Effect of Host Cholesterol on the Membrane Dynamics of Outer Membrane Lipids of Mycobacteria.
Cholesterol
Latent Tubercular infection
Membrane order
Membrane-drug interactions
Mycobacterial membrane lipids
Phase-segregated lipid domains
Journal
Chemistry, an Asian journal
ISSN: 1861-471X
Titre abrégé: Chem Asian J
Pays: Germany
ID NLM: 101294643
Informations de publication
Date de publication:
01 Dec 2023
01 Dec 2023
Historique:
revised:
16
10
2023
received:
09
08
2023
medline:
4
12
2023
pubmed:
17
10
2023
entrez:
17
10
2023
Statut:
ppublish
Résumé
The ability of Mycobacterium tuberculosis to remain dormant after primary infection represents the prime cause of new TB cases throughout the world. Hence, diagnosis and treatment of individuals hosting dormant mycobacterium is one of the crucial strategies to be adopted for the prevention of Tuberculosis. Among many strategies unleashed by the latent bacterium, one of them is scavenging host cholesterol for carbon source. Cholesterol modifies lipid membranes over many scales and here, its effect on mycobacterial membrane biophysics and the subsequent effect on partitioning of antibiotics into cholesterol- enriched mycobacterial membranes was investigated. Our research showed that cholesterol alters the phase state behavior of mycobacterial outer membrane lipids by enhancing the overall membrane order at the headgroup and acyl chain region and is integrated into both ordered and disordered domains/phases, with a preference for the latter. Exogenous cholesterol further alters the drug partitioning behavior of structurally different drugs, pointing to a larger clinical potential of using more hydrophobic medications to target dormant bacteria.
Identifiants
pubmed: 37846643
doi: 10.1002/asia.202300697
doi:
Substances chimiques
Membrane Lipids
0
Cholesterol
97C5T2UQ7J
Lipid Bilayers
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e202300697Subventions
Organisme : DBT (Department of Biotechnology, Government of India
Organisme : IRCC (IIT Bombay
Informations de copyright
© 2023 Wiley-VCH GmbH.
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