Neurocognitive skills and vulnerability for psychosis in depression and across the psychotic spectrum: findings from the PRONIA Consortium.

Humans Depression / epidemiology Neuropsychological Tests Psychotic Disorders / psychology Cognition Disorders Cognitive Dysfunction / epidemiology
Cognitive neuroscience clinical high risk recent-onset depression recent-onset psychosis risk assessment

Journal

The British journal of psychiatry : the journal of mental science
ISSN: 1472-1465
Titre abrégé: Br J Psychiatry
Pays: England
ID NLM: 0342367

Informations de publication

Date de publication:
10 2023
Historique:
medline: 23 10 2023
pubmed: 17 10 2023
entrez: 17 10 2023
Statut: ppublish

Résumé

Neurocognitive deficits are a core feature of psychosis and depression. Despite commonalities in cognitive alterations, it remains unclear if and how the cognitive deficits in patients at clinical high risk for psychosis (CHR) and those with recent-onset psychosis (ROP) are distinct from those seen in recent-onset depression (ROD). This study was carried out within the European project 'Personalized Prognostic Tools for Early Psychosis Management', and aimed to characterise the cognitive profiles of patients with psychosis or depression. We examined cognitive profiles for patients with ROP ( Patients with ROP performed worse than healthy controls in all four domains ( These results show that neurocognitive abilities are affected in CHR and ROP, whereas ROD seems spared. Although our findings may support the notion that those at CHR have a specific vulnerability to psychosis, future studies investigating broader transdiagnostic risk cohorts in longitudinal designs are needed.

Sections du résumé

BACKGROUND
Neurocognitive deficits are a core feature of psychosis and depression. Despite commonalities in cognitive alterations, it remains unclear if and how the cognitive deficits in patients at clinical high risk for psychosis (CHR) and those with recent-onset psychosis (ROP) are distinct from those seen in recent-onset depression (ROD).
AIMS
This study was carried out within the European project 'Personalized Prognostic Tools for Early Psychosis Management', and aimed to characterise the cognitive profiles of patients with psychosis or depression.
METHOD
We examined cognitive profiles for patients with ROP (
RESULTS
Patients with ROP performed worse than healthy controls in all four domains (
CONCLUSIONS
These results show that neurocognitive abilities are affected in CHR and ROP, whereas ROD seems spared. Although our findings may support the notion that those at CHR have a specific vulnerability to psychosis, future studies investigating broader transdiagnostic risk cohorts in longitudinal designs are needed.

Identifiants

DOI: 10.1192/bjp.2023.98 PMID: 37846967
pubmed: 37846967
doi: 10.1192/bjp.2023.98
pii: S0007125023000983
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

485-492

Auteurs

Carolina Bonivento (C)

Scientific Institute, IRCCS E. Medea, Pasian di Prato, Udine, Italy.
ORCID: 0000-0003-3354-7494

Lana Kambeitz-Ilankovic (L)

Faculty of Medicine and University Hospital of Cologne, University of Cologne, Germany; and Faculty of Psychology and Educational Sciences, Department of Psychology, Ludwig-Maximilian University, Germany.
ORCID: 0000-0002-8218-0425

Eleonora Maggioni (E)

Department of Electronics, Information and Bioengineering, Politecnico di Milano, Italy.

Stefan Borgwardt (S)

Translational Psychiatry Unit, Department of Psychiatry and Psychotherapy, University of Lübeck, Germany.

Rebekka Lencer (R)

Institute for Translational Psychiatry, Münster University, Germany.

Eva Meisenzahl (E)

Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich-Heine University, Germany.

Joseph Kambeitz (J)

Faculty of Medicine and University Hospital of Cologne, University of Cologne, Germany; and Cognitive Neuroscience (INM-3), Institute of Neuroscience and Medicine, Research Center Jülich, Germany.
ORCID: 0000-0002-8988-3959

Stephan Ruhrmann (S)

Faculty of Medicine and University Hospital of Cologne, University of Cologne, Germany.

Raimo K R Salokangas (RKR)

Department of Psychiatry, University of Turku, Finland.

Alessandro Bertolino (A)

Department of Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari Aldo Moro, Italy.

Alexandra Stainton (A)

Orygen, Melbourne, Australia; and Centre for Youth Mental Health, University of Melbourne, Australia.

Julian Wenzel (J)

Faculty of Medicine and University Hospital of Cologne, University of Cologne, Germany.

Christos Pantelis (C)

Melbourne Neuropsychiatry Centre, University of Melbourne and Melbourne Health, Australia.

Stephen J Wood (SJ)

Orygen, Melbourne, Australia; School of Psychology, University of Birmingham, UK; and Centre for Youth Mental Health, University of Melbourne, Australia.

Rachel Upthegrove (R)

School of Psychology, University of Birmingham, UK; Institute for Mental Health, University of Birmingham, UK; and Centre for Human Brain Health, University of Birmingham, UK.

Nikolaos Koutsouleris (N)

Department of Psychiatry and Psychotherapy, Ludwig-Maximilian University, Germany; Max Planck Institute for Psychiatry, Germany; and Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK.
ORCID: 0000-0001-6825-6262

Paolo Brambilla (P)

Department of Neurosciences and Mental Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Italy; and Department of Pathophysiology and Transplantation, University of Milan, Italy.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Neurocognitive skills and vulnerability for...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Émotions › Dépression › Neurocognitive skills and vulnerability for...
questionsmedicales.fr › Disciplines et activités comportementales › Tests psychologiques › Tests neuropsychologiques › Neurocognitive skills and vulnerability for...
questionsmedicales.fr › Troubles mentaux › Schizophrénie et troubles avec traits psychotiques › Troubles psychotiques › Neurocognitive skills and vulnerability for...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Troubles de la cognition › Neurocognitive skills and vulnerability for...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Troubles de la cognition › Dysfonctionnement cognitif › Neurocognitive skills and vulnerability for...