anorganic bovine bone mineral. Braz Oral Res. 2017;31:e15.
Goyal J, Sachdeva S, Salaria SK, Vakil N, Mittal A. Comparative assessment of periodontal regeneration in periodontal intraosseous defects treated with PepGen P-15 unaided or in blend with platelet-rich fibrin: a clinical and high- resolution computed tomography scan-assisted volumetric analysis. J Indian Soc Periodontol. 2020;24(2):156-162.
Qiao J, Duan J, Zhang Y, Chu Y, Sun C. The effect of concentrated growth factors in the treatment of periodontal intrabony defects. Future Sci OA. 2016;2(4):FS136.
Xu Y, Qiu J, Sun Q, et al. One-year results evaluating the effects of concentrated growth factors on the healing of intrabony defects treated with or without bone substitute in chronic periodontitis. Med Sci Monit. 2019;25:4384-4389.
Del Fabbro M, Bortolin M, Taschieri S. Is autologous platelet concentrate beneficial for post-extraction socket healing? A systematic review. Int J Oral Maxillofac Surg. 2011;40(9):891-900. doi:10.1016/j.ijom.2011.04.009
Anwandter A, Bohmann S, Nally M, Castro AB, Quirynen M, Pinto N. Dimensional changes of the post extraction alveolar ridge, preserved with leukocyte- and platelet rich fibrin: a clinical pilot study. J Dent. 2016;52:23-29.
Chen H, Zhou L, Wu D, Zhang J, Zheng Y, Chen Y. Osteotome sinus floor elevation with concentrated growth factor and simultaneous implant placement with or without bone grafting: a retrospective study. Int J Oral Maxillofac Surg. 2022;51(8):1078-1084.